To explore the diagnostic values of combined detection of two-dimensional echocardiography, B-type brain natriuretic peptide (BNP), 6-minute walking test (6MWT) and Modified Medical Research Council dyspnea scale (MMRC) for the right ventricular dysfunction in the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

From May 2016 to May 2018, the patients with clinically-confirmed AECOPD in the Emergency Department of our hospital were selected as the research subjects. The general data were collected and BNP, 6MWT, MMRC and two-dimensional echocardiographic experimental indicators were measured. Statistical analysis was made on the difference between the two-dimensional echocardiographic indicators and BNP, 6MWT and MMRC in the diagnosis of the right ventricular dysfunction in AECOPD patients.

Among the 249 patients with AECOPD, 94 (37.8%) were positive and 155 (62.2%) were normal according to the judgment of the right ventricular insufficiency by any of the four test indicators of the two-dimensional echocardiography. Statistical analysis showed that there were significant differences between the two-dimensional echocardiography and BNP, 6MWT and MMRC (P<0.05). The difference between the positive results of the two-dimensional echocardiography and BNP, 6MWT and MMRC was statistically significant by Chi-square test (P<0.05). The positive and negative percentages of the two-dimensional echocardiography combined with any item of BNP, 6MWT and MMRC were 67.9%, 42.6% and 54.2%, respectively, which showed that the two-dimensional echocardiography combined with BNP was superior to the other combinations. The percentages of positive and negative results of the two-dimensional echocardiography combined with any two items of BNP, 6MWT and MMRC were 44.6%, 36.1%, and 42.2%, respectively, which showed that BNP+ 6MWT+ two-dimensional echocardiography was superior to the other combinations.

The combined detection of two-dimensional echocardiography, BNP, 6WMT and MMRC is superior to any single detection in the diagnosis of the right heart insufficiency in the patients with AECOPD, and the BNP+ ultrasound detection group is superior to the other combinations, which can be used as the first choice for the diagnosis of COPD patients with right ventricular insufficiency.