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中华肺部疾病杂志(电子版) ›› 2026, Vol. 19 ›› Issue (04) : 701 -704. doi: 10.3877/cma.j.issn.1674-6902.2026.04.027

综述

慢性阻塞性肺疾病合并肝纤维化的研究进展
凌煜滢, 杜丽()   
  1. 430071 武汉,武汉大学中南医院肝胆胰外科
  • 收稿日期:2026-03-25 出版日期:2026-08-25
  • 通信作者: 杜丽
  • 基金资助:
    武汉市护理学会2024年度青年项目(WHHL202421)

Research progress on chronic obstructive pulmonary disease complicated with hepatic fibrosis

Yuying Ling, Li Du()   

  • Received:2026-03-25 Published:2026-08-25
  • Corresponding author: Li Du
引用本文:

凌煜滢, 杜丽. 慢性阻塞性肺疾病合并肝纤维化的研究进展[J/OL]. 中华肺部疾病杂志(电子版), 2026, 19(04): 701-704.

Yuying Ling, Li Du. Research progress on chronic obstructive pulmonary disease complicated with hepatic fibrosis[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2026, 19(04): 701-704.

慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)是一种以持续性气流受限为特征的常见慢性呼吸系统疾病,已成为全球第三大死亡原因,疾病负担沉重。近年来,COPD的合并症问题备受关注,其中肝纤维化作为重要的代谢性合并症逐渐进入研究视野。COPD合并肝纤维化的共病情况和对患者预后的潜在影响日益受到重视。COPD与肝纤维化之间存在共同的病理生理基础。系统性慢性炎症是两者共病的核心驱动因素。COPD患者中肝脏代谢异常的发生率显著高于普通人群,合并肝硬化可明显增加COPD患者的住院死亡风险。两者通过系统性炎症网络相互影响,涉及多条关键信号通路的异常激活。COPD患者因长期低氧血症,肝脏作为高耗氧器官易受缺血缺氧损伤肝功能异常可影响COPD药物代谢,加重低氧血症,增加急性加重风险和感染易感性。治疗管理方面,COPD合并肝纤维化患者需兼顾肺部与肝脏疾病特点进行个体化调整。未来研究应聚焦于共病机制的分子水平探索、早期生物标志物筛查和个体化治疗研究,为临床实践提供理论依据,为COPD合并肝纤维化患者提供精准有效的管理策略。

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