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Chinese Journal of Lung Diseases(Electronic Edition) ›› 2017, Vol. 10 ›› Issue (04): 450-456. doi: 10.3877/cma.j.issn.1674-6902.2017.03.018

Special Issue:

• Original Article • Previous Articles     Next Articles

System evalution on effectiveness of EGFR-TKIs compared with chemotherapy in treatment of clinical-selected non-small-cell lung carcinoma

Chunqin Tian1,(), Xinhan Zhao2, Huisheng Geng3, Lichun Cui4, Xuan Wang4, Jianfei Du4   

  1. 1. Oncology Department of Xi′an jiaotong university first affiliated hospital, xi an 710061 China; Oncology Department of the International cooperation Chang′an Hospital, Xi′an China 710016
    3. Radiotherapy Centre Department of the International cooperation Chang′an Hospital, xi′an 710016 China
    4. Oncology Department of the International cooperation Chang′an Hospital, Xi′an China 710016
  • Received:2016-06-24 Online:2017-08-20 Published:2017-08-20
  • Contact: Chunqin Tian
  • About author:
    Corresponding author: Tian Chunqin, Email:

Abstract:

Objective

To analyze the effectiveness of epithelial growth factor receptor-TKIs(EGFR-TKIs) compared with chemotherapy on the clinical-selected patients.

Method

Randomized controlled trials(RCT) evaluating the effectiveness of EGFR-TKIs compared with chemotherapy as first line treatment of the clinical-selected NSCLC were obtained from PubMed, the Cochrane library and EMBASE. All literatures were assessed by the inclusion and exclusion criteria, quality assessment and data abstraction. The Meta analysis was performed by RevMan 5.3.5 (Cochrane Collaboration) and STATA 12.0 (STATA Corp, College station, TX) software and was contrasted in EGFR TKIs-treatment of the clinical-selected NSCLC patients curative effect. The stability and reliability were evaluated by sensitivity analysis and publication bias analysis.

Results

A total of 5 trials with 1 719 patients were included in the meta-analysis. The RR, PFS and OS of clinical-selected NSCLC patients treated with EGFR-TKIs alone or EGFR-TKIs in combination with chemotherapy as first-line therapy didn′t significantly increased compared with that of the patients treated with chemotherapy.

Conclusion

EGFR-TKIs therapy as first-line treatment was not suit for clinical-selected NSCLC patients.

Key words: Non-small-cell lung carcinoma, Epidermal growth factor receptor, Chemotherapy, Randomized controlled trial

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