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中华肺部疾病杂志(电子版) ›› 2024, Vol. 17 ›› Issue (01) : 144 -147. doi: 10.3877/cma.j.issn.1674-6902.2024.01.032

综述

难治性哮喘的发病机制及诊治进展
陈华萍1, 陈晓龙1,(), 胡明冬1,()   
  1. 1. 400037 重庆,陆军(第三)军医大学第二附属医院老年医学与特勤医学科
  • 收稿日期:2023-12-17 出版日期:2024-02-25
  • 通信作者: 陈晓龙, 胡明冬
  • 基金资助:
    国家重点研发计划(2020YFC2008900,2020YFC2008903); 陆军军医大学科技创新能力提升专项项目(青年培育项目)(2022XQN33)

Pathogenesis and progress in diagnosis and treatment of refractory asthma

Huaping Chen, Xiaolong Chen(), Mingdong Hu()   

  • Received:2023-12-17 Published:2024-02-25
  • Corresponding author: Xiaolong Chen, Mingdong Hu
引用本文:

陈华萍, 陈晓龙, 胡明冬. 难治性哮喘的发病机制及诊治进展[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(01): 144-147.

Huaping Chen, Xiaolong Chen, Mingdong Hu. Pathogenesis and progress in diagnosis and treatment of refractory asthma[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2024, 17(01): 144-147.

支气管哮喘(bronchial asthma)是一种由嗜酸细胞、肥大细胞及中性粒细胞等多种细胞组分参与的慢性气道炎症性疾病,以气道高反应性和可逆气流受限为主要临床特征[1,2,3,4]。支气管哮喘大部分经糖皮质激素(inhaled corticosteroid, ICS)联合长效β受体激动剂(long acting beta agonist, LABA)吸入治疗得到有效控制。3%~10%支气管哮喘经中高等剂量ICS与LABA治疗,联用控制性药物规范治疗6个月,症状无法得到很好控制,即为难治性哮喘(refractory asthma, RA)[5]。哮喘流行病学调查报道,我国哮喘人群中14周岁以上难治性哮喘占5.99%,难治性哮喘急诊就诊率和住院率较轻中度哮喘高15~20倍,生活质量严重下降,死亡风险明显增高,家庭医疗花费增加,给家庭及社会造成了巨大负担[6,7]

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