Correlation of serum CRP, BNP, PCT between sepsis and acute lung injury

doi:10.3877/cma.j.issn.1674-6902.2023.06.004

Abstract

Abstract:

Objective

To analyze the correlation of serum C-reactive protein (CRP), B-type brain natriuretic peptide (BNP) and procalcitonin (PCT) between acute lung injury(ALI) and sepsis.

Methods

All of 53 patients with sepsis admitted to our hospital from January 2019 to December 2022 were selected as the subjects, including 32 patients with concurrent lung injury and 21 patients without concurrent lung injury. Patients with lung injury were divided into low-risk group 15 cases and high-risk group 17 cases according to acute physiology and chronic health status (APACHE Ⅱ) scoring criteria, and were divided into good prognosis 26 cases and poor prognosis 6 cases according to clinical prognosis. The levels of serum CRP, PCT and BNP were determined, and the levels of CRP, BNP, PCT and APACHEⅡ scores of each group were compared. The application value of single detection and combined detection in evaluating the prognosis of sepsis and acute lung injury was analyzed.

Results

CRP (72.98±2.44 vs. 15.58±3.21) μg/ml, PCT (4.18±0.16 vs. 0.41±0.11) ng/ml, BNP (852.68±51.47) levels in patients with lung injury vs. 205.58±45.59) ng/L and APACHE Ⅱ scores (14.98±2.15 vs. 8.66±1.12) were higher than those without lung injury (P<0.05). The levels of CRP (142.65±15.96 vs. 68.21±8.45) μg/ml, PCT (10.09±1.33 vs. 2.08±0.34) ng/ml and BNP (1 425.52±95.44 vs. 796.54±45.59) ng/L were found in high-risk patients and APACHE Ⅱ scores (21.65±3.01 vs. 13.14±1.02) were higher (P<0.05). The levels of CRP (123.65±5.47 vs. 70.58±3.12) μg/ml, PCT (12.18±1.35 vs. 4.69±0.84) ng/ml and BNP (1 329.18±91.41 vs. 709.54±60.58) ng/L were found in patients with poor prognosis and APACHE Ⅱ scores (19.52±3.97 vs. 13.36±3.48) were higher than those of good prognosis (P<0.05). The diagnostic specificity and sensitivity of combined detection for sepsis and acute lung injury were 77.89% and 83.92%, respectively, and the area under the curve (AUC) was 0.859 (95%CI: 0.779~0.935), which was higher than that of single detection.

Conclusion

The severity of acute lung injury and sepsis is detected by serum CRP, BNP and PCT accurately, which has clinical significance for prognosis assessment.

Key words: Sepsis, C-reactive protein, Acute lung injury, Procalcitonin, B type brain natriuretic peptide

Mingxu Shang, Lijuan Wei, Ruochun Shi. Correlation of serum CRP, BNP, PCT between sepsis and acute lung injury[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(06): 766-769.

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References 26

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并发肺损伤	例数	CRP(μg/ml)	PCT(ng/ml)	BNP(ng/L)	APACHE Ⅱ评分(分)
无肺损伤	21	15.58±3.21	0.41±0.11	205.58±45.59	8.66±1.12
肺损伤	32	72.98±2.44	4.18±0.16	852.68±51.47	14.98±2.15
t值		73.850	94.205	46.787	12.385
P值		0.000	0.000	0.000	0.000

并发肺损伤	例数	CRP(μg/ml)	PCT(ng/ml)	BNP(ng/L)	APACHE Ⅱ评分(分)
无肺损伤	21	15.58±3.21	0.41±0.11	205.58±45.59	8.66±1.12
肺损伤	32	72.98±2.44	4.18±0.16	852.68±51.47	14.98±2.15
t值		73.850	94.205	46.787	12.385
P值		0.000	0.000	0.000	0.000

组　别	例数	CRP(μg/ml)	PCT(ng/ml)	BNP(ng/L)	APACHE Ⅱ评分(分)
低危组	15	68.21±8.45	2.08±0.34	796.54±45.59	13.14±1.02
高危组	17	142.65±15.96	10.09±1.33	1 425.52±95.44	21.65±3.01
t值		16.156	22.641	23.258	10.417
P值		0.000	0.000	0.000	0.000

组　别	例数	CRP(μg/ml)	PCT(ng/ml)	BNP(ng/L)	APACHE Ⅱ评分(分)
低危组	15	68.21±8.45	2.08±0.34	796.54±45.59	13.14±1.02
高危组	17	142.65±15.96	10.09±1.33	1 425.52±95.44	21.65±3.01
t值		16.156	22.641	23.258	10.417
P值		0.000	0.000	0.000	0.000

预后情况	例数	CRP(μg/ml)	PCT(ng/ml)	BNP(ng/L)	APACHE Ⅱ评分(分)
预后好	26	70.58±3.12	4.69±0.84	709.54±60.58	13.36±3.48
预后差	6	123.65±5.47	12.18±1.35	1 329.18±91.41	19.52±3.97
t值		32.375	17.512	20.507	3.813
P值		0.000	0.000	0.000	0.002

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