To establish the model of severe primary lung blast injury in goats at an altitude of 4600 meters , and to provide experimental basis for the study of the characteristics and pre-hospital treatment of severe primary lung blast injury at high altitude.

Twenty-eight healthy goats were randomly divided into two groups , 3 m group (n=22) and 3.5 m group (n=6). The lungs of goats were injured under the same environmental conditions with 8 kg TNT equivalent new explosives. The vital signs, troponin I, gross anatomy of lung, lung tissue weight and wet / dry specific gravity were observed before injury and 1 h, 24 h after injury. The seriously injured goats were treated with pre-hospital ABC.

12 goats died within 15 minutes (including 15 minutes)after injury, survived more than 15 minutes after injury, but 4 goats died within 30 minutes (including 30 minutes), and the other 12 goats survived. According to the observation of the characteristics of severe primary lung blast injury, persistent respiratory distress, deep malaise, shivering, mouth, eye and nose bleeding, cough, hiccup and unstable standing appeared immediately after injury. The gross anatomy of the lungs of the two groups showed different degrees of pulmonary hemorrhage, pulmonary edema, pleural hemorrhage, pulmonary vesicles and pink foamed sputum in the airway, which were severe blast injury. The AIS score was 4.83 ±0.87. blood clots and a large amount of chyme could be seen in the main bronchus and branch trachea in part of the lungs. The lung injury of severe primary lung blast injury at high altitude is serious, and the on-site environment at high altitude is bad and complex, so it is difficult to treat the routine pre-hospital airway management and respiratory function maintenance program.

The model of severe primary lung blast injury in goats at high altitude can be established by 8 kg TNT equivalent explosive at a distance of 3m and 3.5m. This model is stable and can be used to study the mechanism and pre-hospital treatment of primary lung blast injury at high altitude.