Expression and clinical significance of miR182 and miR126 in peripheral blood of community acquired pneumonia

doi:10.3877/cma.j.issn.1674-6902.2022.02.012

Abstract

Dan Xu, Ming Yin, Miao Yu. Expression and clinical significance of miR182 and miR126 in peripheral blood of community acquired pneumonia[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2022, 15(02): 197-199.

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临床资料		预后良好者(n＝47)	预后不佳者(n＝11)	χ²/t	P值
性别(男/女)		34/13	7/4	0.353	0.553
年龄(岁)				4.673	0.031
	18~65	28	3
	>65	19	8
平均BMI(kg/m²)				0.201	0.654
	19.0~24.0	19	5
	>24.0	28	6
基础疾病
	高血压	7	3	0.737	0.391
	糖尿病	4	1	0.207	0.649
	饮酒史	13	5	2.248	0.134
吸烟史		17	6	2.846	0.092
家族史		7	3	0.002	0.964
机械通气(是/否)		23/24	8/3	2.452	0.117
PSI评分				6.326	0.012
	≥120	15	7
	<120	32	4
Scr(μmol/L)		76.43±16.05	82.57±17.91	1.360	0.178
WBC计数(×10⁹/L)		12.17±2.19	13.72±2.51	2.591	0.011

临床资料		预后良好者(n＝47)	预后不佳者(n＝11)	χ²/t	P值
性别(男/女)		34/13	7/4	0.353	0.553
年龄(岁)				4.673	0.031
	18~65	28	3
	>65	19	8
平均BMI(kg/m²)				0.201	0.654
	19.0~24.0	19	5
	>24.0	28	6
基础疾病
	高血压	7	3	0.737	0.391
	糖尿病	4	1	0.207	0.649
	饮酒史	13	5	2.248	0.134
吸烟史		17	6	2.846	0.092
家族史		7	3	0.002	0.964
机械通气(是/否)		23/24	8/3	2.452	0.117
PSI评分				6.326	0.012
	≥120	15	7
	<120	32	4
Scr(μmol/L)		76.43±16.05	82.57±17.91	1.360	0.178
WBC计数(×10⁹/L)		12.17±2.19	13.72±2.51	2.591	0.011

因　素	β	SE	Wald	P值	OR	95%CI
年龄>65~79岁	1.126	0.743	2.297	0.001	3.083	1.012~9.395
PSI评分≥120分	1.205	0.693	3.023	0.001	3.337	1.095~10.168
WBC计数	1.331	0.719	3.427	0.001	3.785	1.242~11.533

因　素	β	SE	Wald	P值	OR	95%CI
年龄>65~79岁	1.126	0.743	2.297	0.001	3.083	1.012~9.395
PSI评分≥120分	1.205	0.693	3.023	0.001	3.337	1.095~10.168
WBC计数	1.331	0.719	3.427	0.001	3.785	1.242~11.533

指　标	最佳截断点	灵敏度(%)	特异度(%)	AUC	95%CI
miR-182	1.19	70.58	68.85	0.742	0.632~0.851
miR-126	2.01	64.71	70.49	0.724	0.608~0.839
miR-182联合miR-126	-	82.35	72.13	0.833	0.731~0.936

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