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中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (03) : 442 -444. doi: 10.3877/cma.j.issn.1674-6902.2023.03.041

病例报告

紫杉醇治疗胸腺鳞癌致大疱性表皮松解坏死性药疹救治成功一例
黄彩英, 陈萍(), 潘杰, 莫彩云, 尚敏红, 周俊   
  1. 400037 重庆,陆军(第三)军医大学第二附属医院肿瘤科
  • 收稿日期:2023-01-07 出版日期:2023-06-25
  • 通信作者: 陈萍

Paclitaxel treatment of thymic squamous cell carcinoma caused by epidermolysis necrotizing drug rash treatment successful case

Caiying Huang, Ping Chen(), Jie Pan   

  • Received:2023-01-07 Published:2023-06-25
  • Corresponding author: Ping Chen
引用本文:

黄彩英, 陈萍, 潘杰, 莫彩云, 尚敏红, 周俊. 紫杉醇治疗胸腺鳞癌致大疱性表皮松解坏死性药疹救治成功一例[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 442-444.

Caiying Huang, Ping Chen, Jie Pan. Paclitaxel treatment of thymic squamous cell carcinoma caused by epidermolysis necrotizing drug rash treatment successful case[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(03): 442-444.

胸腺鳞癌是一种罕见的纵隔恶性上皮肿瘤,为最常见胸腺上皮肿瘤类型,胸腺鳞癌个体化诊疗方案选择无明确标准[1,2]。注射用紫杉醇(白蛋白结合型)是第三代紫杉类化疗药,为一种抗微管药物,能诱导和促进微管装配,具有聚合和稳定微管作用,干扰微管再排列,停止有丝分裂,抑制肿瘤细胞生长[3]。紫杉醇不良反应多有报道[4,5,6,7]。为保证用药安全,提高胸腺鳞癌诊疗水平,本文对我院收治的紫杉醇治疗胸腺鳞癌诱发严重大疱性表皮松解坏死性药疹1例进行分析,报告如下。

图1 患者病理图片
图2 病理图片;注:A:躯干红斑破溃;B:右前臂掌侧水泡破溃
图3 病理图片;注:A:治疗后躯干皮肤情况;B:治疗后右前臂掌侧皮肤情况
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