To explore the correlation between the expression of MEIS2 and BRCA1 and the prognosis of non-small-cell lung carcinoma (NSCLC) after operation and chemotherapy.

A total of 61 paraffin-embedded tissue samples were collected from the patients with surgically-resected and pathologically-diagnosed NSCLC (non-small cell lung cancer) in Yichang First People′s Hospital from February 2012 to January 2016. The personal information, clinical information and survival follow-up data of those patients were also collected and analyzed. Immunohistochemical staining was employed to detect the expression levels of MEIS2 and BRCA1, and the correlation between the expression levels of MEIS2 and BRCA1 was analyzed and the two kinds of gene expression were brought into survival analysis. The relationship between MEIS2 and BRCA1 expression and the curative effect of postoperative adjuvant chemotherapy of NSCLC was studied, too.

The patients with NSCLC were treated with platinum-based chemotherapy for 4-6 treatment cycles: effective in 20 patients, with CR+ PR=32.8%, and ineffective in 41 patients, with SD+ PD=67.2%. The effective rate of low expression of BRCA1 was 23.0% (14/61) and high expression of BRCA1 was 9.8% (6/61), and obvious significant difference was found (r=0.59, P=0.003). The effective rate of low expression of MEIS2 expression was 21.3% (13/61) and high expression of MEIS2 was 11.5% (7/61), and obvious significant difference was found (P<0.01).

The immunohistochemical results show that the expression levels of BRCA1 and MEIS2 are significantly positively correlated, and the expression levels of MEIS2 and BRCA1 are correlated with the prognosis of chemotherapy in the patients with NSCLC. The lower the expression levels of BRCA1 and MEIS2 are, the better the chemotherapeutic effect is.