To analyze the significance of low-dose energy spectrum CT combined with multiplanar reformation (MPR) in the differential diagnosis of lung cancer and pneumonia nodules.

A total of 115 patients admitted to our hospital from February 2021 to February 2023 who were pathologically confirmed and underwent energy spectrum CT and MPR examination were divided into 49 patients with pneumonia nodule group, 31 patients with lung squamous cell carcinoma group and 35 patients with lung adenocarcinoma group according to pathological results. Iodine content, water content and slope K value of standard energy spectrum decay curve of each group were analyzed, and the imaging findings were compared.

Arterial iodine content [(4.51±0.43) vs. (5.74±0.38) vs. (7.09±0.31)]mg/ml and water content[(958.47±130.25)vs. (1 089.36±132.78) vs. (1 102.25±127.28 )]mg/ml in pulmonary nodules, squamous cell carcinoma and adenocarcinoma groups, slope of standardized energy spectrum decay curve [(0.61±0.05) vs. (0.82±0.04) vs. (0.97±0.07)]Iodine content in Kev and Ⅳ stage [(7.36±0.18) vs. (7.80±0.17) vs. (8.59±0.28)] mg/ml gradually increased (P<0.05); Water content in venous stage of pulmonary nodules, squamous cell carcinoma and adenocarcinoma groups [(1 017.46±98.36) vs. (1 045.67±101.28) vs. (1 038.19±97.28)]mg/ml and slope of standard energy spectrum decay curve [(0.59±0.05) vs. (0.60±0.03) vs. (0.61±0.06)] Kev comparison(P>0.05); There were statistically significant differences in the imaging findings of pulmonary nodules and lung squamous carcinoma and lung adenocarcinoma (P<0.05), while there were statistically significant differences in the imaging findings of lung squamous carcinoma and lung adenocarcinoma and pleural depression sign (P<0.05).

The quantitative analysis of low-dose energy spectrum CT combined with MPR is of clinical significance in the differential diagnosis of pulmonary nodules, lung squamous cell carcinoma and lung adenocarcinoma.