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中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (03) : 349 -351. doi: 10.3877/cma.j.issn.1674-6902.2023.03.010

临床研究

血清IL-34、SP-D、CXCL17在甲型流感病毒性肺炎患者中表达及临床意义
肖慧, 徐维国(), 范小兵, 李厚衡   
  1. 621000 绵阳,电子科技大学医学院附属绵阳医院·绵阳市中心医院呼吸与危重症医学科
  • 收稿日期:2022-11-19 出版日期:2023-06-25
  • 通信作者: 徐维国
  • 基金资助:
    北京白求恩公益基金会资助项目(SCZ057CS)

Expression and clinical significance of serum IL-34, SP-D and CXCL17 in patients with influenza A virus pneumonia

Hui Xiao, Weiguo Xu(), Xiaobing Fan   

  • Received:2022-11-19 Published:2023-06-25
  • Corresponding author: Weiguo Xu
引用本文:

肖慧, 徐维国, 范小兵, 李厚衡. 血清IL-34、SP-D、CXCL17在甲型流感病毒性肺炎患者中表达及临床意义[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 349-351.

Hui Xiao, Weiguo Xu, Xiaobing Fan. Expression and clinical significance of serum IL-34, SP-D and CXCL17 in patients with influenza A virus pneumonia[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(03): 349-351.

目的

分析甲型流感病毒性肺炎患者血清白介素-34(IL-34)、肺表面活性蛋白(SP-D)、CXC趋化因子配体17(CXCL17)的表达及临床意义。

方法

选取2017年1月至2020年12月我院收治的甲型流感病毒性肺炎患者108例,比较轻症、重症及不同预后血清IL-34、SP-D、CXCL17水平。分析预后危险因素。

结果

患者血清IL-34(26.17±5.59)pg/ml、SP-D(38.23±9.10)ng/ml、CXCL 17(10.43±2.71)ng/ml。重症者血清IL-34(38.43±10.72 vs. 16.29±3.88)pg/ml、SP-D(53.95±14.83 vs. 25.57±6.09)ng/ml、CXCL17(15.53±4.08 vs. 6.32±1.81) ng/ml高于轻度者(P<0.05)。Pearson相关性分析血清IL-34、SP-D、CXCL17分别与SOFA评分、APACHEⅡ评分呈正相关(P<0.05)。18例死亡SOFA评分、APACHEⅡ评分及血清IL-34、SP-D、CXCL17高于生存者(P<0.05)。多因素Logistic回归分析血清IL-34、SP-D、CXCL17升高是甲型流感病毒性肺炎患者死亡预后的危险因素(P<0.05)。ROC曲线显示IL-34、SP-D、CXCL17及联合检测甲型流感病毒性肺炎患者预后的AUC分别为0.812(95%CI:0.703~0.917,P<0.001)、0.792(95%CI:0.680~0.905,P<0.001)、0.804(95%CI:0.696~0.912,P<0.001)、0.905(95%CI:0.829~0.980,P<0.001)。

结论

甲型流感病毒性肺炎患者血清IL-34、SP-D、CXCL17上升,与病情及预后相关,联合检测判断患者预后具有临床意义。

表1 患者不同症状IL-34、SP-D、CXCL17
表3 预后危险因素分析
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