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中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (03) : 364 -366. doi: 10.3877/cma.j.issn.1674-6902.2023.03.015

临床研究

AECOPD伴肺部感染吸入三联疗效与EOS相关性分析
张晓娟, 邓祥瑞, 陈睿, 钟文()   
  1. 610000 成都,成都市第三人民医院全科医学科
  • 收稿日期:2022-10-19 出版日期:2023-06-25
  • 通信作者: 钟文

Correlation analysis of inhalation triple efficacy and EOS of AECOPD with a pulmonary infection

Xiaojuan Zhang, Xiangrui Deng, Rui Chen   

  • Received:2022-10-19 Published:2023-06-25
引用本文:

张晓娟, 邓祥瑞, 陈睿, 钟文. AECOPD伴肺部感染吸入三联疗效与EOS相关性分析[J/OL]. 中华肺部疾病杂志(电子版), 2023, 16(03): 364-366.

Xiaojuan Zhang, Xiangrui Deng, Rui Chen. Correlation analysis of inhalation triple efficacy and EOS of AECOPD with a pulmonary infection[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(03): 364-366.

目的

分析慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease, AECOPD)伴肺部感染吸入三联疗效与嗜酸性粒细胞的相关性。

方法

选择2020年1月至2021年3月我院收治的三联吸入治疗AECOPD伴肺部感染患者69例为对象,将外周血EOS≥0.15×109/L 37例为观察组,外周血EOS<0.15×109/L 32例为对照组;记录两组恶化发生率及时间,采用Cox比例风险模型分析血清EOS与AECOPD伴肺部感染患者吸入三联治疗效果的关系。

结果

AECOPD伴肺部感染患者三联吸入治疗后恶化率为33.33%(23/69),其中观察组恶化率24.32%(9/37),对照组恶化率50.00%(16/32)。Kaplan-Meier分析显示观察组恶化发生风险低于对照组(Log Rank χ2=8.093,P=0.004);观察组首次出现恶化时间长于对照组(Log Rank χ2=5.854,P=0.014)。Cox回归分析显示外周血EOS水平<0.15×109/L是AECOPD伴肺部感染患者吸入三联治疗恶化风险因子(HR:1.614,95%CI:1.452~1.827),P<0.05。

结论

外周血EOS是恶化的风险因子,作为AECOPD伴肺部感染患者吸入三联治疗后恶化预测的生物标志物。

表1 两组临床资料对比
表2 EOS水平与患者吸入三联治疗效果Cox回归分析
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