切换至 "中华医学电子期刊资源库"

中华肺部疾病杂志(电子版) ›› 2021, Vol. 14 ›› Issue (01) : 111 -113. doi: 10.3877/cma.j.issn.1674-6902.2021.01.027

综述

外泌体m6A修饰的环状RNA调节低氧性肺动脉高压的研究
夏世金1, 徐康乔1, 周长喜2,(), 周敏3   
  1. 1. 200040 上海,复旦大学附属华东医院上海市老年医学研究所
    2. 100853 北京,解放军总医院第二医学中心老年医学科
    3. 201599 上海,上海市第六人民医院金山分院呼吸科
  • 收稿日期:2020-12-08 出版日期:2021-02-25
  • 通信作者: 周长喜
  • 基金资助:
    国家自然科学基金面上项目(81870044)

Research progress of the regulation of the circRNAs modified by exosomes M6A in hypoxic pulmonary hypertension

Shijin Xia1, Kangqiao Xu1, Changxi Zhou2()   

  • Received:2020-12-08 Published:2021-02-25
  • Corresponding author: Changxi Zhou
引用本文:

夏世金, 徐康乔, 周长喜, 周敏. 外泌体m6A修饰的环状RNA调节低氧性肺动脉高压的研究[J]. 中华肺部疾病杂志(电子版), 2021, 14(01): 111-113.

Shijin Xia, Kangqiao Xu, Changxi Zhou. Research progress of the regulation of the circRNAs modified by exosomes M6A in hypoxic pulmonary hypertension[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2021, 14(01): 111-113.

图1 circBMPR2调节HPH机制假设图
1
Prabhakar NR. 2019 nobel prize in physiology or medicine[J]. Physiology (Bethesda), 2020, 35(2): 81-83.
2
Mclaughlin VV, Archer SL, Badesch DB, et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association[J]. J Am Coll Cardiol, 2009, 53(17): 1573-1619.
3
Humbert M, Yaici A, De Groote P, et al. Screening for pulmonary arterial hypertension in patients with systemic sclerosis: clinical characteristics at diagnosis and long-term survival[J]. Arthritis Rheum, 2011, 63(11): 3522-3530.
4
Szabo L, Salzman J. Detecting circular RNAs: bioinformatic and experimental challenges[J]. Nat Rev Genet, 2016, 17(11): 679-692.
5
Liu L, Wang J, Khanabdali R, et al. Circular RNAs: Isolation, characterization and their potential role in diseases[J]. RNA Biol, 2017, 14(12): 1715-1721.
6
王翰宇,双晓萍,夏世金. 环状RNA和微小RNA在肺动脉高压发生中的作用与机制[J]. 老年医学与保健,2019, 25(6): 868-871.
7
Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges[J]. Nature, 2013, 495(7441): 384-388.
8
Memczak S, Jens M, Elefsinioti A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency[J]. Nature, 2013, 495(7441): 333-338.
9
Wang J, Zhu M, Pan J, et al. Circular RNAs: a rising star in respiratory diseases[J]. Respir Res, 2019, 20(1): 3.
10
王 坚,黄嘉楠,宋元林,等. 环状RNA的研究新进展[J]. 生命科学,2017, 29(11): 1141-1148.
11
徐康乔,夏世金,王 坚,等. 环状RNA与呼吸系统疾病[J]. 中国呼吸与危重监护杂志,2020, 19(6): 611-616.
12
Wang J, Zhu MC, Kalionis B, et al. Characteristics of circular RNA expression in lung tissues from mice with hypoxia induced pulmonary hypertension[J]. Int J Molecular Med, 2018, 42(3): 1353-1366.
13
夏世金,邰先桃,李 炳,等. 低氧性肺动脉高压小鼠肺的环状RNA表达谱研究[J/CD]. 中华肺部疾病杂志(电子版), 2015, 8(1): 40-44.
14
王 坚,胡明冬,唐晓丹,等. 慢病毒介导环状RNA mmu-circ-0001033过表达抑制低氧性小鼠肺动脉平滑肌细胞增殖的实验研究[J/CD]. 中华肺部疾病杂志(电子版), 2018, 11(1): 39-43.
15
Yang L, Liang H, Meng X, et al. mmu_circ_0000790 Is Involved in pulmonary vascular remodeling in mice with HPH via microRNA-374c-mediated FOXC1[J]. Mol Ther Nucleic Acids, 2020, 20: 292-307.
16
Mao Y, Wang Y, Dong L, et al. Hypoxic exosomes facilitate angiogenesis and metastasis in esophageal squamous cell carcinoma through altering the phenotype and transcriptome of endothelial cells[J]. J Exp Clin Cancer Res, 2019, 38(1): 389.
17
Zulueta A, Colombo M, Peli V, et al. Lung mesenchymal stem cells-derived extracellular vesicles attenuate the inflammatory profile of cystic fibrosis epithelial cells[J]. Cell Signal, 2018, 51: 110-118.
18
Zhao L, Luo H, Li X, et al. Exosomes derived from human pulmonary artery endothelial cells shift the balance between proliferation and apoptosis of smooth muscle cells[J]. Cardiology, 2017, 137(1): 43-53.
19
Aliotta JM, Pereira M, Wen S, et al. Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice[J]. Cardiovasc Res, 2016, 110(3): 319-330.
20
朱梦婵,邰先桃,王 坚,等. 外泌体及外泌体微小RNA在肺动脉高压中的作用与机制[J/CD]. 中华肺部疾病杂志(电子版), 2019, 12(6): 776-779.
21
Vizoso FJ, Eiro N, Cid S, et al. Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine[J]. Int J Mol Sci, 2017, 18(9): 1852.
22
Park OH, Ha H, Lee Y, et al. Endoribonucleolytic cleavage of m(6)A-containing RNAs by RNase P/MRP complex[J]. Mol Cell, 2019, 74(3): 494-507.
23
Chen YG, Chen R, Ahmad S, et al. N6-Methyladenosine modification controls circular RNA immunity[J]. Mol Cell, 2019, 76(1): 96-109.
24
Chen RX, Chen X, Xia LP, et al. N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis[J]. Nat Commun, 2019, 10(1): 4695.
25
Yang Y, Fan X, Mao M, et al. Extensive translation of circular RNAs driven by N(6)-methyladenosine[J]. Cell Res, 2017, 27(5): 626-641.
[1] 刘政宏, 袁春銮. 乳腺癌患者血清外泌体中长链非编码RNA BC200的表达及临床意义[J]. 中华乳腺病杂志(电子版), 2024, 18(04): 212-216.
[2] 费扬, 赵晗希, 孙丽琴, 楼琴华, 胡骏程. 银杏叶提取物对糖尿病肾病患者的疗效及其对尿液外泌体miR-342-3p的干预研究[J]. 中华危重症医学杂志(电子版), 2024, 17(03): 219-224.
[3] 林琳, 田思萌, 于永华, 徐飞飞, 黄明莉. 干细胞及其外泌体治疗宫腔黏连的研究现状[J]. 中华妇幼临床医学杂志(电子版), 2024, 20(03): 271-275.
[4] 曹飞, 庞俊. 前列腺癌免疫微环境中免疫抑制性细胞分类及其作用机制[J]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(02): 121-125.
[5] 蔡定钦, 孙建国, 陈旭. 外泌体非编码RNAs与肺癌放射治疗的研究进展[J]. 中华肺部疾病杂志(电子版), 2024, 17(04): 655-658.
[6] 刘凌卉, 程铃, 张小雪, 肖敏. 环状RNA与肺部感染的研究进展[J]. 中华肺部疾病杂志(电子版), 2024, 17(01): 140-143.
[7] 孙海燕, 周士燕, 张杉杉, 张研, 张茜. 间充质干细胞及其外泌体在高原肺水肿中的潜在治疗机制研究进展[J]. 中华细胞与干细胞杂志(电子版), 2024, 14(03): 186-190.
[8] 刘杜先, 张杰东, 付鲁渝, 熊志强, 龚程, 张小雅, 高明悦, 孟俊宏, 刘兰侠. 沉默circXPO1抑制肝癌细胞恶性生物学行为[J]. 中华细胞与干细胞杂志(电子版), 2024, 14(03): 159-166.
[9] 陈俊秋, 邬绿莹, 马予洁, 林娜, 刘飞, 陈津. 基于lncRNA微阵列芯片技术探索间充质干细胞外泌体增强小鼠胰岛β细胞抗低氧损伤的潜在机制[J]. 中华细胞与干细胞杂志(电子版), 2024, 14(03): 129-136.
[10] 梁国豪, 张茜, 张研. 间充质干细胞及其衍生物治疗高原低氧环境下心血管疾病的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2024, 14(02): 107-112.
[11] 仝心语, 谭凯, 白亮亮, 杜锡林. 外泌体在肝细胞癌诊疗中的应用[J]. 中华肝脏外科手术学电子杂志, 2024, 13(03): 384-388.
[12] 季鹏程, 鄂一民, 陆晨, 喻春钊. 循环外泌体相关生物标志物在结直肠癌诊断中的研究进展[J]. 中华结直肠疾病电子杂志, 2024, 13(04): 265-273.
[13] 史敬萱, 焦圆圆, 田景玮, 卓莉. 间充质干细胞来源外泌体治疗动物糖尿病肾脏病的效果:Meta分析[J]. 中华肾病研究电子杂志, 2024, 13(02): 79-86.
[14] 辛强, 朱文豪, 何川, 李文臣, 陈勃, 王海峰. 神经胶质细胞来源的外泌体miRNAs对创伤性颅脑损伤后神经炎症的影响[J]. 中华神经创伤外科电子杂志, 2024, 10(03): 169-173.
[15] 蒲丹, 龙煊, 周玉龙, 李甘霖. 血清外泌体miR-224对结直肠癌肝转移患者射频消融治疗后复发的预测价值[J]. 中华消化病与影像杂志(电子版), 2024, 14(01): 45-52.
阅读次数
全文


摘要