To investigate the effect of acid suppressive drugs on pulmonary infection and acute gastric mucosal lesion in patients with acute cerebral infarction.

A retrospective analysis 350 cases from July 2010 to December 2015 in the Department of Neurology of our hospital, which diagnosed acute cerebral infarction patients, older than 18 years, were examined by MR examination of posterior circulation acute cerebral infarction. All the patients were admitted within 48 hours of onset, and before admission, no fever, sputum and other symptoms of pulmonary infection, obviously no increase or decrease of white blood cell, lung imaging and no new changes, and no clinical manifestations of acute gastric mucosal lesions after admission. According to whether the preventive use of proton pump inhibitors of acid inhibitory drugs, which were divided into the use of acid suppressive medication group and non use of acid suppressive drug group. The sex, age, diabetes the history of coronary heart disease, disorder of consciousness, dysphagia, lung disease, hypertension, history of chronic disease were balanced, analysis of whether the use of acid suppressive drugs on acute cerebral infarction, the incidence of pulmonary infection and acute gastric mucosal lesions. The data were statistically analyzed to evaluate the effect of acid suppression drugs on patients with acute cerebral infarction.

The mean age of the 350 patients was 72.3 years, male 210 cases accounted for 60%, female 140 cases accounted for 40%. There were 92 male and 68 female patients in the anti acid group, accounting for 45.7%, with an average age of 73.5 years. There were 118 males and 72 females in non acid drug group, accounting for 54.3%, with an average age of 71.2 years. 94 cases had pulmonary infection, and the total infection rate was 26.8% in all of the 350 patients; Male 67 cases accounted for 71.3%, Female 27 cases accounted for 28.7%; There were 56 cases of pulmonary infection in acid suppressive group, the infection rate was 35%, 38 cases of lung infection in the non acid drug group, the infection rate was 20%; The incidence of pulmonary infection between the two groups was statistically significant. There were 63 cases of pulmonary infection in patients with consciousness disorder, accounting for 66.3%. 28 patients with dysphagia had pulmonary infection, accounting for about 44.5%. There were 81 cases of acute gastric mucosal lesions, the incidence of which was about 23.1%, of which there were acid suppression group (n=29) and non acid suppression group (n=52). There was statistical significance between the two groups. A total of 53 patients had a history of chronic gastric diseases, among which, there were 25 cases of anti acid drugs, and 5 cases of acute gastric mucosal lesions occurred; There were 28 cases of non acid drug group, and 13 cases of acute gastric mucosal lesions; The difference was statistically significant.

The use of acid suppressive drugs will obviously increase after the cycle of pulmonary infection in acute cerebral infarction patients with acute gastric mucosal lesions, acid suppression drug group was lower than the control group. The patients were evaluated by the risk stratification, and then the best results were obtained by the use of acid suppressing drugs.