To study the Effects of ultrasound guidance combined with general anesthesia on serum NGF-β and MBP in elderly patients with lung lobectomy and postoperative outcome.

A total of 65 elderly patients with lung cancer from February 2020 to March 2021 were selected and randomly divided into observation group 35 cases and control group 30 cases. The observation group was treated with ultrasound guided combination, and the control group was treated with general anesthesia. The operative conditions of the two groups were compared, including intraoperative mean arterial pressure, heart rate, early postoperative vital capacity, postoperative analgesia, preoperative and postoperative changes in NGF-β and MBP levels, early postoperative recovery quality, incidence of postoperative cognitive dysfunction, and incidence of postoperative adverse reactions.

There were no significant differences in operation time, anesthesia time, recovery time and hospital stay between the two groups (P>0.05). The intubation, skin cutting and extubation in observation group were significantly lower than those in control group (P<0.05). The early lung capacity of the observation group was significantly higher than that of the control group at 12 h, 24 h and 48 h after surgery (P<0.05). The postoperative analgesic recovery rate, The Times of analgesic pump pressing, the total amount of infusion, the visual analogue scale (VAS) at 6 h and 12 h after operation in the observation group were significantly lower than those in the control group (P<0.05). The level of NGF-β in observation group was significantly lower than that in control group, and the level of MBP was significantly higher than that in control group (P<0.05). The score of postoperative recovery quality scale (qor-40) in the observation group was significantly higher than that in the control group at 12 h, 48 h and 72 h postoperatively (P<0.05). The incidence of cognitive impairment in the observation group was significantly lower than that in the control group at 6 h, 12 h and 24 h after surgery (P<0.05). The total incidence of adverse reactions in observation group was significantly lower than that in control group (P<0.05).

Ultrasound guidance combined with general anesthesia can effectively improve the levels of serum NGF-β and MBP in elderly patients with lung lobectomy, improve the analgesic effect and promote the early postoperative outcome.