目的

分析非小细胞肺癌（non-small cell lung cancer，NSCLC）患者认知水平与癌因性疲乏的相关性，提高NSCLC 患者生存质量。

方法

选择2021 年1 月至2023 年12 月空军军医大学第一附属医院收治的75 例NSCLC 患者为对象，采用临床资料调查表、简易精神状态检查表（mini-mental status examination，MMSE）、Piper 疲乏修订量表（revised Piper fatigue scale，RPFS），调查NSCLC 患者MMSE 评分、RPFS 评分，分析NSCLC 患者认知水平与癌因性疲乏状况，采用Pearson 相关性分析NSCLC 患者认知水平定向力、即刻记忆、注意力和计算力、回忆能力、语言能力、总分评分与癌因性疲乏行为维度、情感维度、感觉维度、认知维度、疲乏得分的相关性。

结果

NSCLC 患者认知水平总分为（24.68±4.17）分，平均（0.85±0.12）分。 75 例患者癌因性疲乏发生率100%，RPFS 评分行为维度（10.68±2.17）分、情感维度（12.44±2.12）分、感觉维度（15.31±2.88）分、认知维度（15.44±3.52）分，总疲乏（53.78±8.45）分。 Pearson相关性分析显示，NSCLC 患者认知水平每维度，包括定向力、即刻记忆、注意力和计算力、回忆能力、语言能力、总评分与癌因性疲乏行为维度、情感维度、认知维度、总疲乏评分呈负相关（P＜0.001）。 75 例NSCLC 患者出院后6 个月死亡6 例（8.00%），其中死亡原因为肺部感染4 例（66.67%）、呼吸衰竭1 例（16.67%）、脑转移1 例（16.67%）。

结论

NSCLC 患者认知水平与癌因性疲乏密切相关，提高NSCLC 患者认知水平，对改善癌因性疲乏具有临床意义。

Objective

To analyze the correlation between cognitive level and cancer-related fatigue in patients with non-small cell lung cancer （NSCLC），and to improve the quality of life in patients with NSCLC.

Methods

All of 75 patients with NSCLC admitted to the First Affiliated Hospital of Air Force Medical University from January 2021 to December 2023 were selected as subjects. Clinical data questionnaire and minimental status examination （MMSE）and revised Piper fatigue scale （RPFS） were used to investigate MMSE score and RPFS score of NSCLC patients，and to analyze the cognitive level and cancer-related fatigue status of NSCLC patients. Pearson correlation was used to analyze the correlation between the cognitive scores of NSCLC patients in each dimension （orientation，immediate memory，attention and computation，recall ability，language ability and total score） and the behavioral dimension，emotional dimension，sensory dimension，cognitive dimension and fatigue score of cancer-related fatigue.

Results

The total score of NSCLC patients' cognitive level was （24.68±4.17），and the average score was （0.85±0.12）. The incidence of cancer-related fatigue in 75 patients was 100%，and RPFS score was behavioral dimension （10.68±2.17） ，emotional dimension（12.44±2.12），ensory dimension（15.31±2.88），cognitive dimension，（15.44±3.52） and total fatigue（53.78±8.45）. Pearson correlation analysis showed that the cognitive scores of NSCLC patients in each dimension（orientation，immediate memory，attention and computation，recall ability，language ability，total score） were negatively correlated with the behavioral dimension，emotional dimension，cognitive dimension，and total fatigue score （P＜0.001）. In the 75 patients with NSCLC，6 cases（8%） died in 6 months after discharge，among which the causes of death were pulmonary infection in 4 cases （66.62%），respiratory failure in 1 case（16.67%） and brain metastasis in 1 case （16.67%）.

Conclusion

The cognitive level of NSCLC patients is closely related to cancer-related fatigue，and improving the cognitive level of NSCLC patients has clinical significance in alleviating cancer-related fatigue.