Explore the effects of medication compliance on anxiety, depression and quality of life in patients with chronic obstructive pulmonary disease (COPD) and establish a structural equation model, so as to provide an intervention basis for improving the quality of life in patients with COPD.

From February 2018 to October 2020, 300 patients with chronic obstructive pulmonary disease in the Second Affiliated Hospital of Army Medical University were selected as the research objects. Hospital Anxiety and Depression Scale (HADS), chronic obstructive pulmonary Disease Assessment (CAT) and Morisky Medication Adherence Scale (MMAS-4) were used to evaluate patients with chronic obstructive pulmonary disease, and structural equation modeling software AMOS 24.0 was used for analysis.

In 300 COPD patients, 115 cases(38.33%) were anxious, 110 cases (36.67%) were depressed, and 87 cases (29.00%) were both anxious and depressed. The model data fit results, χ²/df=1.011<3, GFI=0.938>0.9, AGFI=0.924>0.9, CFI=0.999>0.9, NFI=0.931>0.9, IFI=0.999>0.9, RMSER=0.006<0.1, anxiety and depression were the influencing factors of quality of life, the total effect was 0.338, 0.255, respectively. Patient medication compliance is a mediating variable between anxiety and depression and CAT score.

Anxiety and depression, medication adherence and quality of life are closely related in COPD patients. Medication adherence plays a mediating role in the influence of anxiety and depression on CAT score. The negative emotions of anxiety and depression in patients with chronic obstructive pulmonary disease directly or indirectly affect their medication compliance and quality of life. It is suggested that attention should be paid to the evaluation of patients′negative emotions and timely carry out targeted psychological intervention measures.