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中华肺部疾病杂志(电子版) ›› 2021, Vol. 14 ›› Issue (04) : 407 -411. doi: 10.3877/cma.j.issn.1674-6902.2021.04.001

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广泛期小细胞肺癌免疫治疗新理念
徐瑜1, 白莉1,()   
  1. 1. 400037 重庆,陆军(第三)军医大学第二附属医院呼吸与危重症医学科
  • 收稿日期:2021-06-15 出版日期:2021-08-25
  • 通信作者: 白莉
  • 基金资助:
    国家自然科学基金资助项目(81370139)

New concept of immunotherapy for extensivedisease of small cell lung cancer

Yu Xu1, Li Bai1()   

  • Received:2021-06-15 Published:2021-08-25
  • Corresponding author: Li Bai
引用本文:

徐瑜, 白莉. 广泛期小细胞肺癌免疫治疗新理念[J]. 中华肺部疾病杂志(电子版), 2021, 14(04): 407-411.

Yu Xu, Li Bai. New concept of immunotherapy for extensivedisease of small cell lung cancer[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2021, 14(04): 407-411.

1
Yang S, Zhang Z, Wang Q. Emerging therapies for small cell lung cancer[J]. J Hematol Oncol, 2019,12(1): 47.
2
Montenegro GB, Farid S, Liu SV. Immunotherapy in lung cancer[J]. J Surg Oncol, 2021, 123(3): 718-729.
3
Horn L, Mansfield AS, Szcz sna A, et al. First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer[J]. N Engl J Med, 2018, 379(23): 2220-2229.
4
Paz-Ares L, Dvorkin M, Chen Y, et al. Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial[J]. Lancet, 2019, 394(10212): 1929-1939.
5
Rudin CM, Awad MM, Navarro A, et al. Pembrolizumab or placebo plus etoposide and platinum as first-line therapy for extensive-stage small-cell lung cancer: randomized, double-blind, phase Ⅲ KEYNOTE-604 study[J]. J Clin Oncol, 2020, 38(21): 2369-2379.
6
Gadgeel SM, Pennell NA, Fidler MJ, et al. Phase Ⅱ study of maintenance pembrolizumab in patients with extensive-stage small cell lung cancer (SCLC) [J]. J Thorac Oncol, 2018, 13(9): 1393-1399.
7
Owonikoko TK, Park K, Govindan R, et al. Nivolumab and ipilimumab as maintenance therapy in extensive-disease small-cell lung cancer: CheckMate 451[J]. J Clin Oncol, 2021, 39(12): 1349-1359.
8
van Meerbeeck Jan P, Fennell Dean A, De Ruysscher Dirk KM. small-cell lung cancer[J]. Lancet, 2011, 378(9804): 1741-1755.
9
Nobuyuki Horita, Masaki Yamamoto, Takashi Sato, et al. Topotecan for relapsed small-cell lung cancer: systematic review and meta-analysis of 1347 patients[J]. Sci Rep, 2015, 5: 15437.
10
Spigel DR, Vicente D, Ciuleanu TE, et al. Second-line nivolumab in relapsed small-cell lung cancer: CheckMate 331(☆)[J]. Ann Oncol, 2021, 32(5): 631-641.
11
Antonia SJ, López-Martin JA, Bendell J, et al. Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial[J]. Lancet Oncol, 2016, 17(7): 883-895.
12
Chung HC, Piha-Paul SA, Lopez-Martin J, et al. Pembrolizumab after two or more lines of previous therapy in patients with recurrent or metastatic SCLC: results from the KEYNOTE-028 and KEYNOTE-158 studies[J]. J Thorac Oncol, 2020, 15(4): 618-627.
13
Yu H, Boyle TA, Zhou C, et al. PD-L1 expression in lung cancer[J]. J Thorac Oncol, 2016, 11(7): 964-975.
14
Ott PA, Elez E, Hiret S, et al. Pembrolizumab in patients with extensive-stage small-cell lung cancer: results from the phase Ib KEYNOTE-028 study[J]. J Clin Oncol, 2017, 35(34): 3823-3829.
15
Chung HC, Ros W, Delord JP, et al. Efficacy and safety of pembrolizumab in previously treated advanced cervical cancer: results from the phase Ⅱ KEYNOTE-158 study[J]. J Clin Oncol, 2019, 37(17): 1470-1478.
16
Alexandrov LB, Nik-Zainal S, Wedge DC, et al. Signatures of mutational processes in human cancer[J]. Nature, 2013, 500(7463): 415-421.
17
Horn L, Dahlberg SE, Sandler AB, et al. Phase Ⅱ study of cisplatin plus etoposide and bevacizumab for previously untreated, extensive-stage small-cell lung cancer: eastern cooperative oncology group study E3501[J]. J Clin Oncol, 2009, 27(35): 6006-6011.
18
Ready NE, Dudek AZ, Pang HH, et al. Cisplatin, irinotecan, and bevacizumab for untreated extensive-stage small-cell lung cancer: CALGB 30306, a phase Ⅱ study[J]. J Clin Oncol, 2011, 29(33): 4436-4441.
19
Tiseo M, Boni L, Ambrosio F, et al. Italian, multicenter, phase Ⅲ,randomized study of cisplatin plus etoposide with or without bevacizumab as first-line treatment in extensive-disease small-cell lung cancer: the GOIRC-AIFA FARM6PMFJM trial[J]. J Clin Oncol, 2017, 35(12): 1281-1287.
20
Cheng Y, Wang Q, Li K, et al. 1738OOverall survival (OS) update in ALTER 1202: anlotinib as third-line or further-line treatment in relapsed small-cell lung cancer (SCLC)[J]. Annal Oncol, 2019,30(Supplement_5): DOI:10.1093/annonc/mdz264.002
21
Han B, Zhang W, Zhang B, et al. P48.09 anlotinib plus etoposide and carboplatin as first-line treatment for extensive-stage small cell lung cancer: a single arm phase Ⅱ trial[J]. J Thorac Oncol, 2021, 16(3): S503.
22
Chabanon RM, Muirhead G, Krastev DB, et al. PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer[J]. J Clin Invest, 2019, 129(3): 1211-1228.
23
Jiang Y, Dai H, Li Y, et al. PARP inhibitors synergize with gemcitabine by potentiating DNA damage in non-small-cell lung cancer[J]. Int J Cancer, 2019, 144(5): 1092-1103.
24
Owen DH, Giffin MJ, Bailis JM, et al. DLL3: an emerging target in small cell lung cancer[J]. J Hematol Oncol, 2019, 12(1): 61.
25
Jiao S, Xia W, Yamaguchi H, et al. PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression[J]. Clin Cancer Res, 2017, 23(14): 3711-3720.
26
Sen T, Rodriguez BL, Chen L, et al. Targeting DNA damage response promotes antitumor immunity through STING-Mediated T-cell activation in small cell lung cancer[J]. Cancer Discov, 2019, 9(5): 646-661.
27
Dwight H Owen, Michael J Giffin, Julie M Bailis, et al. DLL3: an emerging target in small cell lung cancer[J]. J Hematol Oncol, 2019, 12(1): 61.
28
Megumi Furuta, Jun Sakakibara-Konishi, Hajime Kikuchi, et al. Analysis of DLL3 and ASCL1 in surgically resected small cell lung cancer (HOT1702)[J]. Oncologist, 2019, 24(11): e1172-e1179.
29
Rudin CM, Pietanza MC, Bauer TM, et al. Rovalpituzumabtesirine,a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study[J]. Lancet Oncol, 2017, 18(1): 42-51.
30
Morgensztern D, Besse B, Greillier L, et al. Efficacy and safety of rovalpituzumab tesirine in third-line and beyond patients with DLL3-expressing, relapsed/refractory small-cell lung cancer: results from the phase Ⅱ TRINITY study[J]. Clin Cancer Res, 2019, 25(23): 6958-6966.
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