切换至 "中华医学电子期刊资源库"

中华肺部疾病杂志(电子版) ›› 2024, Vol. 17 ›› Issue (06) : 1027 -1030. doi: 10.3877/cma.j.issn.1674-6902.2024.06.035

综述

巨噬细胞参与免疫调节机制在肺动脉高压中的影响及相关纳米材料的研究进展
向青1, 龚道辉2, 赵才林1, 张硕辛1, 秦蘅1, 刘禹1   
  1. 1.400037 重庆,陆军(第三)军医大学第二附属医院呼吸与危重症医学科
    2.400037 重庆,陆军(第三)军医大学第二附属医院全军呼吸研究所
  • 收稿日期:2024-07-18 出版日期:2024-12-25
  • 基金资助:
    重庆市英才-市自然科学基金重点项目(No.cstc2021ycjh-bgzxm0011)基于生成式人工智能的慢阻肺早期精准防控系统的研发和慢阻肺早期干预策略的建立(2024GGXM001)

Influence of macrophages on the immunomodulatory mechanism in pulmonary hypertension and the research progress of related nanomaterials

Qing Xiang, Daohui Gong, Cailin Zhao, Shuoxin Zhang, heng qin, yu liu   

  • Received:2024-07-18 Published:2024-12-25
引用本文:

向青, 龚道辉, 赵才林, 张硕辛, 秦蘅, 刘禹. 巨噬细胞参与免疫调节机制在肺动脉高压中的影响及相关纳米材料的研究进展[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(06): 1027-1030.

Qing Xiang, Daohui Gong, Cailin Zhao, Shuoxin Zhang, heng qin, yu liu. Influence of macrophages on the immunomodulatory mechanism in pulmonary hypertension and the research progress of related nanomaterials[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2024, 17(06): 1027-1030.

1
中华医学会呼吸病学分会肺栓塞与肺血管病学组,中国医师协会呼吸医师分会肺栓塞与肺血管病工作委员会,全国肺栓塞与肺血管病防治协作组,等.中国肺动脉高压诊断与治疗指南(2021 版)[J].中华医学杂志,2021,101(1):11-51.
2
Galiè N,Humbert M,Vachiery JL,et al.2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension:the joint task force for the diagnosis and treatment of pulmonary hypertension of the european society of cardiology (ESC) and the european respiratory society (ERS):endorsed by:association for european paediatric and congenital cardiology (AEPC),international society for heart and lung transplantation (ISHLT)[J].Eur Heart J,2016,37(1):67119.
3
Kovacs G,Berghold A,Scheidl S,et al.Pulmonary arterial pressure during rest and exercise in healthy subjects:a systematic review[J].Eur Respir J,2009,34(4):888894.
4
Simonneau G,Montani D,Celermajer DS,et al.Haemodynamic definitions and updated clinical classification of pulmonary hypertension[J].Eur Respir J,2019,53(1):1801913.
5
Marc H,Gabor K,Marius MHr,et al.2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension[J].Eur Heart J,2022,43(38):3618-3731.
6
Angela B,Ayako M,Jason XJY.Pathophysiology and pathogenic mechanisms of pulmonary hypertension:Role of membrane receptors,ion channels and Ca2+ signaling[J].Physiol Reviews,2022,103(3):1827-1897.
7
Hoeper MM,McLaughlin VV,Barberá AJ ,et al.Initial combination therapy with ambrisentan and tadalafil and mortality in patients with pulmonary arterial hypertension:a secondary analysis of the results from the randomised,controlled AMBITION study[J].Lancet Respir Med,2016,4(11):894-901.
8
陈秋宏,杨 红,郑 琴,等.迷迭香酸对野百合碱诱导肺动脉高压大鼠的作用及机制[J].西南医科大学学报,2024,47(4):311-315.
9
Rabinovitch M,Guignabert C,Humbert M,et al.Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension[J].Circ Res,2014,115(1):165-175.
10
Savai R,Pullamsetti SS,Kolbe J,et al.Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension[J].Am J Respir Crit Care Med,2012,186(9):897-908.
11
Funk-Hilsdorf TC,Behrens F,Grune J,et al.Dysregulated immunity in pulmonary hypertension:From companion to composer[J].Front Physiol,2022,13:819145.
12
Pugliese SC,Kumar S,Janssen WJ,et al.A time-and compartmentspecific activation of lung macrophages in hypoxic pulmonary hypertension[J].J Immunol,2017,198(12):4802-4812.
13
Florentin J,Coppin E,Vasamsetti SB,et al.Inflammatory macrophage expansion in pulmonary hypertension depends upon mobilization of blood-borne monocytes[J].J Immunol,2018,200(10):3612-3625.
14
Park B,Suh M,Park JY,et al.Assessment of inflammation in pulmo-68 Ga-mannosylated human serum albuminnary artery hypertension by 68 Ga-mannosylated human serum albumin[J].Am J Respir Crit Care Med,2020,201(1):95-106.
15
Vergadi E,Chang MS,Lee C,et al.Early macrophage recruitment and alternative activation are critical for the development of hypoxiainduced pulmonary later hypertension[J].Circulation,2011,123(18):1986-1995.
16
Yunna C,Mengru H,Lei W,et al.Macrophage M1/M2 polarization[J].Eur J Pharmacol,2020,877:173090.
17
Fan Y,Hao Y,Gao D,et al.Phenotype and function of maerophagepolarizationinmonocrotaline-inducedpulmonary arteriahypertension rat model [J].Physiol Res,2021,70(2):213-226.
18
Tang C,Luo YM,Li S,et al.Characteristics of inflammationprocess in monocrotaline-induced pulmonary arterial hypertensionin rats [J].Biomed Pharmacother,2021,133:111081.
19
Michal T,Paulina M,Martyna J,et al.In the search for biomarkers of pulmonary arterial hypertension,are cytokines IL-2,IL-4,IL-6,IL-10,and IFN-Gamma the right indicators to use? [J].Int J Mol Sci,2023,24(18):13694.
20
Golembeski SM,West J,Tada Y,et al.Interleukin-6 causes mild pulmonary hypertension and augments hypoxia-induced pulmonary hypertension in mice[J].Chest,2005,128(6 Suppl):572S-573S.
21
Simpson CE,Chen JY,Damico RL,et al.Cellular sources ofinterleukin-6 and associations with clinical phenotypes and out-comes in pulmonary arterial hypertensionJ].Eur Respir J,2020,55(4):1901761.
22
Ranchoux B,Antigny F,Rucker-Martin C.Endothelial-to-mesenchymal transition in pulmonary hypertension[J].Circulation,2015,131(11):1006-1018.
23
Florentin J,Coppin E,Vasamsetti SB,et al.Inflammatory macrophage expansion in pulmonary hypertension depends upon mobilization of blood-borne monocytes[J].J Immunol,2018,200(10):3612-3625.
24
Bid S,Marcos E,Parpaleix A,et al.CCR2/CCR5-mediated macrophagesmooth muscle celcrosstalk inpulmonary hypertension[J].Eur Respir J,2019,54(4):1802308.
25
Amsellem V,lipskaia L,Abid S,et al.CCR5 as a treatmenttarget in pulmonary arterial hypertension[J].Circulation,2014,130(11):880-891.
26
Itoh T,Nagaya N,Ishibashiueda H,et al.Increasedplasma monocyte chemoattractant protein-l level in idiopathic pulmonary arterial hypertension[J].Respir,2010,11(2):158-163.
27
Eleni V,Chang MS,Lee CJ,et al.Early macrophage recruitment and alternative activation are critical for the later development of hypoxia-induced pulmonary hypertension[J].Circulation,2011,123(18):1986-1995.
28
任成山,卞士柱,胡明冬.肺动脉高压的成因及治疗新理念[J/CD].中华肺部疾病杂志(电子版),2023,16(1):1-5.
29
Dilliard SA,Siegwart DJ.Passive,active and endogenous organtargeted lipid and polymer nanoparticles for delivery of genetic drugs[J].Nat Rev Mater,2023,8(4):282-300.
30
Wu Y,Wan S,Yang S,et al.Macrophage cell membrane-based nanoparticles:a new promising biomimetic platform for targeted delivery and treatment[J].J Nanobiotechnology,2022,20(1):542.
31
Xu X,Kwong CHK,Lee JY,et al.“Zombie” macrophages for targeted drug delivery to treat acute pneumonia[J].ACS Applied Mater Interfaces,2023,15(24):29012-29022.
32
李 尚,吕婷婷,张子睿,等.基因治疗在肺动脉高压中的研究进展[J].江苏大学学报(医学版),2022,32(3):200-206.
33
Wang S,Chen Q,Zhao T,et al.Nanomedicine-based treatment:An emerging therapeutical strategy for pulmonary hypertension[N].Nano Research,2023,https:/ /doi.org/10.1007/s12274-022-5310-6.
34
Liu X,Wang G,You Z,et al.Inhibition of hypoxia-induced proliferation of pulmonary arterial smooth muscle cells by a mTOR siRNA-loaded cyclodextrin nanovector[J].Biomaterials,2014,35(14):4401-4416.
35
Corsi F,Carotenuto F,Dinardo P,et al.Harnessing inorganic nanoparticles to direct macrophage polarization for skeletal muscle regeneration[J].Nanomaterials(Basel),2020,10(10):1963.
36
鲍佳明,赵晨旭,孙凌云,等.基因工程改造巨噬细胞及其应用[J].中国免疫学杂志,2023,39(10):2062-2070.
37
李佳蕾,徐 昉,廖晓辉.抗氧化纳米材料在急性肾损伤治疗中的应用进展[J].中国急救医学,2022,42(1):72-75.
38
Yu M,Wu XC,Peng LY,et al.Inhibition of Bruton's tyrosine kinase alleviates monocrotaline-induced pulmonary arterial hypertension by modulating macrophage polarization [J].Oxid Med Cell Longev,2022,2022:6526036.
39
Takahiro HK,Naoki H,Takashi S.Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension[J].Proc Natl Acad Sci U S A,2015,112(20):E2677-2686.
40
Jia DL,Bai PY,Wan NF,et al.Niacin attenuates pulmonary hypertension through H-PGDS in macrophages[J].Circ Res,2020,127(10):1323-1336.
[1] 吴义刚, 潘裕民, 吴姗姗, 胡梦涓, 王一为, 张劲松, 乔莉. 左西孟旦治疗肺动脉高压合并右心衰竭患者疗效分析——Meta 分析[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(05): 385-391.
[2] 陈观梅, 左璇, 廖宝林. 慢性乙型肝炎新型免疫治疗研究进展[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(01): 7-10.
[3] 王阅, 杨园梦, 何德亿, 孟雯, 陈昕煜, 李飞, 卢展民, 陆海霞. 基于口腔微生态的龋病防治研究进展[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(06): 391-396.
[4] 陈天, 李歆, 刘开政, 邓永强. 口腔钛种植体成骨性能的研究进展[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(03): 200-205.
[5] 张诚实, 陈荣荣, 秦二云, 张青, 刘明, 冯契靓, 赵云峰. 动态测定血浆长链非编码RNA SOX2-OT在COPD 相关性肺动脉高压患者中的临床意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(06): 895-900.
[6] 宋新雅, 苏小慧, 卞士柱, 丁小涵. 吸入性药物治疗肺动脉高压的研究进展[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 831-835.
[7] 罗霞, 王宝梅, 李淑景, 杨英. 特发性肺动脉高压血清PCSK9表达及预后意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 585-589.
[8] 朱佑君, 付万垒, 毛杨, 李德峰. 细胞外基质相关标志物与成纤维细胞在肺动脉高压发展中的意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(03): 356-362.
[9] 张艺萱, 罗金丹, 葛小丽, 钟红琴. 先天性心脏病伴PH血清H-FABP、NT-proBNP与肺动脉内径、血流速度及PASP的关系[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(02): 252-255.
[10] 贾玲玲, 滕飞, 常键, 黄福, 刘剑萍. 心肺康复在各种疾病中应用的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 859-862.
[11] 吴欣, 袁晓晨, 沈慧, 秦建华. 三尖瓣反流速度评估肺动脉高压患者心脏结构改变的研究[J/OL]. 中华临床医师杂志(电子版), 2024, 18(03): 259-267.
[12] 陆天, 孙道萍. 调节性B细胞在多发性骨髓瘤中的研究进展[J/OL]. 中华诊断学电子杂志, 2024, 12(02): 133-137.
[13] 孟丽君, 宋芹, 邵莉, 李健. 系统性红斑狼疮合并肺动脉高压患者外周血T淋巴细胞亚群水平变化及临床意义[J/OL]. 中华诊断学电子杂志, 2024, 12(01): 38-43.
[14] 龚霄雷, 朱丽敏, 姜燕, 徐卓明. 急性右心室功能障碍的诊疗进展[J/OL]. 中华心脏与心律电子杂志, 2024, 12(03): 161-168.
[15] 孙冠超, 万军, 石卉. IgG相关食物不耐受与肠道免疫微环境相关性的研究进展[J/OL]. 中华胃肠内镜电子杂志, 2024, 11(03): 200-203.
阅读次数
全文


摘要