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中华肺部疾病杂志(电子版) ›› 2025, Vol. 18 ›› Issue (05) : 837 -840. doi: 10.3877/cma.j.issn.1674-6902.2025.05.034

综述

结缔组织病相关间质性肺疾病与炎症相关信号通路的研究进展
杜静怡1, 徐兴祥2,()   
  1. 1225003 扬州,江苏省苏北人民医院呼吸与危重症医学科
    2215100 苏州,江苏苏州明基医院呼吸与危重症医学科
  • 收稿日期:2025-04-10 出版日期:2025-10-25
  • 通信作者: 徐兴祥

Research progress on connective tissue disease associated interstitial lung disease and inflammation related signaling pathways

Jingyi Du, Xingxiang Xu()   

  • Received:2025-04-10 Published:2025-10-25
  • Corresponding author: Xingxiang Xu
引用本文:

杜静怡, 徐兴祥. 结缔组织病相关间质性肺疾病与炎症相关信号通路的研究进展[J/OL]. 中华肺部疾病杂志(电子版), 2025, 18(05): 837-840.

Jingyi Du, Xingxiang Xu. Research progress on connective tissue disease associated interstitial lung disease and inflammation related signaling pathways[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2025, 18(05): 837-840.

结缔组织病相关间质性肺疾病(connective tissue disease-associated interstitial lung disease, CTD-ILD)是结缔组织病(connective tissue disease, CTD)常见的肺部并发症,发病机制与异常免疫炎症反应密切相关。近年发现,Toll样受体(toll-like receptors, TLR)信号通路、环鸟苷酸-腺苷酸合成酶(cyclic gmp-amp synthase, cGAS)-干扰素基因刺激蛋白(stimulator of interferon genes, STING)-Ⅰ型干扰素信号通路及Janus激酶(janus kinase, JAK)/信号转导与转录激活因子(signal transducer and activator of transcription, STAT)途径等炎症相关信号通路在CTD-ILD发生发展中发挥关键作用。本文综述了这些信号通路分子机制及在CTD-ILD中的作用,以期为临床治疗提供新靶点。

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