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中华肺部疾病杂志(电子版) ›› 2021, Vol. 14 ›› Issue (06) : 745 -748. doi: 10.3877/cma.j.issn.1674-6902.2021.06.008

论著

长春瑞滨联合贝伐单抗治疗非小细胞肺癌的临床分析
施汪添翼1,(), 吴菁1, 缪晨婷1   
  1. 1. 215200 江苏,苏州市第九人民医院肿瘤内科
  • 收稿日期:2021-08-12 出版日期:2021-12-25
  • 通信作者: 施汪添翼
  • 基金资助:
    江苏省科技计划项目(201808995-SBE2018750244)

Clinical analysis of vinorereabine combined with bevacizumab in non-small cell cancer patients

Wangtianyi Shi1,(), Jing Wu1, Chenting Miao1   

  1. 1. Department of Oncology, Suzhou Ninth People′s Hospital, Suzhou 215200, China
  • Received:2021-08-12 Published:2021-12-25
  • Corresponding author: Wangtianyi Shi
引用本文:

施汪添翼, 吴菁, 缪晨婷. 长春瑞滨联合贝伐单抗治疗非小细胞肺癌的临床分析[J/OL]. 中华肺部疾病杂志(电子版), 2021, 14(06): 745-748.

Wangtianyi Shi, Jing Wu, Chenting Miao. Clinical analysis of vinorereabine combined with bevacizumab in non-small cell cancer patients[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2021, 14(06): 745-748.

目的

分析长春瑞滨联合贝伐单抗治疗非小细胞肺癌(NSCLC)的临床疗效及生存情况。

方法

选择我院2017年4月至2020年3月接诊的42例NSCLC患者作为观察对象,依据临床治疗方案将患者分为观察组22例和对照组20例,给予对照组患者顺铂+长春瑞滨治疗,观察组患者在对照组基础上联合贝伐单抗治疗。评估两组患者治疗2周后的临床疗效、血清肿瘤因子[血清血管生成素样蛋白2(ANGPTL2)、抗菌肽人类阳离子抗菌蛋白18(hCAP18)及血清癌胚抗原(CEA)]水平、药物不良反应及12个月随访后的生存情况。

结果

观察组疾病控制率(81.82%)高于对照组(60.00%),差异有统计学意义(P<0.05);治疗后,两组患者的血清hCAP18、CEA及ANGPTL2水平均低于治疗前,且观察组较对照组更低,差异有统计学意义(P<0.05);观察组1年生存率(77.27%)高于对照组(45.00%),差异具有统计学意义(P<0.05);两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。

结论

给予NSCLC患者长春瑞滨联合贝伐单抗治疗,有助于改善患者的临床疗效,提高患者的疾病控制率,降低患者的血清hCAP18、CEA及ANGPTL2水平,提高患者的1年生存率,且安全性较好。

Objective

To analyze the clinical efficacy and survival of vinorereabine combined with bevacizumab for non-small cell lung cancer (NSCLC).

Methods

42 cases with NSCLC treated by our hospital from April 2017 to March 2020 were collected for this study. According to the clinical treatment, all of the cases were divided into observation group (22 cases) and control group (20 cases). In control group, patient with cisplatin plus vinorereabine. In observation group, patients treated combined with bevacizumab on a control basis. The clinical efficacy of two groups was evaluated after 2 weeks of treatment, serum tumor factors [serum angiopoietin-like protein 2 (ANGPTL2), antimicrobial peptide human cationic antimicrobial protein 18 (hCAP18) and serum carcincoembryonic antigen (CEA)] levels, adverse drug effects, and survival after 12-month follow-up.

Results

In observation group, the disease control rate was higher than control group (P<0.05). After treatment, the serum hCAP18, CEA and ANGPTL2 levels were lower than before, and the observation group was lower than control group(P<0.05). The 1-year survival rate, observation group was higher than control group (P<0.05). There was no significant difference in the incidence of adverse reactions in two groups(P>0.05).

Conclusion

Vinorereabine combined with bevacizumab in NSCLC patients, to improve the clinical efficacy of patients, improve the disease control rate of patients, reduce the serum levels of hCAP18, CEA and ANGPTL2 in patients, improve the 1-year survival rate of patients, and better safety.

表1 两组患者的血清肿瘤标志物水平比较(±s)
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