Clinical significance of fractional exhaled nitric oxide in asthma patients

doi:10.3877/cma.j.issn.1674-6902.2020.03.002

Abstract

Abstract:

Objective

Asthma is characterized by chronic airway inflammatory responses, mainly involving the recruitment and activation of eosinophils. Exhaled nitric oxide (FeNO) is a non-invasive marker of airway inflammation. The article aims to explore the clinical role of FeNO in asthma patients.

Methods

We evaluated the FeNO, the pulmonary function parameters and the asthmatic control test (ACT) scores of 94 asthma patients before and after treatment. Among them, 75 patients completed the follow-up visits for one month and 73 patients completed the follow-up visits for three months. We analyzed some related factors of the control level of asthma patients in our hospital.

Results

The percentage of forced expiratory volume in one second (FEV1%) at diagnosis had the most advantage in predicting asthma control, and there was no significant difference in FeNO and pulmonary function parameters of asthma patients according to the ACT scores. There was no significant correlation between FeNO and pulmonary function parameters, ACT scores, IgE and eosinophil count. There was a positive correlation between FEV1% and ACT scores (r=0.04184, P=0.0492). There was a negative correlation between FeNO and ACT scores in the allergic rhinitis (AR) group (r=0.2015, P=0.0128). There was no significant correlation between FeNO and ACT scores after 3 months of treatment.

Conclusion

FeNO before and after treatment can evaluate the therapeutic effect of the patients with asthma, but FeNO cannot predict the control status and the risk of asthma deterioration. FEV1% has more advantages in predicting asthma control.

Key words: Bronchial asthma, Exhaled nitric oxide, Lung functions, Asthmatic control test scores, Clinical significance

Yueyan Lou, Yu Zheng, Liyan Zhang, Feng Zhu, Xueling Wu. Clinical significance of fractional exhaled nitric oxide in asthma patients[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2020, 13(03): 297-301.

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Figures/Tables 7

References 30

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变　量	AUC	P值	95%CI
FeNO	0.474	0.695	0.337～0.611
FEV1%	0.609	0.098	0.479～0.739
MEF25%+MEF50%	0.598	0.138	0.473～0.724
FeNO+FEV1%	0.596	0.145	0.466～0.726
FeNO+FEV1%+MEF25%+MEF50%	0.602	0.123	0.477～0.727
FEV1%+MEF25%+MEF50%	0.594	0.156	0.468～0.720
FeNO+MEF25%+MEF50%	0.606	0.108	0.482～0.730

变　量	AUC	P值	95%CI
FeNO	0.474	0.695	0.337～0.611
FEV1%	0.609	0.098	0.479～0.739
MEF25%+MEF50%	0.598	0.138	0.473～0.724
FeNO+FEV1%	0.596	0.145	0.466～0.726
FeNO+FEV1%+MEF25%+MEF50%	0.602	0.123	0.477～0.727
FEV1%+MEF25%+MEF50%	0.594	0.156	0.468～0.720
FeNO+MEF25%+MEF50%	0.606	0.108	0.482～0.730

组　别		例数	FeNO	FEV1%	FEV₁/FVC%	MEF25%	MEF50%
未控制组ACT		58	64.95±52.20	88.46±21.27	75.16±14.79	64.17±36.89	70.35±29.24
控制组ACT		36	65.94±52.59	93.69±18.70	78.37±13.18	78.01±42.75	79.35±24.22
	P值		0.9332	0.2330	0.2952	0.1025	0.1253

组　别		例数	FeNO	FEV1%	FEV₁/FVC%	MEF25%	MEF50%
未控制组ACT		58	64.95±52.20	88.46±21.27	75.16±14.79	64.17±36.89	70.35±29.24
控制组ACT		36	65.94±52.59	93.69±18.70	78.37±13.18	78.01±42.75	79.35±24.22
	P值		0.9332	0.2330	0.2952	0.1025	0.1253

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