分析呋喃唑酮(furazolidone)致间质性肺疾病(interstitial lung disease, ILD)患者临床资料，以提高对ILD诊疗水平。

选择我院收治的3例呋喃唑酮致间质性肺疾病患者，分析临床资料。

3例患者中男1例，女2例，年龄分别为40岁、23岁和39岁。临床表现为服用"呋喃唑酮"第10 d出现发热、活动后胸闷，2例伴间断性干咳，1例伴乏力、肌痛，1例伴恶心、头痛症状。实验室检测3例患者白细胞计数(10.9~13.9)×10⁹/L、中性粒细胞计数(8.98~12.44)×10⁹/L和C反应蛋白(19.14~287.52)mg/L升高，嗜酸性粒细胞计数正常。3例患者胸部CT表现为双肺光滑性小叶间隔增厚，其中2例伴磨玻璃影，病灶呈上肺分布、靠近肺内中带。3例患者诺氏评估量表评分均为7分，结合用药史及影像表现，排除心源性肺水肿、其他药物和接触源所致间质性肺疾病后诊断为呋喃唑酮致间质性肺疾病，停用呋喃唑酮并静脉滴注琥珀酸甲泼尼龙抗炎治疗后症状改善，复查胸部CT提示病灶吸收。

服用呋喃唑酮期间出现发热、胸闷，若胸部CT表现为两肺光滑性小叶间隔增厚伴或不伴有磨玻璃影，需考虑呋喃唑酮致间质性肺疾病，予停用呋喃唑酮和抗炎治疗，预后良好。

To improve diagnosis and treatment level of furazolidone-induced interstitial lung disease by analyzing the clinical data of patients.

Retrospective analysis of three patients diagnosed with furazolidone-induced interstitial lung disease in South China Hospital Affiliated to Shenzhen University.

The study included one male and two female patients, aged 40, 23, and 39 years old respectively. All patients experienced fever and exertional chest tightness on the 10th day of furazolidone treatment, two cases with intermittent dry cough, while one case with fatigue and myalgia, as well as one case with nausea and headache. Laboratory examination results revealed the leukocyte count (10.9~13.9) ×10⁹/L, neutrophil count (8.98~12.44) ×10⁹/L and C-reactive protein (19.14~287.52) mg/L were significantly increased, while eosinophils counts were normal. Chest CT scans indicated that smooth interlobular septal thickening in both lungs of all patients, while two of them were accompanied by ground-glass opacities localized in upper lungs near central pulmonary regions. The Nord′s score of all three patients was 7. By analyzing medication history and imaging characteristics, furazolidone-induced interstitial lung disease was diagnosed after excluding cardiogenic pulmonary edema, or interstitial lung disease caused by other drugs and exposures. Discontinuation of furazolidone along with intravenous infusion of methylprednisolone succinate for anti-inflammatory treatment resulted in symptom improvement, while repeat chest CT scan showed absorption of lesions further supporting the diagnosis.

In cases of fever and chest tightness during furazolidone treatment, furazolidone-induced interstitial lung disease should be considered if chest CT scan reveals smooth interlobular septal thickening in both lungs, with or without ground-glass opacities. Discontinuation of furazolidone and initiation of anti-inflammatory therapy could typically lead to favorable outcomes.