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中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (05) : 734 -738. doi: 10.3877/cma.j.issn.1674-6902.2023.05.037

综述

新辅助免疫治疗在可切除非小细胞肺癌中的研究进展
孟芸畅, 许可, 宋勇()   
  1. 210002 南京,南京医科大学金陵医院呼吸与危重症医学科
    210002 南京,南京大学医学院附属金陵医院呼吸与危重症医学科
    210002 南京,南京医科大学金陵医院呼吸与危重症医学科;210002 南京,南京大学医学院附属金陵医院呼吸与危重症医学科
  • 收稿日期:2023-02-12 出版日期:2023-10-25
  • 通信作者: 宋勇

Progress of neoadjuvant immunotherapy in resectable non-small cell lung cancer

Yunchang Meng, Ke Xu, Yong Song()   

  • Received:2023-02-12 Published:2023-10-25
  • Corresponding author: Yong Song
引用本文:

孟芸畅, 许可, 宋勇. 新辅助免疫治疗在可切除非小细胞肺癌中的研究进展[J]. 中华肺部疾病杂志(电子版), 2023, 16(05): 734-738.

Yunchang Meng, Ke Xu, Yong Song. Progress of neoadjuvant immunotherapy in resectable non-small cell lung cancer[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(05): 734-738.

2020年全球癌症调查报告,肺癌高居癌症相关死亡的首位,其发病率仅次于乳腺癌[1,2,3]。肺癌的主要病理类型为非小细胞肺癌(non-small cell lung cancer, NSCLC),约占肺癌的95%,其中,可切除的NSCLC患者通常接受手术和围手术期辅助化疗。研究表明,基于细胞毒药物的传统围手术期化疗,其生存率仅比单纯手术提高5.4%,3级及以上的毒副反应率却随之升高60%,且相较于术后辅助化疗,术前新辅助化疗的效果不尽如人意[4,5,6]。近年来,随着以阻断程序性死亡(programmed death-1, PD-1)蛋白信号通路抗体为代表的免疫检查点抑制剂(immune checkpoint inhibitors, ICIs)的出现,越来越多的证据支持新辅助免疫治疗在可切除NSCLC的显著疗效[7,8,9]。本综述阐述了目前在可切除NSCLC患者群体中,新辅助免疫治疗临床试验的疗效及安全性,总结新辅助免疫治疗所面临的挑战,为未来新辅助免疫治疗的发展提供一些观点。

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