切换至 "中华医学电子期刊资源库"

中华肺部疾病杂志(电子版) ›› 2021, Vol. 14 ›› Issue (04) : 447 -449. doi: 10.3877/cma.j.issn.1674-6902.2021.04.009

临床研究

循环Tfh、肺神经源性P物质与哮喘病情程度的关系
王占彬1, 达慧娟2,(), 郝敏3   
  1. 1. 102400 北京,北京燕化医院呼吸内科
    2. 102400 北京,北京燕化医院综合内科
    3. 102400 北京,北京朝阳医院呼吸与危重症医学科
  • 收稿日期:2021-03-11 出版日期:2021-08-25
  • 通信作者: 达慧娟
  • 基金资助:
    北京市自然科学基金资助项目(2202002)

Relationship between circulating Tfh, pulmonary neurogenic substance P and the severity of asthma

Zhanbing Wang1, Huijuan Da2(), Min Hao3   

  • Received:2021-03-11 Published:2021-08-25
  • Corresponding author: Huijuan Da
引用本文:

王占彬, 达慧娟, 郝敏. 循环Tfh、肺神经源性P物质与哮喘病情程度的关系[J]. 中华肺部疾病杂志(电子版), 2021, 14(04): 447-449.

Zhanbing Wang, Huijuan Da, Min Hao. Relationship between circulating Tfh, pulmonary neurogenic substance P and the severity of asthma[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2021, 14(04): 447-449.

目的

分析循环滤泡辅助性T细胞(Tfh)、肺神经源性P物质(SP)与哮喘病情程度的关系。

方法

选取2019年1月至2021年1月医院收治的67例老年哮喘患者,根据病情严重程度分为轻度组23例,中度组25例和重度组19例,比较3组患者外周血循环Tfh、肺神经源性SP水平,比较重度患者与轻中度患者临床特征,采用Logistic回归分析法分析外周血循环Tfh、肺神经源性SP水平与老年哮喘患者病情严重程度的关系。

结果

重度和中度患者外周血循环Tfh、肺神经源性SP水平均高于轻度患者(P<0.05),且重度患者外周血循环Tfh、肺神经源性SP水平均高于中度患者(P<0.05);重度患者合并慢性阻塞性肺疾病、接触有害气体构成比与轻中度患者比较,差异均有统计学意义(P<0.05);Logistic多因素回归分析显示外周血循环Tfh、肺神经源性SP、既往接触有害气体均是老年重度哮喘的独立危险因素(OR=3.501,3.228,2.977,P<0.05)。

结论

外周血循环Tfh、肺神经源性SP水平与哮喘患者病情严重程度有关,且二者均为老年重度哮喘患者的危险因素。

表1 比较3组患者外周血循环Tfh、肺神经源性SP水平
表2 哮喘重度患者与轻中度患者临床特征
1
李 喆,莫琳芳,任成山. 支气管哮喘药物治疗现状及进展[J/CD]. 中华肺部疾病杂志(电子版), 2014, 7(5): 571-573.
2
González-Díaz SN, Villarreal-Gonzalez RV, Lira-Quezada CE, et al. Outcome measures to be considered on asthma in elderly[J]. Curr Opin Allergy Clin Immunol, 2019, 19(3): 209-215.
3
梁 巍,齐 林,胡雨薇,等. 血清CRP在支气管哮喘急性发作期的检测及临床意义[J]. 临床研究,2020, 28(1): 150-151.
4
Ravi A, Chowdhury S, Dijkhuis A, et al. Neutrophilic inflammation in asthma and defective epithelial translational control[J]. Eur Respir J, 2019, 54(2): 190-198.
5
Murrison LB, Brandt EB, Myers JB, et al. Environmental exposures and mechanisms in allergy and asthma development[J]. J Clin Invest, 2019, 129(4): 1504-1515.
6
Sharif H, Acharya S, Dhondalay GKR, et al. Altered chromatin landscape in circulating T follicular helper and regulatory cells following grass pollen subcutaneous and sublingual immunotherapy[J]. J Allergy Clin Immunol, 2021, 147(2): 663-676.
7
Fadaee J, Khoshkhui M, Emadzadeh M, et al. Evaluation of serum substance P level in chronic urticaria and correlation with disease severity[J]. Iran J Allergy Asthma Immunol, 2020, 19(1): 18-26.
8
Chen Y, Gao Y, Lu W, et al. Influence of acupuncture on the expression of VIP, SP, NKA and NKB, cAMP/cGMP and HE content and treatment of bronchial asthma in rats[J]. Cell Mol Biol (Noisy-le-grand), 2020, 66(5): 29-35.
9
严兴科. 支气管炎、哮喘[M]. 北京:中国医药科技出版社,2012: 86-88.
10
刘锦铭. 哮喘(肺部常见疾病科普丛书)[M]. 上海:同济大学出版社,2013: 115-117.
11
Zhang L, Zhang X, Zheng J, et al. Depressive symptom-associated IL-1β and TNF-α release correlates with impaired bronchodilator response and neutrophilic airway inflammation in asthma[J]. Clin Exp Allergy, 2019, 49(6): 770-780.
12
Bazan-Socha S, Kuczia P, Potaczek DP, et al. Increased blood levels of cellular fibronectin in asthma: Relation to the asthma severity, inflammation, and prothrombotic blood alterations[J]. Respir Med, 2018, 119(4): 64-71.
13
Drake MG, Scott GD, Blum ED, et al. Eosinophils increase airway sensory nerve density in mice and in human asthma[J]. Sci Transl Med, 2018, 10(457): 8477-8482.
14
Petra AI, Tsilioni I, Taracanova A, et al. Interleukin 33 and interleukin 4 regulate interleukin 31 gene expression and secretion from human laboratory of allergic diseases 2 mast cells stimulated by substance P and/or immunoglobulin E[J]. Allergy Asthma Proc, 2018, 39(2): 153-160.
15
Yao Y, Wang ZC, Yu D, et al. Role of allergen-specific T-follicular helper cells in immunotherapy[J]. Curr Opin Allergy Clin Immunol, 2018, 18(6): 495-501.
16
Kamekura R, Shigehara K, Miyajima S, et al. Alteration of circulating type 2 follicular helper T cells and regulatory B cells underlies the comorbid association of allergic rhinitis with bronchial asthma[J]. Clin Immunol, 2015, 158(2): 204-211.
17
Gong F, Zhu HY, Zhu J, et al. Circulating CXCR5+ CD4+ T cells participate in the IgE accumulation in allergic asthma[J]. Immunol Lett, 2018, 197(3): 9-14.
18
Miyajima S, Shigehara K, Kamekura R, et al. Activated circulating T follicular helper cells and skewing of T follicular helper 2 cells are down-regulated by treatment including an inhaled corticosteroid in patients with allergic asthma[J]. Allergol Int, 2020, 69(1): 66-77.
19
Sakurai S, Furuhashi K, Horiguchi R, et al. Conventional type 2 lung dendritic cells are potent inducers of follicular helper T cells in the asthmatic lung[J]. Allergol Int, 2021, 70(3): 351-359.
20
Edwards ESJ, Bosco JJ, Aui PM, et al. Predominantly antibody-deficient patients with non-infectious complications have reduced naive B, Treg, Th17, and Tfh17 Cells[J]. Front Immunol, 2019, 10(1): 2593-2598.
21
McDonald JL, Smith PK, Smith CA, et al. Effect of acupuncture on house dust mite specific IgE, substance P, and symptoms in persistent allergic rhinitis[J]. Ann Allergy Asthma Immunol, 2016, 116(6): 497-505.
22
Wang N, Wang J, Zhang Y, et al. Substance P-induced lung inflammation in mice is mast cell dependent [J]. Clin Exp Allergy, 2021, 14(6): 393-399.
23
Xu Y, Gu Q, Tang J, et al. Substance P Attenuates Hypoxia/Reoxygenation-Induced Apoptosis via the Akt Signalling Pathway and the NK1-Receptor in H9C2Cells[J]. Heart Lung Circ, 2018, 27(12): 1498-1506.
24
Li B, Han X, Ye X, et al. Substance P-regulated leukotriene B4 production promotes acute pancreatitis-associated lung injury through neutrophil reverse migration[J]. Int Immunopharmacol, 2018, 57(3): 147-156.
25
刘艳梅,何韶衡,陆思静,等. 哮喘患者嗜酸性粒细胞富集群中P物质表达上调[J]. 内蒙古大学学报(自然科学版), 2018, 49(1): 77-83.
26
徐淑琴,张晓云,薛明慧,等. 肺泡表面活性蛋白A调控Tfh亚群分化缓解哮喘气道炎症[J]. 国际免疫学杂志,2021, 44(1): 15-22.
[1] 白若靖, 郭军. 维生素D对肺部疾病临床意义的研究进展[J]. 中华肺部疾病杂志(电子版), 2024, 17(04): 659-662.
[2] 暴静, 吴霞, 田雅萍, 尹钢. 维生素D3联合孟鲁司特钠治疗支气管哮喘对血清VEGF、TGF-β1及肺功能的影响[J]. 中华肺部疾病杂志(电子版), 2024, 17(01): 63-67.
[3] 朱斯悦, 张晓莹, 严玉茹, 陈绯. 介入支气管镜在肺部疾病诊断和治疗中的应用[J]. 中华肺部疾病杂志(电子版), 2024, 17(01): 148-151.
[4] 陈华萍, 陈晓龙, 胡明冬. 难治性哮喘的发病机制及诊治进展[J]. 中华肺部疾病杂志(电子版), 2024, 17(01): 144-147.
[5] 路东明, 陈建华, 艾月琴. 布地格福吸入气雾剂治疗支气管哮喘的临床分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 361-363.
[6] 谭玲芳, 周克兵. 基于生物信息学整合鉴定与支气管哮喘相关的潜在诊断生物标志物[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 329-334.
[7] 刘汶睿, 高丽娜, 于书娴, 周建刚. 支气管哮喘患者血清IL-27与IFN-γ及肺功能相关性分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(02): 224-226.
[8] 刘娜, 赵然然. 支气管哮喘微量元素水平与免疫功能的相关性分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(01): 74-76.
[9] 李德莲, 杨鹏, 王琳. FeNO联合总IgE、CXCL13检测对儿童支气管炎继发哮喘的意义[J]. 中华肺部疾病杂志(电子版), 2022, 15(06): 838-840.
[10] 张志华, 肖晓晨, 梅少奇. 维生素D3辅助治疗哮喘合并呼吸道感染对气道重塑及免疫功能影响[J]. 中华肺部疾病杂志(电子版), 2022, 15(03): 355-357.
[11] 张超, 岳小哲. EOS、总IgE与儿童哮喘严重程度和肺功能的相关性[J]. 中华肺部疾病杂志(电子版), 2022, 15(02): 183-186.
[12] 李江华, 李力, 何勇. 呼出气一氧化氮的研究进展[J]. 中华肺部疾病杂志(电子版), 2022, 15(01): 119-122.
[13] 谢心怡, 胡宇翔, 席凡捷. 普仑司特联合丙酸氟替卡松治疗小儿哮喘的临床意义[J]. 中华肺部疾病杂志(电子版), 2022, 15(01): 100-102.
[14] 尹莉莉, 李伟, 殷爱云, 张永燕. 孟鲁司特钠联合细菌溶解产物对哮喘患儿IL-33、sST2受体、EOS、ECP的影响[J]. 中华肺部疾病杂志(电子版), 2021, 14(06): 803-805.
[15] 周泽恺, 刘宝胤, 聂云韬, 孟化. 肥胖对肺功能影响的研究进展[J]. 中华肥胖与代谢病电子杂志, 2024, 10(01): 58-65.
阅读次数
全文


摘要