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中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (03) : 445 -447. doi: 10.3877/cma.j.issn.1674-6902.2023.03.042

病例报告

以肺磨玻璃结节为表现的肺转移性恶性黑色素瘤一例
余枝娟, 杨美, 张建勇()   
  1. 563000 遵义,遵义医科大学附属医院呼吸与危重症医学科呼吸二病区
  • 收稿日期:2023-01-14 出版日期:2023-06-25
  • 通信作者: 张建勇

One case report of pulmonary metastatic malignant melanoma presenting by pulmonary ground glass nodules

Zhijuan Yu, Mei Yang, Jianyong Zhang()   

  • Received:2023-01-14 Published:2023-06-25
  • Corresponding author: Jianyong Zhang
引用本文:

余枝娟, 杨美, 张建勇. 以肺磨玻璃结节为表现的肺转移性恶性黑色素瘤一例[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 445-447.

Zhijuan Yu, Mei Yang, Jianyong Zhang. One case report of pulmonary metastatic malignant melanoma presenting by pulmonary ground glass nodules[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(03): 445-447.

恶性黑色素瘤(malignant melanoma, MM)是一类起源于神经嵴黑色素细胞的高度恶性肿瘤,仅占所有恶性肿瘤的1%~2%[1,2,3,4]。约5%的MM患者随访期间发生肺转移,肺转移性肿瘤多表现为边界清楚、少有空洞的实性结节,以病变边缘见晕征的磨玻璃结节为表现者罕见[5,6]。本文对我院收治的1例经组织病理确诊的以病变边缘见晕征为特点的肺转移性MM病例进行分析,报告如下。

图1 右足底组织病理。注:2018年7月24日 右足底活检组织HE染色见呈梭形、卵圆形弥漫片状排列的细胞,胞浆内可见黑色素颗粒,异型性明显,可见核分裂像,免疫组化示肿瘤表达:HMB-45(++)、S100(++)、Melan-A(+)、P53(+) 、cydinD(+)、Ki-67(50%+) 低倍染色
图2 患者胸部CT
图3 患者右肺组织病理。注:胸腔镜手术切除右肺组织HE染色可见大量含色素的细胞聚集,病理学检查诊断为转移性MM低倍放大
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