Effectiveness of remote monitoring and adjusting non-invasive ventilator to improve the symptoms of COPD patients with type Ⅱ respiratory failure

doi:10.3877/cma.j.issn.1674-6902.2020.05.007

Abstract

Abstract:

Objective

To evaluate the effect of remote monitoring and adjusting non-invasive ventilator to improve the symptoms of chronic obstructive pulmonary disease(COPD)patients with type Ⅱ respiratory failure.

Method

All of 70 cases COPD patient with type Ⅱ respiratory failure recruit for this trial and final 60 subjects enrolled in this study. These subjects randomly allocated (1︰1) in the observation group and control group by the random number method. The subjects in the observation group received remote monitoring and adjusting non-invasive ventilator, and the control group received continuous low flow oxygen inhalation. Furthermore, all subjects received COPD therapy. The two groups of subjects were followed up for 1 year and vital signs, arterial blood gas analysis, serum inflammatory factors, quality of life score, and the number of acute exacerbations had been evaluated.

Results

The CAT score, mMRC score, 6 MWD improved after subjects received remote monitoring and adjusting non-invasive ventilator therapy, compared to the control group (P<0.05). Moreover, the level of SaO₂, PaO₂, PCT, IL-6, IL-8 and TNF-α decreased in the observation group, compared to the control group (P<0.05).

Conclusion

Remote monitoring and adjusting non-invasive ventilator effectively improved the symptoms of COPD patients with type Ⅱ respiratory failure, promoted pulmonary rehabilitation of COPD patients.

Key words: Chronic obstructive pulmonary disease, Remote monitoring and adjusting non-invasive ventilator, Clinical efficacy

Chunyan Li, Binfeng He, Dan Wang, Zhixin Gan, Chaowang Huang, Yuding Jiao, Mingdong Hu, Jiancheng Xu. Effectiveness of remote monitoring and adjusting non-invasive ventilator to improve the symptoms of COPD patients with type Ⅱ respiratory failure[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2020, 13(05): 612-617.

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Figures/Tables 6

References 25

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临床资料		观察组(n＝30)	对照组(n＝30)	P值
年龄(岁)		67.47±9.56	67.8±8.92	0.83
性别[男(%)]		63.33(19)	60.00%(18)	0.79
	[女(%)]	36.67(11)	40.00(12)	0.80
RR(次/min)		21.47±1.41	21.3±1.84	0.70
HR(次/min)		84.87±5.27	83.53±5.44	0.34
pH		7.37±0.04	7.38±0.03	0.44
PaO₂(mmHg)		69.25±10.72	66.40±7.59	0.24
PaCO₂(mmHg)		59.33±5.06	59.20±5.91	0.93
SaO₂ (%)		85.39±3.75	85.30±3.04	0.92
PCT(ng/L)		1.39±0.25	1.38±0.31	0.91
CRP(ng/L)		24.23±5.33	24.19±3.76	0.97
IL-6(pg/ml)		28.43±5.04	28.40±5.92	0.98
IL-8(pg/ml)		123.10±10.85	122.93±14.46	0.96
TNF-α(pg/ml)		29.67±5.01	30.23±5.04	0.66
6MWD(m)		298.67±81.56	298.63±75.14	1.00
CAT评分		34.63±2.33	34.23±2.49	0.52
mMRC评分		3.40±0.72	3.33±0.88	0.75
BNP(μg/L)		381.87±76.48	381.90±85.45	1.00
年累计住院次数(次/年)		4.47±0.73	4.13±0.82	0.10

临床资料		观察组(n＝30)	对照组(n＝30)	P值
年龄(岁)		67.47±9.56	67.8±8.92	0.83
性别[男(%)]		63.33(19)	60.00%(18)	0.79
	[女(%)]	36.67(11)	40.00(12)	0.80
RR(次/min)		21.47±1.41	21.3±1.84	0.70
HR(次/min)		84.87±5.27	83.53±5.44	0.34
pH		7.37±0.04	7.38±0.03	0.44
PaO₂(mmHg)		69.25±10.72	66.40±7.59	0.24
PaCO₂(mmHg)		59.33±5.06	59.20±5.91	0.93
SaO₂ (%)		85.39±3.75	85.30±3.04	0.92
PCT(ng/L)		1.39±0.25	1.38±0.31	0.91
CRP(ng/L)		24.23±5.33	24.19±3.76	0.97
IL-6(pg/ml)		28.43±5.04	28.40±5.92	0.98
IL-8(pg/ml)		123.10±10.85	122.93±14.46	0.96
TNF-α(pg/ml)		29.67±5.01	30.23±5.04	0.66
6MWD(m)		298.67±81.56	298.63±75.14	1.00
CAT评分		34.63±2.33	34.23±2.49	0.52
mMRC评分		3.40±0.72	3.33±0.88	0.75
BNP(μg/L)		381.87±76.48	381.90±85.45	1.00
年累计住院次数(次/年)		4.47±0.73	4.13±0.82	0.10

组　别	时间	PCT (ng/L)	CRP (mg/L)	IL-6 (pg/ml)	IL-8 (pg/ml)	TNF-α (pg/ml)
观察组	1月	1.39±0.25	24.23±5.33	28.43±5.04	123.10±10.85	29.67±5.01
	12月	0.17±0.06^ab	5.48±0.97^ab	6.80±1.59^ab	41.77±7.15^ab	10.62±1.48^ab
对照组	1月	1.38±0.31	24.19±3.76	28.40±5.92	122.93±14.46	30.23±5.04
	12月	0.75±0.15^a	10.85±1.85^a	15.12±1.88^a	85.73±12.00^a	15.60±2.33^a

组　别	时间	PCT (ng/L)	CRP (mg/L)	IL-6 (pg/ml)	IL-8 (pg/ml)	TNF-α (pg/ml)
观察组	1月	1.39±0.25	24.23±5.33	28.43±5.04	123.10±10.85	29.67±5.01
	12月	0.17±0.06^ab	5.48±0.97^ab	6.80±1.59^ab	41.77±7.15^ab	10.62±1.48^ab
对照组	1月	1.38±0.31	24.19±3.76	28.40±5.92	122.93±14.46	30.23±5.04
	12月	0.75±0.15^a	10.85±1.85^a	15.12±1.88^a	85.73±12.00^a	15.60±2.33^a

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