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中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (02) : 190 -194. doi: 10.3877/cma.j.issn.1674-6902.2023.02.008

所属专题: 经典病例

论著

原发性肺黏液腺癌文献复习并3例报道
王妮妮1, 陈荣荣1, 张青1, 张诚实1, 崔栋慧1, 伍健2, 雷撼1, 赵云峰1,()   
  1. 1. 200125 上海,上海市浦东新区浦南医院呼吸内科
    2. 200125 上海,上海市浦东新区浦南医院病理科
  • 收稿日期:2022-10-13 出版日期:2023-04-25
  • 通信作者: 赵云峰
  • 基金资助:
    上海市浦东新区卫生系统重点亚专科建设资助(PWZy2020-15); 上海市浦东新区卫生系统临床特色学科建设资助(PWYts2021-04); 上海市浦东新区卫生系统重点学科建设资助(PWZxk2022-24)

Primary mucinous adenocarcinoma of the lung: three cases report and literature review

Nini Wang1, Rongrong Chen1, Qing Zhang1, Chengshi Zhang1, Donghui Cui1, Jian Wu2, Han Lei1, Yunfeng Zhao1,()   

  1. 1. Department of Respiratory, Pudong New Area, Shanghai 200125, China
    2. Department of pathology Punan Hospital, Pudong New Area, Shanghai 200125, China
  • Received:2022-10-13 Published:2023-04-25
  • Corresponding author: Yunfeng Zhao
引用本文:

王妮妮, 陈荣荣, 张青, 张诚实, 崔栋慧, 伍健, 雷撼, 赵云峰. 原发性肺黏液腺癌文献复习并3例报道[J]. 中华肺部疾病杂志(电子版), 2023, 16(02): 190-194.

Nini Wang, Rongrong Chen, Qing Zhang, Chengshi Zhang, Donghui Cui, Jian Wu, Han Lei, Yunfeng Zhao. Primary mucinous adenocarcinoma of the lung: three cases report and literature review[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(02): 190-194.

目的

分析原发性肺黏液腺癌(primary pulmonary mucinous adenocarcinoma, PPMA)的临床表现、影像学特征、病理特点、治疗等,提高临床对该病的认识。

方法

选择2022年6月至2022年10月收治的3例原发性肺黏液腺癌的临床诊治经过,3例为女性,年龄73~85岁,为高龄。结合文献复习,提高对原发性肺黏液腺癌临床表现、影像学特征、病理特点等认识,提高诊断及治疗水平。

结果

原发性肺黏液腺癌以浸润性黏液腺癌为主,临床表现无特异性,易被误诊,诊断主要依靠病理,治疗以早期手术为主。

结论

原发性肺黏液腺癌是肺腺癌的一种特殊亚型,临床诊断缺乏特异性,诊断主要依赖活组织病理。

Objective

To investigate the clinical manifestations, imaging features and pathological characteristics of primary pulmonary mucinous adenocarcinoma (PPMA) and improve the understanding of the disease.

Methods

Through the clinical diagnosis and treatment of 3 cases of primary mucinous lung adenocarcinoma from June 2022 to October 2022 was analyzed. All of them were female, aged 73 to 85 old. Combined with literature analysis and literature review, to strengthen clinicians′understanding of the clinical manifestations, imaging characteristics and pathological characteristics of this disease, improve the level of diagnosis and treatment.

Results

The primary mucinous adenocarcinoma of the lung was mainly invasive mucinous adenocarcinoma. The clinical manifestations were not specific, and it was easy to be misdiagnosed. The diagnosis mainly depended on pathology, and the treatment was mainly early operation.

Conclusion

PPMA is a special subtype of lung adenocarcinoma with low incidence and poor prognosis. The lack of specificity in clinical diagnosis mainly depends on biopsy.

图2 患者CT及病例组织学表达。注:A:左上肺病灶,呈"结节型";B:HE染色可见高柱状肿瘤上皮细胞(×400);C:免疫组化染色显示CK7(B)阳性(×400);D:红色箭头提示TTF-1在肿瘤细胞阴性表达(×100);E:NapsiA阴性(×400)
图3 患者CT及病例组织学表达。注:A:右下肺病灶,呈"结节型";B:HE染色可见高柱状腺上皮,细胞核位于基底,胞浆内可见大量黏液(×400); C:HE染色胞腔内可见大量肺上皮细胞(×400);D:免疫组化染色显示CK7阳性(×400);E:NapsiA阴性(×400)
图1 患者CT及病例组织学表达。注:A:右下肺病灶,呈"炎症型";B:HE染色提示显示柱状肿瘤细胞胞浆内含有丰富黏蛋白,细胞核位于基底(×400);C:免疫组化染色显示CK7(B)阳性(×400);D:红色箭头提示TTF-1在肿瘤细胞阴性表达,黄色箭头表示在正常细胞阳性表达(×100);E:NapsiA阴性(×400)
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