To analyse the severity of disease and the evaluation of serum quality of life value of serumal soluble human stromelysin-2 and procalcitonin in the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

The serumal soluble human stromelysin-2, procalcitonin, C reactive protein were detected in 120 hospitalized AECOPD patients before and after the treatment, and to study the correlation above indexes with severity of COPD, COPD assessment test(CAT) and 6 minutes walk distance (6MWD).

Compared with after the treatment patients and healthy control group, serumal levels of the soluble human stromelysin-2, procalcitonin, C-reactive protein were significantly elevated in the patient with AECOPD before the treatment(P<0.05). To some extent, the levels of these indicators were increasing with the increase in the severity of the disease. The severity classification of COPD were positively correlated with serum sST2, CRP and PCT levels (r=0.588, r=0.132, r=0.305, P<0.01), serum sST2 level of the combined Class Ⅰ and Ⅱ COPD patients was significantly lower than the combined Class Ⅲ and Ⅳ COPD patients (t=9.600, P<0.01). The serumal sST2 was positively correlated with CAT (r=0.363, P<0.01), and was negatively correlated with 6MWD (r=-0.434, P<0.01).

The serumal sST2 levels in Ⅲ, Ⅳ level AECOPD patients were higher than Ⅰ, Ⅱ stage AECOPD patients, and with the condition improved, serumal sST2 decreased significantly. Serumal sST2 can reflect the severity of AECOPD patients in some extent, and has certain clinical value to evaluate the condition of AECOPD patients.