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中华肺部疾病杂志(电子版) ›› 2024, Vol. 17 ›› Issue (01) : 123 -126. doi: 10.3877/cma.j.issn.1674-6902.2024.01.026

临床研究

AECOPD患者肺功能指标与血清白介素相关因子水平的关系
商焕霞1, 郭立娟1, 张罗元1, 徐婵2, 席素雅3,()   
  1. 1. 050041 石家庄,河北省胸科医院呼吸与危重症医学科
    2. 050800 石家庄,河北省正定县人民医院内科
    3. 050041 石家庄,河北省胸科医院感染性疾病科
  • 收稿日期:2023-07-27 出版日期:2024-02-25
  • 通信作者: 席素雅

Relationship between pulmonary function indexes and serum interleukin­related factors in patients with AECOPD

Huanxia Shang, Lijuan Guo, Luoyuan Zhang   

  • Received:2023-07-27 Published:2024-02-25
引用本文:

商焕霞, 郭立娟, 张罗元, 徐婵, 席素雅. AECOPD患者肺功能指标与血清白介素相关因子水平的关系[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(01): 123-126.

Huanxia Shang, Lijuan Guo, Luoyuan Zhang. Relationship between pulmonary function indexes and serum interleukin­related factors in patients with AECOPD[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2024, 17(01): 123-126.

目的

分析慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease, AECOPD)患者血清白介素相关因子与肺功能的关系。

方法

选取2019年1月至2021年11月我院收治的COPD患者85例为对象,根据病情轻重分为稳定期COPD组42例,急性加重期COPD组(AECOPD)43例。检测IL-6、IL-10、IL-18、IL-19、IL-33、IL-35水平及肺功能指标[第一秒用力呼出气容积占预计值百分比(FEV1%pred)、第一秒用力呼出气容积/用力肺活量比值(FEV1/FVC%)],通过ROC分析血清白介素因子预测AECOPD的预后,通过Spearman秩分析IL-6、IL-10、IL-18、IL-19、IL-33、IL-35水平与肺功能指标的相关性。

结果

AECOPD组IL-6(25.69±7.58)pg/ml、IL-18(143.68±29.71)pg/ml、IL-19(2 256.46±521.49)pg/ml、IL-33(268.57±32.62)pg/ml水平高于稳定期COPD组,IL-10(3.67±1.24)pg/ml、IL-35(11.14±4.85)pg/ml低于稳定期COPD组,FEV1%pred(42.36±9.83)和FEV1/FVC%(45.38±10.27)水平低于稳定期COPD组(P<0.05);ROC分析IL-6、IL-10、IL-18、IL-19、IL-33、IL-35水平可用于AECOPD的预测,曲线下面积为0.852、0.776、0.850、0.676、0.800、0.861;通过Spearman秩相关分析检验AECOPD患者血清IL-6、IL-18、IL-19、IL-33水平与FEV1preed%和FEV1/FVC%呈负相关,IL-10、IL-35水平与FEV1preed%和FEV1/FVC%呈正相关(P<0.05)。

结论

血清IL-6、IL-10、IL-18、IL-19、IL-33、IL-35参与COPD的炎症反应,其表达水平与肺功能相关,可判断AECOPD病情具有临床意义。

表1 COPD患者、白介素因子及肺功能结果[n(%),(±s)]
表2 白介素相关因子预测AECOPD的ROC曲线分析
表3 血清白介素相关因子与肺功能指标的相关性
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