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中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (02) : 281 -284. doi: 10.3877/cma.j.issn.1674-6902.2023.02.037

综述

Wnt/β-Catenin通路促进非小细胞肺癌转移机制研究进展
李多1, 郝昭昭1, 陈延伟1, 南岩东1,()   
  1. 1. 710038 西安,空军军医大学唐都医院呼吸内科
  • 收稿日期:2022-09-27 出版日期:2023-04-25
  • 通信作者: 南岩东
  • 基金资助:
    陕西省重点研发计划(2019SF-009); 唐都医院高层次人才启动项目(2021YFJH0011)

Progress of Wnt/β-Catenin in the mechanism of metastasis in non-small cell lung cancer

Duo Li1, Zhaozhao Hao1, Tingwei Cheng1   

  • Received:2022-09-27 Published:2023-04-25
引用本文:

李多, 郝昭昭, 陈延伟, 南岩东. Wnt/β-Catenin通路促进非小细胞肺癌转移机制研究进展[J]. 中华肺部疾病杂志(电子版), 2023, 16(02): 281-284.

Duo Li, Zhaozhao Hao, Tingwei Cheng. Progress of Wnt/β-Catenin in the mechanism of metastasis in non-small cell lung cancer[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(02): 281-284.

原发性肺癌是全球发病率第二,病死率第一的恶性肿瘤,其中非小细胞肺癌(non-small cell lung cancer, NSCLC)为最常见病理类型,占比约80%~85%[1,2]。NSCLC转移发生率高,约30%~40%新确诊病例已发生远处转移,最常见转移部位是骨骼,其次是肺、脑、肾上腺、肝、淋巴结等[3]。远处转移性NSCLC已失去根治性手术时机,易出现各种转移并发症,严重威胁患者生活质量,5年生存率低于5%[4]。NSCLC转移是一个涉及多因子、多步骤的复杂生物学过程。Wnt/β-Catenin通路在NSCLC转移过程的多个关键环节发挥重要作用,已成为癌症转移临床前和临床评估中主要干预目标。本文主要就Wnt/β-Catenin通路促进NSCLC转移有关机制研究进展作一综述。

1
吴国明,钱桂生. 非小细胞肺癌靶向治疗研究进展及新理念[J/CD]. 中华肺部疾病杂志(电子版), 2019, 12(4): 405-408.
2
马蓉蓉,明宗娟,李 维,等. 肺腺癌病理类型转化特征及耐药机制分析[J/CD]. 中华肺部疾病杂志(电子版), 202215(6): 782-786.
3
Tamura T, Kurishima K, Nakazawa K, et al. Specific organ metastases and survival in metastatic non-small-cell lung cancer[J]. Mol Clin Oncol, 2015, 3(1): 217-221.
4
Ko EC, Raben D, Formenti SCJC. The integration of radiotherapy with immunotherapy for the treatment of non-small cell lung cancer[J]. Clin Cancer Res, 2018, 24(23): 5792-5806.
5
Liu J, Xiao Q, Xiao J, et al. Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities[J]. Signal Transduct Target Ther, 2022, 7(1): 3.
6
Agostino M, Pohl . The structural biology of canonical Wnt signalling[J]. Biochem Soc Trans, 2020, 48(4): 1765-1780.
7
Zheng H, Ning Y, Yang Y, et al. Aberrant expression of β-catenin correlates with infiltrating immune cells and prognosis in NSCLC[J]. Pathol Oncol Res, 2021, 27: 1609981.
8
Stewart DJ. Wnt signaling pathway in non-small cell lung cancer[J]. J Natl Cancer Inst, 2014, 106(1): t356.
9
Das B, Sinha D. Diallyl disulphide suppresses the cannonical Wnt signaling pathway and reverses the fibronectin-induced epithelial mesenchymal transition of A549 lung cancer cells[J]. Food Funct, 2019, 10(1): 191-202.
10
Lamouille S, Xu J, Derynck RJNR. Molecular mechanisms of epithelial-mesenchymal transition[J]. Nat Rev Mol Cell Biol, 2014, 15(3): 178-196.
11
Valenta T, Hausmann G, Basler K. The many faces and functions of β-catenin[J]. EMBO J, 2012, 31(12): 2714-2736.
12
Shi J, Li C, Wang H, et al. NUP58 facilitates metastasis and epithelial-mesenchymal transition of lung adenocarcinoma via the GSK-3β/Snail signaling pathway[J]. Am J Transl Res, 2019, 11(1): 393-405.
13
Hu Y, Mu H, Yang Y. Histone demethylase PHF8 promotes cell growth and metastasis of non-small-cell lung cancer through activating Wnt/β-catenin signaling pathway[J]. Histol Histopathol, 2021, 36(8): 869-877.
14
Yang Y, Sun Y, Wu Y, et al. Downregulation of miR-3127-5p promotes epithelial-mesenchymal transition via FZD4 regulation of Wnt/β-catenin signaling in non-small-cell lung cancer[J]. Mol Carcinog, 2018, 57(7): 842-853.
15
Yang S, Liu Y, Li M Y, et al. FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer[J]. Mol Cancer, 2017, 16(1): 124.
16
Huang JQ, Wei FK, Xu XL, et al. SOX9 drives the epithelial-mesenchymal transition in non-small-cell lung cancer through the Wnt/β-catenin pathway[J]. J Transl Med, 2019, 17(1): 143.
17
Xue S, Wu W, Wang Z, et al. USP5 promotes metastasis in non-small cell lung cancer by inducing epithelial-mesenchymal transition via Wnt/β-catenin pathway[J]. Front Pharmacol, 2020, 11: 668.
18
Xia C, Xu X, Ding Y, et al. Abnormal spindle-like microcephaly-associated protein enhances cell invasion through Wnt/β-catenin-dependent regulation of epithelial-mesenchymal transition in non-small cell lung cancer cells[J]. J Thorac Dis, 2021, 13(4): 2460-2474.
19
Olsen JJ, Pohl Deshmukh A, et al. The role of wnt sgnalling in angiogenesis[J]. Clin Biochem Rev, 2017, 38(3): 131-142.
20
Judit R. The role of wnt signaling in the decelopment and treatment of non-small cell lung cancer[D]. University of Pécs, 2017: 78-96.
21
Shukla S, Sinha S, Khan S, et al. Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis[J]. Sci Rep, 2016, 6: 21860.
22
Fernández Jaime G, Rodríguez Diego A, Valenzuela Manuel, et al. Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription[J]. Mol Cancer, 2014, 13: 209.
23
Yeo Eun-Jin, Cassetta Luca, Qian Bin-Zhi, et al. Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer[J]. Cancer Res, 2014, 74(11): 2962-2973.
24
Huang CL, Liu D, Ishikawa S, et al. Wnt1 overexpression promotes tumour progression in non-small cell lung cancer[J]. Eur J Cancer, 2008, 44(17): 2680-2688.
25
Rapp Judit, Jaromi Luca, Kvell Krisztian, et al. WNT signaling-lung cancer is no exception[J]. Respir Res, 2017, 18(1): 167.
26
Choe Youngshik, Pleasure Samuel J. Wnt signaling regulates intermediate precursor production in the postnatal dentate gyrus by regulating CXCR4 expression[J]. Dev Neurosci, 2012, 34(6): 502-514.
27
Nguyen Don X, Chiang Anne C, Zhang Xiang H-F, et al. WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis[J]. Cell, 2009, 138(1): 51-62.
28
Li Huanhuan, Tong Fan, Meng Rui, et al. E2F1-mediated repression of WNT5A expression promotes brain metastasis dependent on the ERK1/2 pathway in EGFR-mutant non-small cell lung cancer[J]. Cell Mol Life Sci, 2021, 78(6): 2877-2891.
29
Zhang Hui-Juan, Chang Wen-Jing, Jia Cai-Yun, et al. Destrin contributes to lung adenocarcinoma progression by activating Wnt/β-catenin signaling pathway[J]. Mol Cancer Res, 202018(12): 1789-1802.
30
She Kelin, Yang Wensheng, Li Mengna, et al. FAIM2 Promotes non-small cell lung cancer cell growth and bone metastasis by activating the Wnt/β-catenin pathway[J]. Front Oncol, 2021, 11: 690142.
31
Liu Liyun, Zhu Hongrui, Liao Yahui, et al. Inhibition of Wnt/β-catenin pathway reverses multi-drug resistance and EMT in Oct4(+)/Nanog(+) NSCLC cells[J]. Biomed Pharmacother, 2020, 127: 110225.
32
Gong Liyun, Song Junwei, Lin Xi, et al. Serine-arginine protein kinase 1 promotes a cancer stem cell-like phenotype through activation of Wnt/β-catenin signalling in NSCLC[J]. J Pathol, 2016, 240(2): 184-196.
33
Shu Xiong, Chen Meng, Liu Shi-Ya, et al. Palladin promotes cancer stem cell-like properties in lung cancer by activating Wnt/β-catenin signaling[J]. Cancer Med, 2022, 12(4): 4510-4520.
34
Su Jie, Wu Shifei, Wu Haiyang, et al. CD44 is functionally crucial for driving lung cancer stem cells metastasis through Wnt/β-catenin-FoxM1-Twist signaling[J]. Mol Carcinog, 2016, 55(12): 1962-1973.
35
Ma Yunxia, Marinkova Rumyana, Nenkov Miljana, et al. Tumor-intrinsic PD-L1 exerts an oncogenic function through the activation of the Wnt/β-catenin pathway in human non-small cell lung cancer[J]. Int J Mol Sci, 2022, 23(19): 11031.
36
Scheel Andreas H, Ansén Sascha, Schultheis Anne M, et al. PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations[J]. Oncoimmunology, 2016, 5(5): e1131379.
37
Hung Pei-Shan, Huang Ming-Hung, Kuo Yuan-Yeh, et al. The inhibition of wnt restrain KRAS(G12V)-driven metastasis in non-small-cell lung cancer[J]. Cancers (Basel), 2020, 12(4): 837.
38
Wang Qiang, Liao Jinrong, He Zhiyong, et al. LHX6 affects erlotinib resistance and migration of EGFR-mutant non-small-cell lung cancer HCC827 cells through suppressing Wnt/β-catenin signaling[J]. Onco Targets Ther, 2020, 13: 10983-10994.
39
Cai Junchao, Fang Lishan, Huang Yongbo, et al. Publisher Correction:Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC[J]. Nat Commun, 2018, 9: 16196.
40
Wang Yang, He Bo, Dong Yan, et al. Homeobox-A13 acts as a functional prognostic and diagnostic biomarker via regulating P53 and Wnt signaling pathways in lung cancer[J]. Cancer Biomark, 2021, 31(3): 239-254.
41
Jiang Neng, Zou Chang, Zhu Ying, et al. HIF-1ɑ-regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt/β-catenin and Notch signaling[J]. Theranostics, 2020, 10(6): 2553-2570.
42
Johnson Rachelle W, Merkel Alyssa R, Page Jonathan M, et al. Wnt signaling induces gene expression of factors associated with bone destruction in lung and breast cancer[J]. Clin Exp Metastasis, 2014, 31(8): 945-959.
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