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中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (02) : 281 -284. doi: 10.3877/cma.j.issn.1674-6902.2023.02.037

综述

Wnt/β-Catenin通路促进非小细胞肺癌转移机制研究进展
李多1, 郝昭昭1, 陈延伟1, 南岩东1,()   
  1. 1. 710038 西安,空军军医大学唐都医院呼吸内科
  • 收稿日期:2022-09-27 出版日期:2023-04-25
  • 通信作者: 南岩东
  • 基金资助:
    陕西省重点研发计划(2019SF-009); 唐都医院高层次人才启动项目(2021YFJH0011)

Progress of Wnt/β-Catenin in the mechanism of metastasis in non-small cell lung cancer

Duo Li1, Zhaozhao Hao1, Tingwei Cheng1   

  • Received:2022-09-27 Published:2023-04-25
引用本文:

李多, 郝昭昭, 陈延伟, 南岩东. Wnt/β-Catenin通路促进非小细胞肺癌转移机制研究进展[J]. 中华肺部疾病杂志(电子版), 2023, 16(02): 281-284.

Duo Li, Zhaozhao Hao, Tingwei Cheng. Progress of Wnt/β-Catenin in the mechanism of metastasis in non-small cell lung cancer[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(02): 281-284.

原发性肺癌是全球发病率第二,病死率第一的恶性肿瘤,其中非小细胞肺癌(non-small cell lung cancer, NSCLC)为最常见病理类型,占比约80%~85%[1,2]。NSCLC转移发生率高,约30%~40%新确诊病例已发生远处转移,最常见转移部位是骨骼,其次是肺、脑、肾上腺、肝、淋巴结等[3]。远处转移性NSCLC已失去根治性手术时机,易出现各种转移并发症,严重威胁患者生活质量,5年生存率低于5%[4]。NSCLC转移是一个涉及多因子、多步骤的复杂生物学过程。Wnt/β-Catenin通路在NSCLC转移过程的多个关键环节发挥重要作用,已成为癌症转移临床前和临床评估中主要干预目标。本文主要就Wnt/β-Catenin通路促进NSCLC转移有关机制研究进展作一综述。

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