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中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (04) : 596 -600. doi: 10.3877/cma.j.issn.1674-6902.2023.04.041

综述

循环肿瘤细胞在非小细胞肺癌中的研究进展
杜静怡, 徐兴祥()   
  1. 225001 扬州,江苏省苏北人民医院呼吸科
  • 收稿日期:2023-01-17 出版日期:2023-08-25
  • 通信作者: 徐兴祥

Research progress of circulating tumor cells in non-small cell lung cancer

Jingyi Du, Xingxiang Xu()   

  • Received:2023-01-17 Published:2023-08-25
  • Corresponding author: Xingxiang Xu
引用本文:

杜静怡, 徐兴祥. 循环肿瘤细胞在非小细胞肺癌中的研究进展[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 596-600.

Jingyi Du, Xingxiang Xu. Research progress of circulating tumor cells in non-small cell lung cancer[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(04): 596-600.

肺癌是全世界范围内癌症相关死亡最常见的原因,5年生存率只有10%~15%,大部分患者发现时已是晚期[1],其中大约85%为非小细胞肺癌(non-small cell lung cancer, NSCLC)。对于NSCLC患者而言,目前治疗手段主要包括手术、放化疗、靶向以及免疫治疗,但是并非所有患者均能从上述治疗中获益,不可避免的转移、复发及耐药大大降低了患者的总生存期(overall survival, OS)。早期诊断NSCLC,则可以更全面地评估术后转移、复发和辅助治疗的效果,并且可以降低NSCLC患者的病死率、改善其生活质量。2011年,美国国家肺癌筛查试验报告称,早期筛查可以促进早期发现、早期诊断和早期干预的发展,并且建议使用低剂量计算机断层扫描(CT)筛查肺癌,因为CT成像可使肺癌病死率降低20%[2]。但是CT存在假阳性及辐射暴露的风险,目前迫切需要具有特异性且侵入性小的生物标志物。

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