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中华肺部疾病杂志(电子版) ›› 2021, Vol. 14 ›› Issue (03) : 328 -331. doi: 10.3877/cma.j.issn.1674-6902.2021.03.016

临床研究

呼出气一氧化氮联合特异性体质对毛细支气管炎患儿的预后意义
谢楚杏1,(), 张月娥1, 刘国军1, 刘芬1, 莫惠如1, 戴金星1, 赖茂1   
  1. 1. 523320 东莞,东莞市第八人民医院(东莞市儿童医院)儿科
  • 收稿日期:2021-03-07 出版日期:2021-06-25
  • 通信作者: 谢楚杏
  • 基金资助:
    东莞市科技局市级一般科研项目(2018507150281398)

Prognostic significance of exhaled nitric oxide combined with specific constitution in children with bronchiolitis

Chuxing Xie1(), Yuee Zhang1, Guojun Liu1   

  • Received:2021-03-07 Published:2021-06-25
  • Corresponding author: Chuxing Xie
引用本文:

谢楚杏, 张月娥, 刘国军, 刘芬, 莫惠如, 戴金星, 赖茂. 呼出气一氧化氮联合特异性体质对毛细支气管炎患儿的预后意义[J]. 中华肺部疾病杂志(电子版), 2021, 14(03): 328-331.

Chuxing Xie, Yuee Zhang, Guojun Liu. Prognostic significance of exhaled nitric oxide combined with specific constitution in children with bronchiolitis[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2021, 14(03): 328-331.

目的

探讨一氧化氮联合特异性体质对毛细支气管炎患儿预后的影响。

方法

收集2018年7月至2019年12月东莞市儿童医院确诊的91例毛细支气管炎患儿,随访其半年内是否出现喘息,根据是否出现喘息分为喘息组29例和非喘息组62例,比较两组急性期及缓解期FeNO水平、过敏史、湿疹史、一级亲属过敏史、血液嗜酸性粒细胞比值、IgE等指标,分析FeNO和特异性体质对评估毛细支气管炎患儿预后的价值。

结果

喘息组IgE、嗜酸比值、急性期FeNO、缓解期FeNO均高于非喘息组;IgE、急性期FeNO、缓解期FeNO升高是患儿发生半年内出现喘息的危险因素,IgE、急性期FeNO、缓解期FeNO分别取值91.025、15.5、8.5时,其预测毛细支气管炎患儿预后半年内出现喘息的特异性最高。

结论

FeNO和特异性体质对评估毛细支气管炎患儿预后是否喘息均有较高的灵敏度和特异度,二者联合可明显增加曲线下面积,临床工作中可根据二项检查指导患儿治疗,提高患儿预后生活质量。

表1 两组的IgE、嗜酸、急性期及缓解期FeNO
表2 比较喘息组与非喘息组的临床资料
表3 喘息组与非喘息组的二项Logistics回归分析
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