To analyze the expression and clinical significance of soluble human matrix lysate 2 (sST2) in serum of patients with community-acquired pneumonia (CAP).

All of 56 patients with community-acquired pneumonia (CAP) admitted to our hospital from April 2023 to July 2023 were included as the research group, and 41 cases of clinical stability recovery were divided into control group and 15 cases of clinical stability recovery were observed group. The patient′s sST2 level was detected, and the general data such as gender, age and smoking history and clinical data, including white blood cell count (WBC), neutrophil (Neu), lymphocyte (Lym), C-reactive protein (CRP), N- terminal pro-brain natriuretic peptide (NT-proBNP), and so on, were collected by using electronic medical records. Multivariate logistics regression was used to analyze the influencing factors of clinical stability, and the ROC curve was drawn to analyze the predictive value of sST2 level on clinical stability.

The age (59.88±9.20) years old, CRP (53.15±10.24 )mg/ml, PCT(1.20±0.24 )ng/ml, sST2(73.61±8.16)ng/ml, PSI grade Ⅳ~Ⅴ in 10 cases (66.67%) in observation group were higher than those in control group (54.10±9.16 )years old, CRP(12.30±2.16)mg/ml, PCT(0.08±0.02) ng/ml, sST2(64.87±6.25)ng/ml and PSI classification Ⅳ~Ⅴ (P<0.05) in 10 cases (66.67%). Multivariate logistics regression analysis showed that CRP(OR=1.042), PCT(OR=0.682) and sST2(OR=0.848) were the influencing factors for the clinical stability of elderly CAP patients (P<0.05). The ROC curve shows that AUC of sST2 level is 0.815, and 95%CI is 0.688-0.906. The AUC of CRP level was 0.733, and 95%CI was 0.598-0.843. The AUC of PCT level is 0.798, and 95%CI was 0.709-0.870.

The level of sST2 in CAP patients is significantly higher. The level of sST2 at admission can be used as a biomarker to predict the recovery of clinical stability in CAP patients.