Index changes of serumal soluble human stromelysin-2 and procalcitonin assess the patients of AECOPD

doi:10.3877/cma.j.issn.1674-6902.2017.02.015

Abstract

Abstract:

Objective

To analyse the severity of disease and the evaluation of serum quality of life value of serumal soluble human stromelysin-2 and procalcitonin in the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

Methods

The serumal soluble human stromelysin-2, procalcitonin, C reactive protein were detected in 120 hospitalized AECOPD patients before and after the treatment, and to study the correlation above indexes with severity of COPD, COPD assessment test(CAT) and 6 minutes walk distance (6MWD).

Results

Compared with after the treatment patients and healthy control group, serumal levels of the soluble human stromelysin-2, procalcitonin, C-reactive protein were significantly elevated in the patient with AECOPD before the treatment(P<0.05). To some extent, the levels of these indicators were increasing with the increase in the severity of the disease. The severity classification of COPD were positively correlated with serum sST2, CRP and PCT levels (r=0.588, r=0.132, r=0.305, P<0.01), serum sST2 level of the combined Class Ⅰ and Ⅱ COPD patients was significantly lower than the combined Class Ⅲ and Ⅳ COPD patients (t=9.600, P<0.01). The serumal sST2 was positively correlated with CAT (r=0.363, P<0.01), and was negatively correlated with 6MWD (r=-0.434, P<0.01).

Conclusions

The serumal sST2 levels in Ⅲ, Ⅳ level AECOPD patients were higher than Ⅰ, Ⅱ stage AECOPD patients, and with the condition improved, serumal sST2 decreased significantly. Serumal sST2 can reflect the severity of AECOPD patients in some extent, and has certain clinical value to evaluate the condition of AECOPD patients.

Key words: Acute exacerbation of chronic obstructive pulmonary disease, Soluble human stromelysin-2, Procalcitonin, C-reactive protein, COPD assessment test, 6 minutes walk test

Moran Zhu, Defeng Xu, Yunfeng Zhao, Jinming Liu, Lei Zhao. Index changes of serumal soluble human stromelysin-2 and procalcitonin assess the patients of AECOPD[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2017, 10(02): 187-191.

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Figures/Tables 3

References 22

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分　级	治疗前/后	CRP(mg/L)	PCT(ng/ml)	sST2(ng/L)
Ⅰ级(n＝30)	治疗前	22.33±16.05	0.24±0.13	107.96±46.71
?	治疗后	4.87±3.06	0.06±0.05	72.24±12.25
?	t值	2.426	3.014	4.878
?	前后比较P值	0.022	0.005	0.000
Ⅱ级(n＝30)	治疗前	30.02±20.17	0.32±0.19	178.57±66.62
?	治疗后	6.04±4.43	0.03±0.02	90.66±29.44
?	t值	3.281	4.112	10.216
?	前后比较P值	0.003	0.000	0.000
Ⅲ级(n＝30)	治疗前	25.14±17.17	1.32±0.29	238.93±101.44
?	治疗后	7.16±3.58	0.33±0.12	89.03±18.13
?	t值	3.663	2.520	8.835
?	前后比较P值	0.001	0.017	0.000
Ⅳ级(n＝30)	治疗前	63.43±28.82	3.60±1.20	394.67±88.60
?	治疗后	8.84±4.51	0.04±0.01	114.41±29.95
?	t值	5.426	5.024	17.438
?	前后比较P值	0.000	0.000	0.000
对照组(n＝30)	?	0.99±0.90	0.06±0.05	66.91±8.20
?	t值	7.167	3.072	13.476
?	与AECOPD患者治疗后P值	0.000	0.003	0.000

分　级	治疗前/后	CRP(mg/L)	PCT(ng/ml)	sST2(ng/L)
Ⅰ级(n＝30)	治疗前	22.33±16.05	0.24±0.13	107.96±46.71
?	治疗后	4.87±3.06	0.06±0.05	72.24±12.25
?	t值	2.426	3.014	4.878
?	前后比较P值	0.022	0.005	0.000
Ⅱ级(n＝30)	治疗前	30.02±20.17	0.32±0.19	178.57±66.62
?	治疗后	6.04±4.43	0.03±0.02	90.66±29.44
?	t值	3.281	4.112	10.216
?	前后比较P值	0.003	0.000	0.000
Ⅲ级(n＝30)	治疗前	25.14±17.17	1.32±0.29	238.93±101.44
?	治疗后	7.16±3.58	0.33±0.12	89.03±18.13
?	t值	3.663	2.520	8.835
?	前后比较P值	0.001	0.017	0.000
Ⅳ级(n＝30)	治疗前	63.43±28.82	3.60±1.20	394.67±88.60
?	治疗后	8.84±4.51	0.04±0.01	114.41±29.95
?	t值	5.426	5.024	17.438
?	前后比较P值	0.000	0.000	0.000
对照组(n＝30)	?	0.99±0.90	0.06±0.05	66.91±8.20
?	t值	7.167	3.072	13.476
?	与AECOPD患者治疗后P值	0.000	0.003	0.000

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