To explore the effect of tiotropium bromide assisted bilevel positive airway pressure ventilation on the levels of serum matrix metalloproteinase -9(MMP-9) and tumor necrosis factor-α(TNF-α)in patients with chronic obstructive pulmonary disease(COPD).

From September 2013 to September 2015, 74 cases of chronic obstructive pulmonary disease patients was stuided in our hospital. According to randomly divided into three groups, respectively with tiotropium bromide 25 cases, single bilevel positive airway pressure ventilation 23 cases and combination therapy 26 cases. The levels of MMP-9 and TNF-α in serum of three groups before and after treatment were compared, and the level of pulmonary function, treatment effect and adverse reaction were observed.

The serum of TNF-α, MMP-9 contentafter treatmentwere lower than before treatment (P<0.05), combined treatment group in serum of patients with MMP-9 and TNF-α was significantly lower than that in the tiotropium bromide group or BiPAP group (P<0.05); three groups of patients after treatment, lung function index of FEV₁, FVC, FEV₁/FVC, PEF compared with before treatment were improved (P<0.05), combined treatment group after treatment in patients with FEV₁, FVC, FEV₁/FVC and PEF were higher than those in the tiotropium bromide group or BiPAP group (P<0.05); tiotropium bromide in the treatment of COPD with 77.50% efficiency, BiPAP COPD treatment efficiency was 75%, the efficiency of combined treatment of COPD 88.75%, the effect of the combined treatment was better than that of BiPAP group (P<0.05); but the effective rate of combination therapy group was not statistically significant compared with that of tiotropium group (P>0.05). the incidence of 1 years recurrence and adverse reactions of three groups were compared after treatment, combined treatment of the recurrence rate of COPD was significantly lower than that of tiotropium bromide or BiPAP treatment (P<0.05) there was no significant difference in the incidence of adverse reactions between the three treatments in the last 1 years (P>0.05).

Tiotropium bromide assisted bilevel positive airway pressure ventilation in treatment of chronic obstructive pulmonary disease, with significant curative effect, can effectively improve patients′lung function, and can reduce the content of MMP-9, TNF-α in serum, and recurrence rate of patients with COPD is lower.