Correlation analysis between cognitive level and cancer-related fatigue in patients with non-small cell lung cancer

doi:10.3877/cma.j.issn.1674-6902.2025.03.020

Abstract

Abstract:

Objective

To analyze the correlation between cognitive level and cancer-related fatigue in patients with non-small cell lung cancer （NSCLC），and to improve the quality of life in patients with NSCLC.

Methods

All of 75 patients with NSCLC admitted to the First Affiliated Hospital of Air Force Medical University from January 2021 to December 2023 were selected as subjects. Clinical data questionnaire and minimental status examination （MMSE）and revised Piper fatigue scale （RPFS） were used to investigate MMSE score and RPFS score of NSCLC patients，and to analyze the cognitive level and cancer-related fatigue status of NSCLC patients. Pearson correlation was used to analyze the correlation between the cognitive scores of NSCLC patients in each dimension （orientation，immediate memory，attention and computation，recall ability，language ability and total score） and the behavioral dimension，emotional dimension，sensory dimension，cognitive dimension and fatigue score of cancer-related fatigue.

Results

The total score of NSCLC patients' cognitive level was （24.68±4.17），and the average score was （0.85±0.12）. The incidence of cancer-related fatigue in 75 patients was 100%，and RPFS score was behavioral dimension （10.68±2.17），emotional dimension（12.44±2.12），ensory dimension（15.31±2.88），cognitive dimension，（15.44±3.52） and total fatigue（53.78±8.45）. Pearson correlation analysis showed that the cognitive scores of NSCLC patients in each dimension（orientation，immediate memory，attention and computation，recall ability，language ability，total score） were negatively correlated with the behavioral dimension，emotional dimension，cognitive dimension，and total fatigue score （P＜0.001）. In the 75 patients with NSCLC，6 cases（8%） died in 6 months after discharge，among which the causes of death were pulmonary infection in 4 cases （66.62%），respiratory failure in 1 case（16.67%） and brain metastasis in 1 case （16.67%）.

Conclusion

The cognitive level of NSCLC patients is closely related to cancer-related fatigue，and improving the cognitive level of NSCLC patients has clinical significance in alleviating cancer-related fatigue.

Key words: Non-small cell lung cancer, Cognitive level, Cancer-related fatigue, Mini-mental status examination, Revised Piper fatigue scale

Juanli Shi, Xiaoli Long, Geng Xiang, Xiao Zhang, Zhuowei Shi. Correlation analysis between cognitive level and cancer-related fatigue in patients with non-small cell lung cancer[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2025, 18(03): 452-456.

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References 24

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MMSE 项目	实际得分
定向力	9.29±0.97
即刻记忆	2.66±0.62
注意力和计算力	3.97±0.99
回忆能力	2.12±0.68
语言能力	7.25±1.19
总分	24.68±4.17

MMSE 项目	实际得分
定向力	9.29±0.97
即刻记忆	2.66±0.62
注意力和计算力	3.97±0.99
回忆能力	2.12±0.68
语言能力	7.25±1.19
总分	24.68±4.17

项目	行为维度	情感维度	感觉维度	认知维度	总疲乏得分
定向力
r	-0.984	-0.991	-0.122	-0.985	-0.986
P	0.001	0.001	0.321	0.001	0.001
即刻记忆
r	-0.997	-0.989	-0.145	-0.981	-0.991
P	0.001	0.001	0.188	0.001	0.001
注意力和计算力
r	-0.993	-0.985	-0.121	-0.997	-0.993
P	0.001	0.001	0.088	0.001	0.001
回忆能力
r	-0.981	-0.994	-0.176	-0.974	-0.974
P	0.001	0.001	0.134	0.001	0.001
语言能力
r	-0.992	-0.989	-0.226	-0.993	-0.989
P	0.001	0.001	0.365	0.001	0.001
总分
r	-0.988	-0.979	-0.289	-0.988	-0.992
P	0.001	0.001	0.416	0.001	0.001

项目	行为维度	情感维度	感觉维度	认知维度	总疲乏得分
定向力
r	-0.984	-0.991	-0.122	-0.985	-0.986
P	0.001	0.001	0.321	0.001	0.001
即刻记忆
r	-0.997	-0.989	-0.145	-0.981	-0.991
P	0.001	0.001	0.188	0.001	0.001
注意力和计算力
r	-0.993	-0.985	-0.121	-0.997	-0.993
P	0.001	0.001	0.088	0.001	0.001
回忆能力
r	-0.981	-0.994	-0.176	-0.974	-0.974
P	0.001	0.001	0.134	0.001	0.001
语言能力
r	-0.992	-0.989	-0.226	-0.993	-0.989
P	0.001	0.001	0.365	0.001	0.001
总分
r	-0.988	-0.979	-0.289	-0.988	-0.992
P	0.001	0.001	0.416	0.001	0.001

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