切换至 "中华医学电子期刊资源库"

中华肺部疾病杂志(电子版) ›› 2021, Vol. 14 ›› Issue (03) : 332 -334. doi: 10.3877/cma.j.issn.1674-6902.2021.03.017

临床研究

MOB1表达水平与非小细胞肺癌切除术后疾病进展风险的相关性
胡守军1,(), 李文涛2, 孙仲涛1   
  1. 1. 236000 安徽,安徽医科大学附属阜阳人民医院胸外科
    2. 200030 上海,上海交通大学附属上海市胸科医院胸外科
  • 收稿日期:2021-02-07 出版日期:2021-06-25
  • 通信作者: 胡守军

Correlation between MOB1 expression level and risk of disease progression after resection of non-small cell lung cancer

Shoujun Hu1(), Wentao Li2, Zhongtao Sun1   

  • Received:2021-02-07 Published:2021-06-25
  • Corresponding author: Shoujun Hu
引用本文:

胡守军, 李文涛, 孙仲涛. MOB1表达水平与非小细胞肺癌切除术后疾病进展风险的相关性[J]. 中华肺部疾病杂志(电子版), 2021, 14(03): 332-334.

Shoujun Hu, Wentao Li, Zhongtao Sun. Correlation between MOB1 expression level and risk of disease progression after resection of non-small cell lung cancer[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2021, 14(03): 332-334.

目的

探讨单极纺锤体-结合蛋白1(MOB1)表达水平与非小细胞肺癌(NSCLC)切除术后疾病进展风险的相关性。

方法

选择2018年1月至2019年9月于我院就诊的85例NSCLC患者。收集患者临床资料,影像学资料,病理学资料及MOB1表达水平;两组患者均行NSCLC切除术,术后随访1年,根据患者疾病进展情况分为进展组和非进展组。分析MOB1表达水平与NSCLC切除术后疾病进展风险的相关性。

结果

随访1年,截至末次随访,共有12例患者因不同原因失访,最终纳入73例NSCLC切除术后患者,其中26例患者出现疾病进展为进展组,47例未出现疾病进展定义为无进展组。进展组T4分期、淋巴转移比例高于未进展组(P<0.05),MOB1表达水平、MLD E/I、VI-850/-950E-I低于未进展组(P<0.05),多因素Logistic回归分析显示淋巴转移(OR=2.570)、T分期(OR=2.096)、MOB1(OR=4.931)是NSCLC癌切除术后疾病进展风险的独立影响因素,ROC曲线分析显示,MOB1 AUC为0.835。

结论

MOB1表达水平在NSCLC疾病进展患者中低表达。

表1 两组患者一般资料比较[n(%),(±s)]
表2 多因素Logistic分析结果
表3 MOB1表达水平预测NSCLC切除术后疾病进展风险的效能
1
Lee SS, Cheah YK. The interplay between microRNAs and cellular components of tumour microenvironment (TME) on non-small-cell lung cancer (NSCLC) progression[J]. J Immunol Res, 2019, 19(1): 3046379.
2
Nitanda H, Taguchi R, Yanagihara A, et al. [Surgical outcome of sublobar resection in high-risk patients with non-small cell lung cancer][J]. Kyobu Geka, 2019, 72(1): 17-22.
3
Dong S, Roberts SA, Chen S, et al. Survival after lobectomy versus sub-lobar resection in elderly with stage I NSCLC: a meta-analysis[J]. BMC Surg, 2019, 19(1): 38.
4
Liu J, Shi Z, Ma Y, et al. MOB1 inhibits malignant progression of colorectal cancer by targeting PAK2[J]. Onco Targets Ther, 2020, 13(1): 8803-8811.
5
Zhang J, Wu L, Lian C, et al. Nitidine chloride possesses anticancer property in lung cancer cells through activating Hippo signaling pathway[J]. Cell Death Discov, 2020, 6(1): 91.
6
Ando N, Tanaka K, Otsubo K, et al. Association of Mps one binder kinase activator 1 (MOB1) expression with poor disease-free survival in individuals with non-small cell lung cancer[J]. Thorac Cancer, 2020, 11(10): 2830-2839.
7
Dietel M, Bubendorf L, Dingemans AM, et al. Diagnostic procedures for non-small-cell lung cancer (NSCLC): recommendations of the European expert group[J]. Thorax, 2016, 71(2): 177-184.
8
非小细胞肺癌辅助治疗胸外科共识专家组. 非小细胞肺癌术后辅助治疗中国胸外科专家共识(2018版)[J]. 中国肺癌杂志,2018, 21(10): 731-737.
9
Jonna S, Subramaniam DS. Molecular diagnostics and targeted therapies in non-small cell lung cancer (NSCLC): an update[J]. Discov Med, 2019, 27(148): 167-170.
10
Tandberg DJ, Tong BC, Ackerson BG, et al. Surgery versus stereotactic body radiation therapy for stage I non-small cell lung cancer: A comprehensive review[J]. Cancer, 2018, 124(4): 667-678.
11
Gundogdu R, Hergovich A. MOB (Mps one Binder) proteins in the Hippo pathway and cancer[J]. Cells, 2019, 8(6): 569.
12
Kato W, Nishio M, To Y, et al. MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner[J]. Genes Cells, 2019, 24(7): 485-495.
13
Yang H, Hu J, Chen J, et al. RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer[J]. Med Oncol, 2020, 37(9): 84.
14
Song J, Wang T, Chi X, et al. Kindlin-2 inhibits the Hippo signaling pathway by promoting degradation of MOB1[J]. Cell Rep, 2019, 29(11): 3664-3677.
15
Sasaki H, Kawano O, Endo K, et al. Human MOB1 expression in non-small-cell lung cancer[J]. Clin Lung Cancer, 2007, 8(4): 273-276.
16
Otsubo K, Goto H, Nishio M, et al. MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation[J]. Oncogene, 2017, 36(29): 4201-4211.
17
Taha Z, Janse van Rensburg HJ, Yang X. The Hippo pathway: immunity and cancer[J]. Cancers (Basel), 2018, 10(4): 94.
18
Ma S, Meng Z, Chen R, et al. The Hippo pathway: biology and pathophysiology[J]. Annu Rev Biochem, 2019, 88: 577-604.
19
Zheng Y, Pan D. The Hippo signaling pathway in development and disease[J]. Dev Cell, 2019, 50(3): 264-282.
20
Misra JR, Irvine KD. The Hippo signaling network and its biological functions[J]. Annu Rev Genet, 2018, 52(1): 65-87.
21
Boopathy GTK, Hong W. Role of Hippo pathway-YAP/TAZ signaling in angiogenesis[J]. Front Cell Dev Biol, 2019, 7(1): 49.
22
Driskill JH, Pan D. The Hippo pathway in liver homeostasis and pathophysiology[J]. Annu Rev Pathol, 2021, 16(1): 299-322.
23
Rausch V, Hansen CG. The Hippo pathway, YAP/TAZ, and the plasma membrane[J]. Trends Cell Biol, 2020, 30(1): 32-48.
24
Yamauchi T, Moroishi T. Hippo pathway in mammalian adaptive immune system[J]. Cells, 2019, 8(5): 398.
25
Kulaberoglu Y, Lin K, Holder M, et al. Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control[J]. Nat Commun, 2017, 8(1): 695.
26
Kim E, Kang JG, Kang MJ, et al. O-GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activity[J]. Proc Natl Acad Sci USA, 2020, 117(25): 14259-14269.
27
Hergovich A. Hippo signaling in mitosis: An updated view in light of the MEN pathway[J]. Methods Mol Biol, 2017, 1505(1): 265-277.
28
Zhang G, Dai S, Chen Y, et al. Aqueous extract of Taxus chinensis var. mairei regulates the Hippo-YAP pathway and promotes apoptosis of non-small cell lung cancer via ATF3 in vivo and in vitro[J]. Biomed Pharmacother, 2021, 138(1): 111506.
[1] 池畔, 黄胜辉. 中国腹腔镜直肠癌根治术30年来的巨大进步[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 596-600.
[2] 李玲, 刘亚, 李培玲, 张秀敏, 李萍. 直肠癌患者术后肠道菌群的变化与抑郁症相关性研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 607-610.
[3] 赵梓竣, 兰运升. 改良一针法末端回肠造口术对低位直肠癌保肛术后应激反应及安全性的影响[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 611-614.
[4] 梁孟杰, 朱欢欢, 王行舟, 江航, 艾世超, 孙锋, 宋鹏, 王萌, 刘颂, 夏雪峰, 杜峻峰, 傅双, 陆晓峰, 沈晓菲, 管文贤. 联合免疫治疗的胃癌转化治疗患者预后及术后并发症分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 619-623.
[5] 赵林娟, 吕婕, 王文胜, 马德茂, 侯涛. 超声引导下染色剂标记切缘的梭柱型和圆柱型保乳区段切除术的效果研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 634-637.
[6] 孟令凯, 李大勇, 王宁, 王桂明, 张炳南, 李若彤, 潘立峰. 袖状胃切除术对肥胖伴2型糖尿病大鼠的作用及机制研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 638-642.
[7] 刘海旺, 施海, 尚利峰. 不同吻合器在腹腔镜远端胃癌根治术Roux-en-Y式吻合中的应用对比[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 643-646.
[8] 赖全友, 高远, 汪建林, 屈士斌, 魏丹, 彭伟. 三维重建技术结合腹腔镜精准肝切除术对肝癌患者术后CD4+、CD8+及免疫球蛋白水平的影响[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 651-654.
[9] 唐梅, 周丽, 牛岑月, 周小童, 王倩. ICG荧光导航的腹腔镜肝切除术临床意义[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 655-658.
[10] 王兴, 文阳辉, 姚戈冰, 郭平学, 杨自华. ICG荧光腹腔镜下胆囊切除术的临床应用[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 663-666.
[11] 康婵娟, 张海涛, 翟静洁. 胰管支架置入术治疗急性胆源性胰腺炎的效果及对患者肝功能、炎症因子水平的影响[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 667-670.
[12] 张超, 张珍, 马梁, 穆欢欢, 刘彩玲. 腹腔镜胰十二指肠切除术术后C级胰瘘患者临床特征及影响因素研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 675-678.
[13] 黄建, 胡安丽, 王建平. 不同手术入路的骶前囊肿切除术单中心回顾性队列研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 683-686.
[14] 顾雯, 凌守鑫, 唐海利, 甘雪梅. 两种不同手术入路在甲状腺乳头状癌患者开放性根治性术中的应用比较[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 687-690.
[15] 石静, 陈龙舟, 于倩, 高峥嵘, 陆澄. 腺体瓣成形术在病理性乳头溢液手术中的应用[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 691-693.
阅读次数
全文


摘要