Nip-like protein Xis overexpressed and predicts poor prognosis in non-small cell lung cancer

doi:10.3877/cma.j.issn.1674-6902.2021.04.002

Abstract

Abstract:

Objective

To investigate the expression and clinical significance of Nip-like protein X (NIX/BNIP3L) in non-small cell lung cancer (NSCLC).

Methods

It was collected that tumor and adjacent tissue samples from 68 patients with NSCLC, and conducted immunohistochemistry to detect NIX expression. The correlations between NIX expression and clinicopathologic characteristics and prognosis were evaluated using the SPSS 22.0 software package.

Results

NIX was highly expressed in NSCLC tissue samples. NIX expression was correlated with the degree of NSCLC differentiation and lymph node metastasis(P=0.001, P=0.005), but not with sex, age, pathologic type, distant metastasis, or TNM stage. In addition, multivariate Cox regression analysis showed that NIX protein expression, regional lymph node metastasis, pathological differentiation, and smoking status were independent prognostic factors for NSCLC patients.Based on the differences of NIX expression in NACLC, TheK-M analysis results showed that the upregulation of NIX expression was significantly correlated with the decrease of overall survival rate and progression-free survival rateinNSCLC(P<0.01).

Conclusion

NIX expression is elevated in NSCLC and may contribute to the invasion and metastasis of lung cancer. Upregulation of NIX expression can affect the prognosis of NSCLC patients.NIX may represent a therapeutic target for the treatment of NSCLC.

Key words: Nip-like protein X, Non-small cell lung cancer, Clinicopathologic characteristics, Prognosis

Yu Chen, Yuxiu Wang, Lingfeng Min. Nip-like protein Xis overexpressed and predicts poor prognosis in non-small cell lung cancer[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2021, 14(04): 412-416.

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Figures/Tables 4

References 32

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临床资料		总数	NIX表达		P值
临床资料		总数	低	高	P值
性　别					0.408
	女	19	9	10
	男	49	17	32
年　龄					0.208
	≤60	25	7	18
	>60	43	19	24
病理类型					0.795
	鳞癌	44	16	28
	腺癌	24	10	14
淋巴结浸润					0.001^a
	N0	26	19	7
	N1	11	2	9
	N2	19	2	17
	N3	12	3	9
远处转移					0.136
	M0	53	23	30
	M1	15	3	12
TNM分期					0.060
	Ⅰ	11	5	6
	Ⅱ	22	14	8
	Ⅲ	20	4	16
	Ⅳ	15	3	12
分化状态					0.005^a
	高	21	14	7
	中等	25	7	18
	低	22	5	17

临床资料		总数	NIX表达		P值
临床资料		总数	低	高	P值
性　别					0.408
	女	19	9	10
	男	49	17	32
年　龄					0.208
	≤60	25	7	18
	>60	43	19	24
病理类型					0.795
	鳞癌	44	16	28
	腺癌	24	10	14
淋巴结浸润					0.001^a
	N0	26	19	7
	N1	11	2	9
	N2	19	2	17
	N3	12	3	9
远处转移					0.136
	M0	53	23	30
	M1	15	3	12
TNM分期					0.060
	Ⅰ	11	5	6
	Ⅱ	22	14	8
	Ⅲ	20	4	16
	Ⅳ	15	3	12
分化状态					0.005^a
	高	21	14	7
	中等	25	7	18
	低	22	5	17

临床资料	风险比	95%置信区间	P值
性别	0.486	0.171～1.379	0.175
年龄(年)	1.279	0.487～3.362	0.617
病理类型	1.478	0.496～4.298	0.719
淋巴结	7.901	3.231～16.514	0.008^a
远处转移	1.675	0.987～1.657	0.091
TNM	0.476	0.273～1.564	0.387
分化	6.501	2.302～12.967	0.002^a
NIX表达	2.245	0.873～5.817	0.049^a

临床资料	风险比	95%置信区间	P值
性别	0.486	0.171～1.379	0.175
年龄(年)	1.279	0.487～3.362	0.617
病理类型	1.478	0.496～4.298	0.719
淋巴结	7.901	3.231～16.514	0.008^a
远处转移	1.675	0.987～1.657	0.091
TNM	0.476	0.273～1.564	0.387
分化	6.501	2.302～12.967	0.002^a
NIX表达	2.245	0.873～5.817	0.049^a

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