切换至 "中华医学电子期刊资源库"

中华肺部疾病杂志(电子版) ›› 2026, Vol. 19 ›› Issue (02) : 303 -308. doi: 10.3877/cma.j.issn.1674-6902.2026.02.018

论著

577例儿童社区获得性肺炎临床特征及诊疗现状回顾性分析
汤亚南1, 刘晓亮2, 马秀英2, 赵璐珊2, 王丽颖2, 周鹏翔3,4, 盖晓燕5, 邢燕1,()   
  1. 1100191 北京,北京大学第三医院儿科
    2066000 河北,北京大学第三医院秦皇岛医院儿科
    3100191 北京,北京大学第三医院药学部
    4100191 北京,北京大学医学部药物评价中心
    5100191 北京,北京大学第三医院呼吸内科
  • 收稿日期:2025-12-04 出版日期:2026-04-25
  • 通信作者: 邢燕
  • 基金资助:
    北医-OPPO创新基金,创新资助项目A类,LM2024732(M2024571)

Retrospective analysis of clinical features and current status of diagnosis and treatment in 577 children with community-acquired pneumonia

Yanan Tang1, Xiaoliang Liu2, Xiuying Ma2, Lushan Zhao2, Liying Wang2, Pengxiang Zhou3,4, Xiaoyan Gai5, Yan Xing1,()   

  1. 1Department of Pediatrics, Peking University Third Hospital, Beijing 100191
    2Department of Pediatrics, Qinhuangdao Hospital of Peking University Third Hospital, Qinhuangdao City, Hebei Province, 066000
    3Department of Pharmacy, Peking University Third Hospital, Beijing 100191, China
    4Institute for drug evaluation, Peking University Health Science Center, Beijing 100191, China
    5Peking University Third Hospital Respiratory Medicine Department, Beijing 100191, China
  • Received:2025-12-04 Published:2026-04-25
  • Corresponding author: Yan Xing
引用本文:

汤亚南, 刘晓亮, 马秀英, 赵璐珊, 王丽颖, 周鹏翔, 盖晓燕, 邢燕. 577例儿童社区获得性肺炎临床特征及诊疗现状回顾性分析[J/OL]. 中华肺部疾病杂志(电子版), 2026, 19(02): 303-308.

Yanan Tang, Xiaoliang Liu, Xiuying Ma, Lushan Zhao, Liying Wang, Pengxiang Zhou, Xiaoyan Gai, Yan Xing. Retrospective analysis of clinical features and current status of diagnosis and treatment in 577 children with community-acquired pneumonia[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2026, 19(02): 303-308.

目的

分析综合医院儿科单中心住院儿童社区获得性肺炎(community-acquired pneumonia, CAP)诊疗数据,为提高儿科肺炎诊疗管理水平提供依据。

方法

回顾性分析2019年7月至2024年1月在北京大学第三医院秦皇岛医院儿科病房住院的577例肺炎患儿流行病学信息、临床特征、病原检测、肺部影像学、抗菌药物和糖皮质激素使用情况等。

结果

肺炎占儿科同期全部住院人数53.28%(577/1 083),患儿中位数年龄4(3,7)岁,住院日7 d(5,8)。577例CAP患儿中,重症肺炎35例(6.07%),行支气管镜治疗11例(1.91%)。573例(99.31%)患儿使用静脉抗菌药物,静脉输注疗程6 d(5,7)。静脉输注甲泼尼龙68例(11.78%),平均疗程4 d(3,5)。CAP患儿肺部影像学表现为点片状模糊阴影280例(48.52 %),大片状高密度阴影59例(10.22%),磨玻璃影8例(1.39%),左肺炎症97例(16.81%),右侧炎症134例(23.22 %),双侧炎症268例(46.45 %),胸腔积液1例( 0.17 %),肺不张3例(0.52%)。577例CAP患儿病原体检出阳性416例(72.10%),其中肺炎支原体(Mycoplasma pneumonia, MP)阳性272例(47.14%),腺病毒(Adenovirus, ADV)阳性56例(9.81%),乙型流感病毒(Influenza B virus, Ful B)阳性53例(9.28%)及甲型流感病毒(Influenza A virus, Flu A)阳性15例(4.56%),178例(30.85%)行痰培养,阳性3例(1.69%),均为肺炎克雷白杆菌(Klebsiella pneumoniae, KLP)。

结论

儿科住院患儿病种肺炎占优势,肺炎住院患儿年度波动大、轻症多,儿童CAP诊疗中在精准微生物检测方法、抗生素药物应用等存在一定问题。应提高病原学检测水平、加强抗菌药物使用监管,倡导儿童轻症肺炎门诊治疗优先。

Objective

To analyze the diagnosis and treatment data of children with community-acquired pneumonia (CAP) from a single-center pediatric department in a general hospital, and to provide a basis for improving the management of pediatric pneumonia.

Methods

A retrospective analysis was conducted on 577 children with pneumonia hospitalized in the pediatric ward of Qinhuangdao Hospital of Peking University Third Hospital from July 2019 to January 2024. Data on epidemiological information, clinical characteristics, pathogen detection, chest imaging findings, and the use of antimicrobial agents and glucocorticoids were collected.

Results

Pneumonia accounted for 53.28% (577/1 083) of all pediatric hospitalizations during the same period. The median age of the children was 4 years (3~7), and the median length of hospital stay was 7 days (5~8). Severe pneumonia accounted for 6.07% (35/577), and 1.91% (11/577) were transferred to a higher-level hospital for bronchoscopy treatment. Intravenous antimicrobial agents were administered to 99.31% of the children, with a median treatment duration of 6 days (5~7). Intravenous methylprednisolone was used in 68 cases (11.78%), with a median treatment duration of 4 days (3~5). The overall pathogen detection rate was 25.14% (416/1655). Among pathogens detected by serum IgM antibody testing, Mycoplasma pneumoniae had the highest positivity rate (272/577, 47.14%). Sputum culture was performed in 178 cases (30.74%, 178/579), with a positivity rate of only 1.69%. Pulmonary imaging findings in children with community-acquired pneumonia (CAP) included patchy fuzzy opacities in 280 cases (48.52%), large patchy high-density opacities in 59 cases (10.22%), ground-glass opacities in 8 cases (1.39%), left lung inflammation in 97 cases (16.81%), right lung inflammation in 134 cases (23.22%), bilateral inflammation in 268 cases (46.45%), pleural effusion in 1 case (0.17%), and atelectasis in 3 cases (0.52%). Pathogens were detected in 416 cases (72.10%). Among these, Mycoplasma pneumoniae (MP) was positive in 272 cases (47.14%), Adenovirus (ADV) in 56 cases (9.81%), Influenza B virus (Flu B) in 53 cases (9.28%), and Influenza A virus (Flu A) in 15 cases (4.56%). Sputum culture was performed in 178 cases (30.85%), with positive results in 3 cases (1.69%), all of which were Klebsiella pneumoniae.

Conclusion

Pneumonia is the predominant cause of hospitalization in the pediatric department. The annual number of pneumonia hospitalizations fluctuates significantly, with most cases being mild. Certain issues exist in areas such as precise microbiological detection methods and the application of antimicrobial agents. Efforts should be made to improve the level of etiological detection, strengthen the supervision of antimicrobial use, and promote the prioritization of outpatient management for children with mild pneumonia.

图1 图A为阳性呼吸道病原分布;图B为呼吸道病原体检测分布
表1 CAP患儿呼吸道病原学检测结果
图2 图A头孢类抗生素种类分布;图B抗菌药物使用方案分布
1
中华医学会儿科学分会呼吸学组,中华儿科杂志编辑委员会,中国医药教育协会儿科专业委员会. 儿童社区获得性肺炎管理指南(2024修订)[J]. 中华儿科杂志2024, 62(10): 920-930.
2
Meyer Sauteur PM. Childhood community-acquired pneumonia[J]. Eur J Pediatr, 2024, 183(3): 1129-1136.
3
Basile D, Sandelich S. Community-acquired pneumonia in children[J]. Emerg Med Clin North Am, 2025, 43(4): 567-584.
4
Pratt MTG, Abdalla T, Richmond PC, et al. Prevalence of respiratory viruses in community-acquired pneumonia in children: a systematic review and meta-analysis[J]. Lancet Child Adolesc Health, 2022, 6(8): 555-570.
5
胡家康,韩志英,张俊艳. 儿童社区获得性肺炎病原学特点分析[J]. 中国实用儿科杂志2023, 38(5): 381-385.
6
谢晓飞,郭亦男. 2 533例儿童社区获得性肺炎支原体感染的流行病学分析[J]. 中国妇幼保健2024, 39(7): 1260-1263.
7
曾苑,贾晓丹,宋哲. 儿童重症社区获得性肺炎的病原学特点及不良预后影响因素的预测模型构建[J]. 广东医学2025, 46(10): 1567-1572.
8
甘小琴,苏莉,王旭霞,等. 5岁以下儿童社区获得性肺炎病原谱及疾病负担研究进展[J]. 中国公共卫生2018, 41(11): 1471-1475.
9
罗燕萍,黄见可,肖昕,等. 儿童社区获得性肺炎病原学结果分析[J]. 中国临床医生杂志2024, 52(12): 1483-1486.
10
国家卫生健康委员会. 儿童肺炎支原体肺炎诊疗指南(2023年版)[J]. 新发传染病电子杂志2024, 9(1): 73-79.
11
Li QY, Zhou Q, Florez ID, et al. Short-course vs long-course antibiotic therapy for children with nonsevere community-acquired pneumonia: a systematic review and meta-analysis[J]. JAMA Pediatr, 2022, 176(12): 1199-1207.
12
Shalini S, Kendra S, Ran DG, et al. Antibiotic treatment duration for community-acquired pneumonia in children[J]. Can Fam Physician, 2023, 69(6): 400-402.
13
国家卫生健康委关于印发健康儿童行动提升计划(2021-2025年)的通知[J]. 中华人民共和国国家卫生健康委员会公报2021, (10): 28-32.
14
中华人民共和国国家卫生健康委员会,国家中医药局. 儿童社区获得性肺炎诊疗规范(2019年版)[J]. 中华临床感染病杂志2019, 12(1): 6-13.
15
Hart JH, Sakata T, Eve JR, et al. Diagnosis and treatment of pneumonia in urgent care clinics: Opportunities for improving care[J]. Open Forum Infect Dis, 2024, 11(3): ofae096.
16
Donà D, Brigadoi G, Grandinetti R, et al. Treatment of mild to moderate community-acquired pneumonia in previously healthy children: an Italian intersociety consensus[J]. Ital J Pediatr, 2024, 50(1): 217.
17
Liguoro I, Piccinin G, Praturlon I, et al. Complicated community-acquired pneumonia in children: An updated systematic review of literature and Meta-analysis[J]. Pediatr Pulmonol, 2025, 60(11): e71374.
18
KL, Yang JH, Tang ZY, et al. Clinical characteristics of Mycoplasma pneumoniae pneumonia in children during the post-coronavirus disease 2019 era: a retrospective study in Chongqing, China[J]. Transl Pediatr, 2025, 14(12): 3293-3304.
19
Korppi M. Antibiotic therapy in children with community-acquired pneumonia[J]. Acta Paediatr, 2021, 110(12): 3246-3250.
20
Rueda ZV, Aguilar Y, Maya MA, et al. Etiology and the challenge of diagnostic testing of community-acquired pneumonia in children and adolescents[J]. BMC Pediatr, 2022, 22(1): 169.
21
朱德昊,石建伟,黄蛟灵,等. 疾病谱视角下社区儿科的需求研究:以上海市崇明区为例[J]. 中国全科医学2021, 24(19): 2477-2483.
22
张利峰,张凝凝,秦秀群,等. 分级诊疗背景下上呼吸道感染儿童的就医行为及影响因素分析[J]. 中国全科医学2023, 26(26): 3269-3275.
23
刘婷彦,闫钢风,张育才,等. 上海市二级以上公立医院儿科急诊现状调查[J]. 中国小儿急救医学2022, 29(1): 33-39.
24
李娜,黄烈雨,陈浩,等. 德国疾控体系信息化建设现状及对中国的启示[J]. 中国预防医学杂志2024, 25(1): 123-128.
25
王思思,尤芝娜,蒋烨琛,等. 基层医师儿科诊疗三阶段标准化培养模式的探索[J]. 中华医学教育探索杂志2023, 22(9): 1304-1307.
26
Chee E, Huang K, Haggie S, et al. Systematic review of clinical practice guidelines on the management of community acquired pneumonia in children[J]. Paediatr Respir Rev, 2022, 42: 59-68.
27
Kim JM, Kim JA, Rhee JE, et al. Genomic surveillance for community-acquired pneumonia of unknown etiology in children[J]. Int J Infect Dis, 2025, 161: 108093.
28
胡海贇,惠舟奇,王春,等. 39 025例上海儿童呼吸道病原体感染及流行病学特征分析[J/OL]. 中华肺部疾病杂志(电子版), 2026, 19(1): 117-123.
29
Chen R, Li Z, Li D, et al. Clinical utility of bronchoalveolar lavage fluid metagenomic next-generation sequencing in the etiological diagnosis of community-acquired pneumonia in children[J]. Int J Med Microbiol, 2026, 322: 151701.
30
中华医学会儿科学分会呼吸学组,中华儿科杂志编辑委员会,中国医药教育协会儿科专业委员会,等. 儿童社区获得性肺炎管理指南(2024修订)[J]. 中华儿科杂志2024, 62(10): 920- 930.
31
刘舒嫣,姚弥,张家玮,等. 北京市与深圳市儿童分级诊疗相关政策对比分析[J]. 中国全科医学2024, 27(13): 1550-1555.
32
殷涛,王晰,尹德卢. 社区卫生服务中心常用儿科医疗设备和药品配备及使用情况分析[J]. 中华医院管理杂志2023, 39(1): 27-31.
33
Zuo Y, Peng H, Hu P, et al. Association between adjunctive corticosteroid therapy and clinical outcomes in children with severe viral community-acquired pneumonia: A retrospective cohort study[J]. Medicine (Baltimore), 2026, 105(5): e47498.
34
叶颖子,桂永浩,陆权,等. 上海市社区获得性肺炎住院患儿的医疗费用分析[J]. 中华儿科杂志2023, 61(2): 146-153.
35
Francavilla M, Scarlato L, Camporesi A, et al. Lung ultrasound for the diagnosis and monitoring of community-acquired pneumonia in children: a prospective observational study[J]. Front Pediatr, 2025, 13: 1702388.
36
Benkendorff A, Puntscher S, Flatscher-Thöni M, et al. Shorter versus longer antibiotic treatment in children with community-acquired pneumonia: A systematic review with Meta-analyses[J]. Dtsch Arztebl Int, 2026, (Forthcoming):arztebl.m2025.0238.
[1] 罗旭芳, 王艳子, 滕红娜, 赵德莉, 袁丽, 靳思雨, 官浩. 基于时机理论对重度烧伤患儿照护者照护体验的质性研究[J/OL]. 中华损伤与修复杂志(电子版), 2026, 21(01): 40-46.
[2] 王闪, 张忠威, 邓莉平, 熊勇, 高世成, 梁科, 张永喜, 马智勇. 发热伴血小板减少综合征与恙虫病临床特征对比分析:基于单中心真实世界的诊疗启示[J/OL]. 中华实验和临床感染病杂志(电子版), 2026, 20(01): 15-21.
[3] 戚红霞, 张李娜, 王璐璐, 黄夕夏, 刘锋华. 胃息肉合并结肠息肉患者临床特征及其与不同亚型幽门螺杆菌感染的关系[J/OL]. 中华实验和临床感染病杂志(电子版), 2026, 20(01): 54-64.
[4] 王妮, 赵哲, 王敏, 缪怡. 瑞马唑仑联合右美托咪定滴鼻在小儿腹腔镜疝囊高位结扎术中的应用[J/OL]. 中华疝和腹壁外科杂志(电子版), 2026, 20(02): 190-194.
[5] 杜东莲, 史志伟, 姚洁, 张树敏, 代卫斌. 基于CT影像组学和临床特征预测单发肺结节生长的临床意义[J/OL]. 中华肺部疾病杂志(电子版), 2026, 19(01): 56-61.
[6] 郑文灏, 申锦龙, 张红军, 顾兴. 205例非结核分枝杆菌肺病的性别特征性分析[J/OL]. 中华肺部疾病杂志(电子版), 2026, 19(01): 100-105.
[7] 胡海贇, 惠舟奇, 王春, 张婷, 李晓露, 李丹, 张玲玲, 沈爱珠, 张静佳, 高欢欢. 39 025例上海儿童呼吸道病原体感染及流行病学特征分析[J/OL]. 中华肺部疾病杂志(电子版), 2026, 19(01): 117-123.
[8] 叶玉娇, 李雅雯, 陈茂娴, 唐甜甜, 黄金钰, 邱秀燕. 腹部结核并发肺部感染21例临床特征分析[J/OL]. 中华肺部疾病杂志(电子版), 2026, 19(01): 164-167.
[9] 麦吾兰江·麦麦提, 阿力娅·图拉丁, 吐尔洪江·吐逊. ABO血型不相容肝移植免疫抑制策略[J/OL]. 中华肝脏外科手术学电子杂志, 2026, 15(02): 152-159.
[10] 杨宁, 张立翱, 李仁君, 金水. 非遗传性结直肠息肉病患者的临床特征及息肉复发的影响因素分析[J/OL]. 中华结直肠疾病电子杂志, 2026, 15(02): 168-174.
[11] 陈赛文, 吴青杰, 林昱东, 张思成. 超声引导下闭合复位克氏针固定与切开复位克氏针固定治疗儿童肱骨内上髁骨折的疗效比较[J/OL]. 中华肩肘外科电子杂志, 2026, 14(01): 38-44.
[12] 许萍萍, 宋丹阳, 李笑, 李辉, 王霞. 降钙素原与氨基末端B型利钠肽原联合评分对甲泼尼龙联合集成化血液净化治疗儿童严重脓毒症效果的分层价值[J/OL]. 中华肾病研究电子杂志, 2026, 15(02): 93-99.
[13] 王辉, 孙咏琪. 儿童遗传性肾脏病再认识[J/OL]. 中华肾病研究电子杂志, 2026, 15(01): 8-14.
[14] 赵文龙, 刘冬, 达娜, 古力米热, 张经, 木拉地力, 吉文玉. 多模态技术在儿童脑功能区肿瘤切除术中的应用进展[J/OL]. 中华神经创伤外科电子杂志, 2026, 12(01): 45-51.
[15] 汪嘉曦, 叶曾盼盼, 冉茂兵, 刘文科. 儿童颅内巨大脑膜瘤一例报道[J/OL]. 中华神经创伤外科电子杂志, 2026, 12(01): 57-59.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?