To analyze the distribution and drug susceptibility of pathogenic bacteria of hospital acquired pneumonia (HAP) in Tang Du Hospital of Air Force Military Medical University, so as to provide reference for the empirical treatment of HAP.

Bacterial culture results and drug susceptibility results of clinical respiratory specimens were collected retrospectively from January, 2017 to December, 2019 in our hospital.

A total of 5155 qualified strains were collected and screened, Acinetobacter baumannii accounted for the most (26.7%), followed by Pseudomonas aeruginosa (19.6%) and klebsiella pneumoniae (14.4%) and so on. In addition to polycolistin and tegacycline, Acinetobacter baumannii showed high sensitivity to cefoperazone-sulbactan (76.12%), while most antibiotics less than 20%. Among them, the detection rates of multi-drug resistant, extensively drug resistant and carbapenem-resistant Acinetobacter baumannii were 78.49%, 12.28% and 84.81%, respectively. The sensitivity of Pseudomonas aeruginosa to amikacin was high up to 86.26%, and that of imipenem and meropenem was lower, about 60%. the detection rates of multi-drug resistant, extensively drug resistant and carbapenem-resistant Pseudomonas aeruginosa were 34.42%, 3.46% and 38.18%, respectively. The detection rate of carbapenem-resistant Enterobacteriaceae was 11.67%, No strains resistant to vancomycin or linezolid were found in Staphylococcus aureus and Streptococcus pneumoniae. The detection of Methicillin-resistant Staphylococcus aureus were 46.03%.

The situation of drug resistance of HAP pathogens is severe, which should be paid enough attention in clinical practice. Strengthening bacterial drug resistance monitoring can effectively guide clinical rational drug use.