Abstract:
Objective Study the recovery of the meropenem micro dialysis probe in normal rats and in rats of sepsis in vivo.
Method Rats randomly divided into two groups: control group(1case)and sepsis group (3 cases). firstly, to probe into the rat skin, muscle, blood vessels and lungs, respectively, then, collect samples, and then, determination of different parts of the recovery.
Result The recovery of all research target parts ( lungs, blood vessels, skin and muscles ), the normal rats were 30.14%±7.62%, 26.20%±0.14%, 25.90%±1.28%, 13.95%±0.32%. And the sepsis group were 46.43%±1.50%, 45.96%±1.78%, 33.93%±0.39%, 39.48%±2.38%. The recovery in control group were lower than target parts of the rats of sepsis group, the recovery both in control group and sepsis group at the target of the study area are highest in lung.
Conclusion Meropenem was a high protein binding rate of drug, the lung protein content was low, but the pulmonary absorption of meropenem was the least, so meropenem in the lung had the highest recovery rate. By micro dialysis technology research normal and sepsis in rats of different target parts of a recovery, and then calculate different drug concentration of the target area.
Key words:
Meropenem,
Microdialysis,
Sepsis rats,
Recovery
Songxi Guo, Ying Wang, Chunsheng Liu, Jingchao Zhou, Suiyang Zhang, Dan Wang. Recovery of the meropenem micro dialysis probe in normal rats and in rats of sepsis in vivo[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2017, 10(04): 420-422.