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中华肺部疾病杂志(电子版) ›› 2024, Vol. 17 ›› Issue (01) : 140 -143. doi: 10.3877/cma.j.issn.1674-6902.2024.01.031

综述

环状RNA与肺部感染的研究进展
刘凌卉1,(), 程铃2, 张小雪3, 肖敏3   
  1. 1. 610000 成都,四川大学华西医院呼吸与危重症科
    2. 610000 成都,成都天使儿童医院儿童内科
    3. 610000 成都,成都天使儿童医院呼吸内科
  • 收稿日期:2023-10-19 出版日期:2024-02-25
  • 通信作者: 刘凌卉
  • 基金资助:
    国家重点研发计划课题(2017YFC1308504)

Research progress of circular RNA and pulmonary infection

Linghui Liu(), Ling Cheng, Xiaoxue Zhang   

  • Received:2023-10-19 Published:2024-02-25
  • Corresponding author: Linghui Liu
引用本文:

刘凌卉, 程铃, 张小雪, 肖敏. 环状RNA与肺部感染的研究进展[J]. 中华肺部疾病杂志(电子版), 2024, 17(01): 140-143.

Linghui Liu, Ling Cheng, Xiaoxue Zhang. Research progress of circular RNA and pulmonary infection[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2024, 17(01): 140-143.

肺部感染是由病原微生物、理化因素、免疫损伤、过敏或各种损伤因素引起终末气道、肺泡及肺间质炎症,临床以病原体感染所致的细菌性肺炎最为多见[1]。肺部感染常见的临床症状有畏寒、发热、咳嗽等,属于临床常见的呼吸系统疾病。肺部感染在伴有基础疾病的老年人以及免疫功能低下人群中最为常见,若患者得不到及时治疗会引起肺损伤,造成病情迁延不愈,甚至诱发严重的并发症,严重者引起患者死亡[2,3]。寻找肺部感染性疾病患者潜在的有效生物标志物对治疗、控制疾病发展具有积极意义。微小RNA、短肽等传统生物标志物在感染性疾病诊断中应用广泛,但稳定性较差,存在较大的局限性。环状RNA分子(circular RNA, circRNA)是一种不同于线性RNAs的一种特殊的非编码共价闭合的单链RNA分子,具有独特的闭合环状结构[4,5]。circRNA不具有5′末端帽子和3′末端poly(A)尾巴,通过外显子环化或内含子环化,将3′和5′末端连接起来形成完整的环形结构,避免被核酸外切酶降解,因其半衰期较长而稳定性较强,同时具有组织表达特异性、疾病特异性等特点,成为当前RNA领域的研究热点[6,7,8,9]。研究表明,环状RNA分子(circular RNA, circRNA)在肿瘤、心血管疾病、神经系统疾病中均发挥重要作用[10,11,12]。目前,有关circRNA的研究多聚焦在肿瘤方面(肺癌),而肺炎、肺结核等作为肺部感染中最常见的疾病,与circRNA相关文献鲜有报道。本文阐述circRNA在肺部感染性疾病中的研究进展,旨在为临床诊断和治疗肺部感染性疾病提供理论依据。

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