切换至 "中华医学电子期刊资源库"

中华肺部疾病杂志(电子版) ›› 2023, Vol. 16 ›› Issue (06) : 845 -848. doi: 10.3877/cma.j.issn.1674-6902.2023.06.022

临床研究

单孔胸腔镜下肺段切除与肺亚段切除治疗早期非小细胞肺癌的疗效分析
李晓亮(), 樊立茂, 郭朝卫, 王新刚   
  1. 072750 河北,保定市第二中心医院胸外科
  • 收稿日期:2023-08-30 出版日期:2023-12-25
  • 通信作者: 李晓亮
  • 基金资助:
    河北省卫生健康委科研基金(20200436); 保定市科学技术项目(16ZF012)

Comparison of efficacy of single­aperture thoracoscopic segmental lung resection and subsegmental lung resection in the treatment of early non­small cell lung cancer

Xiaoliang Li(), Limao Fan, Chaowei Guo   

  • Received:2023-08-30 Published:2023-12-25
  • Corresponding author: Xiaoliang Li
引用本文:

李晓亮, 樊立茂, 郭朝卫, 王新刚. 单孔胸腔镜下肺段切除与肺亚段切除治疗早期非小细胞肺癌的疗效分析[J/OL]. 中华肺部疾病杂志(电子版), 2023, 16(06): 845-848.

Xiaoliang Li, Limao Fan, Chaowei Guo. Comparison of efficacy of single­aperture thoracoscopic segmental lung resection and subsegmental lung resection in the treatment of early non­small cell lung cancer[J/OL]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(06): 845-848.

目的

分析单孔胸腔镜下肺段切除与肺亚段切除治疗早期非小细胞肺癌(non-small cell lung cancer, NSCLC)的临床疗效。

方法

选取2019年3月至2022年3月在我院胸外科治疗的77例早期NSCLC患者为对象,根据手术术式分为观察组37例,单孔胸腔镜下肺亚段切除治疗,对照组40例,单孔胸腔镜下肺段切除治疗,对临床疗效进行分析。

结果

观察组手术时间(104.28±10.54)min、术中出血量(188.18±30.86)ml、淋巴结清扫数量(10.11±3.24)个、胸腔引流时间(3.57±0.79)d、术后卧床时间(2.06±0.38)d优于对照组(P<0.05);观察组FVC(87.88±11.44)ml、FEV1(90.33±10.96)ml、FEV1/FVC(88.54±19.74)、FEF 25%(97.77±19.04)、FEF 50%(89.76±12.38)高于对照组(P<0.05);观察组和对照组治疗后血管内皮生长因子(vascular endothelial growth factor, VEGF)、糖类抗原125(carbohydrate antigen 125, CA125)和癌胚抗原(carcinoembryonic antigen, CEA)水平无统计学意义(P>0.05);观察组治疗后生活质量评分(63.33±6.48),Karnofsky体力状况评分(80.50±5.72);对照组生活质量评分(50.66±5.12),Karnofsky体力状况评分(78.77±3.68)。两组治疗后评分比治疗前高,观察组优于对照组,差异有统计学意义(P<0.05);观察组并发症发生率8.11%,低于对照组25.00%,差异有统计学意义(P<0.05)。

结论

单孔胸腔镜下肺亚段切除治疗早期NSCLC的疗效优于肺段切除术,并发症少,患者术后生活质量高。

表1 两组患者围术期及术后恢复情况比较(±s)
表2 两组患者肺功能情况对比结果(±s)
表3 两组患者血清细胞因子水平结果比较(±s)
1
Jonna S, Subramaniam DS. Molecular diagnostics and targeted therapies in non-small cell lung cancer (NSCLC): an update[J]. Discov Med, 2019, 27(148): 167-170.
2
王洪武,金发光. 晚期非小细胞肺癌多域整合治疗策略[J/CD]. 中华肺部疾病杂志(电子版), 2022, 15(4): 457-461.
3
游雅婷,毕周奎,郭 亮,等. EGFR罕见突变非小细胞肺癌临床病理特征及疗效分析[J/CD]. 中华肺部疾病杂志(电子版), 2023, 16(5): 635-639.
4
Le X, Nilsson M, Goldman J, et al. Dual EGFR-VEGF pathway inhibition: A promising strategy for patients with EGFR-Mutant NSCLC[J]. J Thorac Oncol, 2021, 16(2): 205-215.
5
Imyanitov EN, Iyevleva AG, Levchenko EV. Molecular testing and targeted therapy for non-small cell lung cancer: Current status and perspectives[J]. Crit Rev Oncol Hematol, 2021, 157: 103194.
6
尉腊革,李 毅,张建辉,等. 单孔胸腔镜肺癌根治术后不同胸腔引流液量时拔管的康复分析[J/CD]. 中华肺部疾病杂志(电子版), 2021, 14(4): 478-480.
7
Mithoowani H, Febbraro M. Non-small-cell lung cancer in 2022: A review for general practitioners in oncology[J]. Curr Oncol, 2022, 29(3): 1828-1839.
8
Chen Z, Fillmore CM, Hammerman PS, et al. Non-small-cell lung cancers: a heterogeneous set of diseases[J]. Nat Rev Cancer, 2014, 14(8): 535-546.
9
Relli V, Trerotola M, Guerra E, et al. Abandoning the notion of non-small cell lung cancer[J]. Trends Mol Med, 2019, 25(7): 585-594.
10
Nambirajan A, Singh V, Bhardwaj N, et al. SMARCA4/BRG1-deficient non-small cell lung carcinomas: A case series and review of the literature[J]. Arch Pathol Lab Med, 2021, 145(1): 90-98.
11
高永山,张志杰,付 伟,等. 单操作孔胸腔镜肺段切除治疗早期非小细胞肺癌的学习曲线[J]. 中国微创外科杂志2021, 21(12): 1072-1076.
12
Husson O, de Rooij BH, Kieffer J, et al. The EORTC QLQ-C30 summary score as prognostic factor for survival of patients with cancer in the " Real-World" :Results from the population-based PROFILES registry[J]. Oncologist, 2020, 25(4): e722-e732.
13
Wu M, Miska J, Xiao T, et al. Race influences survival in glioblastoma patients with KPS≥80 and associates with genetic markers of retinoic acid metabolism[J]. J Neurooncol, 2019, 142(2): 375-384.
14
Liang G, Meng W, Huang X, et al. miR-196b-5p-mediated downregulation of TSPAN12 and GATA6 promotes tumor progression in non-small cell lung cancer[J]. Proc Natl Acad Sci U S A, 2020, 117(8): 4347-4357.
15
Herbst RS, Morgensztern D, Boshoff C. The biology and management of non-small cell lung cancer[J]. Nature, 2018, 553(7689): 446-454.
16
Russo A, Franchina T, Ricciardi GRR, et al. Third generation EGFR TKIs in EGFR-mutated NSCLC: Where are we now and where are we going[J]. Crit Rev Oncol Hematol, 2017, 117: 38-47.
17
Selvaggi G, Scagliotti GV. Histologic subtype in NSCLC: does it matter?[J]. Oncology (Williston Park), 2009, 23(13): 1133-1140.
18
Landre T, Justeau G, Assié JB, et al. Anti-PD-(L)1 for KRAS-mutant advanced non-small-cell lung cancers: A Meta-analysis of randomized-controlled trials[J]. Cancer Immunol Immunother, 2022, 1(3): 719-726.
19
De Ruysscher D, Dingemans AM, Vooijs M, et al. PD-(L)1 inhibition and cardiac damage: A relevant toxicity?[J]. J Thorac Oncol, 2018, 13(4): 478-479.
20
Myers CJ, Lu B. Decreased Survival After Combining Thoracic Irradiation and an Anti-PD-1 Antibody Correlated With Increased T-cell Infiltration Into Cardiac and Lung Tissues[J]. Int J Radiat Oncol Biol Phys, 2017, 99(5): 1129-1136.
21
Kim S, Kim MY, Koh J, et al. Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas[J]. Eur J Cancer, 2015, 51(17): 2698-2707.
22
Xu P, Zhang P, Sun Z, et al. Surgical trauma induces postoperative T-cell dysfunction in lung cancer patients through the programmed death-1 pathway[J]. Cancer Immunol Immunother, 2015, 64(11): 1383-1392.
23
Apte RS, Chen DS, Ferrara N. VEGF in signaling and disease: Beyond discovery and development[J]. Cell, 2019, 176(6): 1248-1264.
24
Zhao Y, Adjei AA.Targeting angiogenesis in cancer therapy: Moving beyond vascular endothelial growth factor[J]. Oncologist, 2015, 20(6): 660-673.
25
Zhang C, Wang N, Tan HY, et al. Targeting VEGF/VEGFRs pathway in the antiangiogenic treatment of human cancers by traditional Chinese Medicine[J]. Integr Cancer Ther, 2018, 17(3): 582-601.
[1] 杨慧, 郭丽娟, 冯晓丹, 李静, 黄成谋, 蔡兴锐, 覃英娇, 王远礼. 非小细胞肺癌铂类药物耐药mi RNA表达特征及预测分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 719-724.
[2] 赖淼, 景鑫, 李桂珍, 李怡. 非小细胞肺癌EGFR 突变亚型的临床病理和预后意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 731-737.
[3] 梁丽斯, 李洁, 贺帅, 来艳君, 刘铭, 张琳. MMP-9、MMP-2 及TLR4、HE4对非小细胞肺癌早期诊断意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 756-761.
[4] 张礼江, 沈玲佳, 施我大. 倾向性评分匹配分析奥希替尼对晚期NSCLC 预后的影响[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 820-822.
[5] 赵蒙蒙, 黄洁, 余荣环, 王葆青. 过表达小GTP酶Rab32抑制非小细胞肺癌细胞侵袭性生长[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 512-518.
[6] 张桂萍, 丘勇林, 湛绮婷, 孙乐栋. 晚期非小细胞肺癌血清Ape1/Ref-1对放射性肺损伤发生的预测意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 519-523.
[7] 韩晓宇, 李柯育, 赵志菲, 高建平. SNHG17过表达对非小细胞肺癌切除术预后的意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 543-547.
[8] 刘松, 张进召, 贾艳云. 帕博利珠单抗治疗晚期非小细胞肺癌反应降低与抗生素预处理的关系[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 553-557.
[9] 李多, 郝昭昭, 陈延伟, 南岩东. 血清PTX3表达与非小细胞肺癌骨转移的相关性分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 558-562.
[10] 陈旭, 牛凯, 孙建国. 放疗联合免疫治疗对驱动基因阴性NSCLC的困惑分析及应对策略[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(03): 341-348.
[11] 杨静, 附舰, 康艳霞. 血浆ctDNA T790M突变和总代谢肿瘤体积对晚期EGFR突变NSCLC患者TKIs治疗及预后意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(03): 379-384.
[12] 崔伟, 邓屹, 叶苏意, 李静, 陈晓明, 张靖, 许荣德. 载药微球支气管动脉化疗栓塞术治疗罕见非小细胞肺癌的临床疗效和安全性分析[J/OL]. 中华介入放射学电子杂志, 2024, 12(04): 303-310.
[13] 崔伟, 叶苏意, 邓屹, 陈晓明, 张靖, 李静, 许荣德. 载药微球支气管动脉化疗栓塞术治疗难治性非小细胞肺癌的临床疗效及安全性[J/OL]. 中华介入放射学电子杂志, 2024, 12(04): 311-316.
[14] 崔伟, 李静, 陈晓明, 张靖, 邓屹, 许荣德. 载药微球支气管动脉化疗栓塞术治疗非小细胞肺癌的研究进展[J/OL]. 中华介入放射学电子杂志, 2024, 12(04): 289-295.
[15] 蔡剑桥, 蒋雷. 单孔胸腔镜与开胸双袖式肺叶切除治疗非小细胞肺癌对比[J/OL]. 中华胸部外科电子杂志, 2024, 11(04): 225-230.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?