To investigate the effects of doxofylline on intraoperative pulmonary protection and its mechanism in patients undergoing double lumen endotracheal intubation for one-lung ventilation.

120 patients given pulmonary lobotomy were divided into two groups, 62 cases in study group, 58 cases in control group. Two groups underwent general anesthesia using double lumen endotracheal intubation for one-lung ventilation, the study group were used doxofylline injection for intervention, while the control group were used equal volume of normal saline for intervention. All patients of respiratory dynamics index (compliance of lung, resistance airway, pressure of platform, pressure of peak), blood gas analysis indexes (PaO₂, PaCO₂) and oxidative stress indicators (MDA, SOD), inflammation index (TNF-α, IL-6, IL-10) were detected immediately before administration (T1), at 30 min (T2), 60 min (T3) after one-lung ventilation, the difference of postoperative pulmonary complications between the two groups were compared.

At T1, there were no significant differences in respiratory dynamics, blood gas analysis, oxidative stress and inflammation indexes between the two groups (P>0.05), which were comparable. At T2~T3, compliance of lung, PaO₂ and SOD in the two groups were significantly lower than T1, and resistance of airway, pressure of platform, pressure of peak, PaCO₂, MDA, IL-6, IL-10 and TNF-α were significantly higher than T1, P<0.05.At T2~T3, compliance of lung, PaO₂, SOD, and IL-10 in the study group were significantly higher than those in the control group, and resistance of airway, pressure of platform, pressure of peak, PaCO₂, MDA, IL-6, and TNF-α were significantly lower than those in the control group (P<0.05). The incidence of pulmonary complications in the study group was significantly lower than that in the control group, P<0.05.

Doxofylline can significantly improve pulmonary oxygenation function, reduce the risk of pulmonary complications, thus play an important role on intraoperative pulmonary protection in patients undergoing double lumen endotracheal intubation for one-lung ventilation. The mechanism may be closely related to doxofylline′s anti-oxidative stress, anti-inflammatory, bronchiectasis and ventilation improvement.