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中华肺部疾病杂志(电子版) ›› 2024, Vol. 17 ›› Issue (02) : 264 -267. doi: 10.3877/cma.j.issn.1674-6902.2024.02.019

临床研究

COPD并发吸入性CAP危险因素及病原菌分析
宋素莉1,(), 贺英华1, 陈丽娟1   
  1. 1. 102100 北京,北京市延庆区医院(北京大学第三医院延庆医院)感染疾病科
  • 收稿日期:2023-10-11 出版日期:2024-04-25
  • 通信作者: 宋素莉
  • 基金资助:
    北京市科学技术委员会科研基金项目(z161100000516219)

Analysis of cap risk factors and pathogens of inhaled community-acquired pneumonia complicated by copd of chronic obstructive pulmonary disease

Suli Song(), Yinghua He, Lijuan Chen   

  • Received:2023-10-11 Published:2024-04-25
  • Corresponding author: Suli Song
引用本文:

宋素莉, 贺英华, 陈丽娟. COPD并发吸入性CAP危险因素及病原菌分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(02): 264-267.

Suli Song, Yinghua He, Lijuan Chen. Analysis of cap risk factors and pathogens of inhaled community-acquired pneumonia complicated by copd of chronic obstructive pulmonary disease[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2024, 17(02): 264-267.

目的

分析慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)并发吸入性社区获得性肺炎(community acquired pneumonia, CAP)危险因素及病原菌。

方法

选取2021年6月至2022年12月我院收治的192例COPD患者为对象,并发吸入性CAP 60例为观察组,未并发132例为对照组。收集患者临床资料,行痰培养明确病原微生物分布情况,采用多因素Logistic分析COPD并发吸入性CAP的影响因素。

结果

两组年龄、体质量指数(body mass index, BMI)、高血压、神经系统疾病、肠内喂养史、卧床、住养老院差异具有统计学意义(P<0.05);多因素Logistic回归分析显示:年龄(OR=1.184;P=0.029)、神经系统疾病(OR=8.079;P=0.006)、肠内喂养史(OR=27.303;P=0.003)、卧床(OR=7.337;P=0.014)、住养老院(OR=10.194;P=0.002)为COPD并发吸入性CAP的危险因素,BMI(OR=0.609;P=0.002)为COPD并发吸入性CAP的保护因素。痰培养阳性分离病原菌60株,其中革兰阴性杆菌42株(70.00%)、革兰阳性球菌15株(25.00%)、真菌3株(5.00%),包括铜绿假单胞菌24株(40.00%)、鲍曼不动杆菌3株(5.00%)、肺炎克雷伯菌12株(20.00%)、金黄色葡萄球菌9株(15.00%)、肺炎链球菌3株(5.00%)、白假丝酵母菌3株(5.00%)。

结论

高龄、体质量不足、神经系统疾病、肠内喂养史、卧床、住养老院为COPD并发吸入性CAP的危险因素,铜绿假单胞菌、肺炎克雷伯菌、金黄色葡萄球菌为COPD并发吸入性CAP的主要致病菌。

表1 两组CAP患者临床资料比较[n(%)]
表2 COPD并发吸入性CAP的多因素Logistic回归分析
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