Abstract:
Objective
To analyze the correlation between serum soluble growth stimulation expressed gene 2 protein （sST-2） and the risk of pulmonary hypertension complicating acute pulmonary embolism（APE）.
Methods
Seventy-two APE patients treated in our hospital from January 2021 to January 2024 were selected. Sixteen patients with concurrent pulmonary hypertension were assigned to the observation group，and 56 patients without pulmonary hypertension served as the control group. General data，serum sST-2 levels，forced expiratory volume in one second （FEV1），interleukin-6 （IL-6），red cell distribution width （RDW），and mean platelet volume （MPV） were compared between the two groups. Logistic regression was used to analyze influencing factors of pulmonary hypertension in APE patients. The predictive value of these factors for pulmonary hypertension in APE patients was assessed using receiver operating characteristic （ROC） curves.
Results
The FEV1 of the observation group was （52.78±5.33）L，lower than that of the control group （58.25±6.35）L. The serum sST-2 （133.15±8.34）ng/ml，IL-6 （56.83±5.88）mg/ml，RDW（15.64±3.67）%，and D-dimer （3.13±0.77） mg/L of the observation group were higher than those of the control group sST-2 （122.62±5.77）ng/ml，IL-6 （51.57±1.36）mg/ml，RDW （12.72±1.48）%，D-dimer （2.82±0.32）mg/L （P＜0.05）.Logistic regression analysis showed that high serum sST-2 （OR=1.613，95% CI：1.043～2.493），IL-6（OR=3.002，95% CI：1.276～7.060），and RDW （OR=4.029，95% CI：1.135～14.305） were risk factors for acute pulmonary embolism （APE）-related pulmonary hypertension，while FEV1（OR= 0.692，95% CI：0.484 ～0.988） was a protective factor （P＜0.05）. Receiver operating characteristic （ROC） curve results showed that the area under the curve （AUC） of FEV1，serum sST-2，IL-6，and RDW for diagnosing APE-related pulmonary hypertension were 0.733，0.853，0.828，and 0.771，respectively （P＜0.05）.
Conclusion
FEV1，serum sST-2，IL-6，and RDW are influencing factors for pulmonary hypertension complicating APE，and serum sST-2 can predict the occurrence of pulmonary hypertension in APE patients.
Key words:
Acute pulmonary embolism,
Pulmonary hypertension,
D-dimer,
Soluble growth stimulation expressed gene 2 protein,
Forced expiratory volume in one second,
Red cell distribution width
Wendeng Chen, Min Chen, Shuxiang Wu, Xiangzhen Zheng, Bin Chen, Liutong Chen. Clinical research of serum soluble growth stimulation expressed gene 2 and the risk of acute pulmonary embolism complicated with pulmonary hypertension[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2025, 18(03): 401-405.