切换至 "中华医学电子期刊资源库"

中华肺部疾病杂志(电子版) ›› 2021, Vol. 14 ›› Issue (06) : 745 -748. doi: 10.3877/cma.j.issn.1674-6902.2021.06.008

论著

长春瑞滨联合贝伐单抗治疗非小细胞肺癌的临床分析
施汪添翼1,(), 吴菁1, 缪晨婷1   
  1. 1. 215200 江苏,苏州市第九人民医院肿瘤内科
  • 收稿日期:2021-08-12 出版日期:2021-12-25
  • 通信作者: 施汪添翼
  • 基金资助:
    江苏省科技计划项目(201808995-SBE2018750244)

Clinical analysis of vinorereabine combined with bevacizumab in non-small cell cancer patients

Wangtianyi Shi1,(), Jing Wu1, Chenting Miao1   

  1. 1. Department of Oncology, Suzhou Ninth People′s Hospital, Suzhou 215200, China
  • Received:2021-08-12 Published:2021-12-25
  • Corresponding author: Wangtianyi Shi
引用本文:

施汪添翼, 吴菁, 缪晨婷. 长春瑞滨联合贝伐单抗治疗非小细胞肺癌的临床分析[J]. 中华肺部疾病杂志(电子版), 2021, 14(06): 745-748.

Wangtianyi Shi, Jing Wu, Chenting Miao. Clinical analysis of vinorereabine combined with bevacizumab in non-small cell cancer patients[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2021, 14(06): 745-748.

目的

分析长春瑞滨联合贝伐单抗治疗非小细胞肺癌(NSCLC)的临床疗效及生存情况。

方法

选择我院2017年4月至2020年3月接诊的42例NSCLC患者作为观察对象,依据临床治疗方案将患者分为观察组22例和对照组20例,给予对照组患者顺铂+长春瑞滨治疗,观察组患者在对照组基础上联合贝伐单抗治疗。评估两组患者治疗2周后的临床疗效、血清肿瘤因子[血清血管生成素样蛋白2(ANGPTL2)、抗菌肽人类阳离子抗菌蛋白18(hCAP18)及血清癌胚抗原(CEA)]水平、药物不良反应及12个月随访后的生存情况。

结果

观察组疾病控制率(81.82%)高于对照组(60.00%),差异有统计学意义(P<0.05);治疗后,两组患者的血清hCAP18、CEA及ANGPTL2水平均低于治疗前,且观察组较对照组更低,差异有统计学意义(P<0.05);观察组1年生存率(77.27%)高于对照组(45.00%),差异具有统计学意义(P<0.05);两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。

结论

给予NSCLC患者长春瑞滨联合贝伐单抗治疗,有助于改善患者的临床疗效,提高患者的疾病控制率,降低患者的血清hCAP18、CEA及ANGPTL2水平,提高患者的1年生存率,且安全性较好。

Objective

To analyze the clinical efficacy and survival of vinorereabine combined with bevacizumab for non-small cell lung cancer (NSCLC).

Methods

42 cases with NSCLC treated by our hospital from April 2017 to March 2020 were collected for this study. According to the clinical treatment, all of the cases were divided into observation group (22 cases) and control group (20 cases). In control group, patient with cisplatin plus vinorereabine. In observation group, patients treated combined with bevacizumab on a control basis. The clinical efficacy of two groups was evaluated after 2 weeks of treatment, serum tumor factors [serum angiopoietin-like protein 2 (ANGPTL2), antimicrobial peptide human cationic antimicrobial protein 18 (hCAP18) and serum carcincoembryonic antigen (CEA)] levels, adverse drug effects, and survival after 12-month follow-up.

Results

In observation group, the disease control rate was higher than control group (P<0.05). After treatment, the serum hCAP18, CEA and ANGPTL2 levels were lower than before, and the observation group was lower than control group(P<0.05). The 1-year survival rate, observation group was higher than control group (P<0.05). There was no significant difference in the incidence of adverse reactions in two groups(P>0.05).

Conclusion

Vinorereabine combined with bevacizumab in NSCLC patients, to improve the clinical efficacy of patients, improve the disease control rate of patients, reduce the serum levels of hCAP18, CEA and ANGPTL2 in patients, improve the 1-year survival rate of patients, and better safety.

表1 两组患者的血清肿瘤标志物水平比较(±s)
1
李慧婷,莫冉冉,宋 鹏,等. 非小细胞肺癌免疫检查点抑制剂治疗进展[J/CD]. 中华肺部疾病杂志(电子版), 2019, 12(3): 382-386.
2
陈宏达,郑荣寿,王 乐,等. 2019年中国肿瘤流行病学研究进展[J]. 中华疾病控制杂志2020, 24(4): 373-379.
3
邓小茜,戈 伟. SBRT与IMRT治疗早期非小细胞肺癌的疗效与生存情况分析[J]. 武汉大学学报(医学版), 2020, 41(5): 754-757.
4
Socinski MA, Jotte RM, Cappuzzo F, et al. Atezolizumab for first-line treatment of metastatic nonsquamous NSCLC[J]. N Engl J Med, 2018, 378(24): 2288-2301.
5
韩文杰,刘 军,孙永臣. 红参发酵产物联合长春瑞滨及顺铂化疗方案治疗晚期非小细胞肺癌患者的疗效[J]. 癌症进展2020, 18(7): 694-698.
6
Proto C, Ferrara R, Signorelli D, et al. Choosing wisely first line immunotherapy in non-small cell lung cancer (NSCLC): what to add and what to leave out[J]. Cancer Treat Rev, 2019, 75(3): 39-51.
7
Saito H, Fukuhara T, Furuya N, et al. Erlotinib plus bevacizumab versus erlotinib alone in patients with EGFR-positive advanced non-squamous non-small-cell lung cancer (NEJ026): interim analysis of an open-label, randomised, multicentre, phase 3 trial [J]. Lancet Oncol, 2019, 20(5): 625-635.
8
黄 彬. 贝伐单抗和顺铂联合治疗非小细胞肺癌恶性胸腔积液的疗效评价[J]. 国际呼吸杂志2016, 36(11): 814-817.
9
Manzo A, Montanino A, Carillio G, et al. Angiogenesis Inhibitors in NSCLC[J]. Int J Mol Sci, 2017, 18(10): 114-116.
10
支修益,石远凯,于金明. 中国原发性肺癌诊疗规范(2015年版)[J]. 中华肿瘤杂志2015, 37(1): 67-78.
11
Reck M, Mok T, Nishio M, et al. Atezolizumab plus bevacizumab and chemotherapy in non-small-cell lung cancer (IMpower150): key subgroup analyses of patients with EGFR mutations or baseline liver metastases in a randomised, open-label phase 3 trial[J]. Lancet Respir Med, 2019, 7(5): 387-401.
12
Assoun S, Brosseau S, Steinmetz C, et al. Bevacizumab in advanced lung cancer: state of the art[J]. Future Oncol, 2017, 13(28): 2515-2535.
13
Russo AE, Priolo D, Antonelli G, et al. Bevacizumab in the treatment of NSCLC: patient selection and perspectives[J]. Lung Cancer (Auckl), 2017, 8(10): 259-269.
14
Alshangiti A, Chandhoke G, Ellis PM. Antiangiogenic therapies in non-small-cell lung cancer[J]. Curr Oncol, 2018, 25(7): S45-S58.
15
Masuda C, Yanagisawa M, Yorozu K, et al. Bevacizumab counteracts VEGF-dependent resistance to erlotinib in an EGFR-mutated NSCLC xenograft model [J]. Int J Oncol, 2017, 51(2): 425-434.
16
Ramalingam SS, Dahlberg SE, Belani CP, et al. Pemetrexed, bevacizumab,or the combination as maintenance therapy for advanced nonsquamous non-small-cell lung cancer: ECOG-ACRIN 5508[J]. J Clin Oncol, 2019, 37(26): 2360-2367.
17
李 航,王 莹,张春江,等. 肿瘤坏死因子相关诱导凋亡配体联合长春瑞滨联合干预诱导肺癌A549细胞凋亡及其机制[J]. 中华实验外科杂志2016, 33(1): 112-114.
18
宋小珍,贾亚辉,张跃强. 长春瑞滨联合阿帕替尼治疗中晚期非小细胞肺癌的临床疗效及预后观察[J]. 实用癌症杂志2020, 35(12): 1997-2000.
19
Herbst RS, Redman MW, Kim ES, et al. Cetuximab plus carboplatin and paclitaxel with or without bevacizumab versus carboplatin and paclitaxel with or without bevacizumab in advanced NSCLC (SWOG S0819): a randomised, phase 3 study[J]. Lancet Oncol, 2018, 19(1): 101-114.
20
Dhillon S, Syed YY. Atezolizumab first-line combination therapy: a review in metastatic nonsquamous NSCLC[J]. Target Oncol, 2019, 14(6): 759-768.
21
薛 琴,传锋彬,唐 甦. CT引导下125I粒子植入联合贝伐单抗对非小细胞肺癌的疗效[J]. 实用癌症杂志2020, 35(3): 418-420.
22
Manegold C, Dingemans AC, Gray JE, et al. The potential of combined immunotherapy and antiangiogenesis for the synergistic treatment of advanced NSCLC[J]. J Thorac Oncol, 2017, 12(2): 194-207.
23
Reck M, Wehler T, Orlandi F, et al. Safety and patient-reported outcomes of atezolizumab plus chemotherapy with or without bevacizumab versus bevacizumab plus chemotherapy in non-small-cell lung cancer[J]. J Clin Oncol, 2020, 38(22): 2530-2542.
24
Jiang T, Zhang Y, Li X, et al. EGFR-TKIs plus bevacizumab demonstrated survival benefit than EGFR-TKIs alone in patients with EGFR-mutant NSCLC and multiple brain metastases[J]. Eur J Cancer, 2019, 121(7): 98-108.
25
Wakelee HA, Dahlberg SE, Keller SM, et al. Adjuvant chemotherapy with or without bevacizumab in patients with resected non-small-cell lung cancer (E1505): an open-label, multicentre, randomised, phase 3 trial[J]. Lancet Oncol, 2017, 18(12): 1610-1623.
26
Reinmuth N, Bryl M, Bondarenko I, et al. PF-06439535 (a bevacizumab biosimilar) compared with reference bevacizumab (Avastin((R))), both plus paclitaxel and carboplatin, as first-line treatment for advanced non-squamous non-small-cell lung cancer: a randomized, double-blind study[J]. BioDrugs, 2019, 33(5): 555-570.
27
Reck M, Shankar G, Lee A, et al. Atezolizumab in combination with bevacizumab, paclitaxel and carboplatin for the first-line treatment of patients with metastatic non-squamous non-small cell lung cancer, including patients with EGFR mutations[J]. Expert Rev Respir Med, 2020, 14(2): 125-136.
28
Thatcher N, Goldschmidt JH, Thomas M, et al. Efficacy and Safety of the Biosimilar ABP 215 compared with bevacizumab in patients with advanced nonsquamous non-small cell lung cancer (MAPLE): A randomized, double-blind, phase Ⅲ study[J]. Clin Cancer Res, 2019, 25(7): 2088-2095.
29
Gridelli C, de Castro CJ, Dingemans AC, et al. Safety and efficacy of bevacizumab plus standard-of-care treatment beyond disease progression in patients with advanced non-small cell lung cancer: The AvaALL randomized clinical trial[J]. JAMA Oncol, 2018, 4(12): e183-e186.
30
Iyengar P, Wardak Z, Gerber DE, et al. Consolidative radiotherapy for limited metastatic non-small-cell lung cancer: a phase 2 randomized clinical trial[J]. JAMA Oncol, 2018, 4(1): e173-e175.
[1] 聂生军, 王钰, 王毅, 鲜小庆, 马生成. 复方倍他米松局部注射联合光动力疗法治疗小型瘢痕疙瘩的临床疗效观察[J]. 中华损伤与修复杂志(电子版), 2024, 19(05): 404-410.
[2] 唐虹, 周奇, 欧阳晓玲, 王永峰, 华宇, 郝小白, 李林霞. 腹膜外无张力吊带子宫悬吊术治疗盆腔脏器脱垂的疗效[J]. 中华疝和腹壁外科杂志(电子版), 2024, 18(03): 315-319.
[3] 杨万荣, 任治坤, 时新颍. 沙丁胺醇雾化吸入脾多肽治疗AECOPD的疗效分析[J]. 中华肺部疾病杂志(电子版), 2024, 17(04): 609-612.
[4] 赵蒙蒙, 黄洁, 余荣环, 王葆青. 过表达小GTP酶Rab32抑制非小细胞肺癌细胞侵袭性生长[J]. 中华肺部疾病杂志(电子版), 2024, 17(04): 512-518.
[5] 张桂萍, 丘勇林, 湛绮婷, 孙乐栋. 晚期非小细胞肺癌血清Ape1/Ref-1对放射性肺损伤发生的预测意义[J]. 中华肺部疾病杂志(电子版), 2024, 17(04): 519-523.
[6] 韩晓宇, 李柯育, 赵志菲, 高建平. SNHG17过表达对非小细胞肺癌切除术预后的意义[J]. 中华肺部疾病杂志(电子版), 2024, 17(04): 543-547.
[7] 刘松, 张进召, 贾艳云. 帕博利珠单抗治疗晚期非小细胞肺癌反应降低与抗生素预处理的关系[J]. 中华肺部疾病杂志(电子版), 2024, 17(04): 553-557.
[8] 李多, 郝昭昭, 陈延伟, 南岩东. 血清PTX3表达与非小细胞肺癌骨转移的相关性分析[J]. 中华肺部疾病杂志(电子版), 2024, 17(04): 558-562.
[9] 陈旭, 牛凯, 孙建国. 放疗联合免疫治疗对驱动基因阴性NSCLC的困惑分析及应对策略[J]. 中华肺部疾病杂志(电子版), 2024, 17(03): 341-348.
[10] 杨静, 附舰, 康艳霞. 血浆ctDNA T790M突变和总代谢肿瘤体积对晚期EGFR突变NSCLC患者TKIs治疗及预后意义[J]. 中华肺部疾病杂志(电子版), 2024, 17(03): 379-384.
[11] 危用洋, 黄俊甫, 辛万鹏, 易思清, 涂书举, 方康, 李勇, 肖卫东. 三种术式治疗胰腺颈体部良性或低度恶性肿瘤的临床疗效分析[J]. 中华肝脏外科手术学电子杂志, 2024, 13(04): 515-519.
[12] 黄福秀, 张宁宁, 李晨阳, 李淑玲, 陈超. 单纯电切、单纯电凝与电凝电切术对扁平肠息肉疗效及不良事件发生率的影响[J]. 中华消化病与影像杂志(电子版), 2024, 14(04): 310-314.
[13] 徐清华, 张振林, 李浩. 清胰汤联合乌司他丁对急性胰腺炎患者肠道功能恢复及炎性因子水平的影响[J]. 中华消化病与影像杂志(电子版), 2024, 14(03): 253-257.
[14] 张迅夫, 马金山, 蒋云龙, 加纳提·托勒恒, 侯昌剑, 萨伍提·斯拉吉丁. GATA3在非小细胞肺癌组织中的表达及临床病理意义[J]. 中华胸部外科电子杂志, 2024, 11(03): 175-179.
[15] 李子健, 王锐, 钟云鹏, 张迪轩, 梁韵娟, 杨超, 何建行, 李树本. 自体肺移植术在胸部恶性肿瘤中的临床应用[J]. 中华胸部外科电子杂志, 2024, 11(03): 193-200.
阅读次数
全文


摘要